专利检索 ap:("Centre National de la Recherche Scientifique (CNRS)" OR "Institut Gustave-Roussy" OR "Institut National de la Santé et de la Recherche Médicale (INSERM)" OR "Institut Curie" OR "Université Paris Cité") AND inv:"HERMINE, Olivier" 第 1 页

1.

发明公开
NOVEL SEROTONIN ANALOGUES AND THEIR USES FOR TREATING IRON-ASSOCIATED DISORDERS 审中-公开

公开(公告)号：EP4137131A1

公开(公告)日：2023-02-22

申请号：EP21306124.5

申请日：2021-08-17

申请人： Centre National de la Recherche Scientifique (CNRS) , Institut Gustave-Roussy , Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut Curie , Université Paris Cité

发明人： RODRIGUEZ, Raphaël , COTE, Francine , COMAN, Tereza , DEBIEU, Sylvain , CANEQUE COBO, Tatiana , HERMINE, Olivier , MULLER, Sebastian , FALABREGUE, Marion

IPC分类号： A61K31/4045 , A61P7/06 , C07D209/00

摘要： The present invention relates to novel serotonin analogues of formula (I):

or a pharmaceutically acceptable salt and/or solvate thereof.
Another object of the present invention relates to the use of compound of formula (I) as a drug, in particular in the prevention and/or the treatment of iron overload- associated disorders.

2.

发明公开
USE OF THE EMM ANTIGEN AS A BIOMARKER OF INHERITED GPI DEFICIENCIES 审中-公开

公开(公告)号：EP4259828A1

公开(公告)日：2023-10-18

申请号：EP21820634.0

申请日：2021-12-08

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Assistance Publique Hôpitaux de Paris , Centre National de la Recherche Scientifique (CNRS) , Fondation Imagine , Université Paris Cité , Université Antilles Guyane , Etablissement Français Du Sang (EFS)

发明人： PEYRARD, Thierry , AZOUZI, Slim , HERMINE, Olivier , COLIN-ARONOVICZ, Yves , DUVAL, Romain , LE VAN KIM, Caroline

IPC分类号： C12Q1/6883 , G01N33/80

3.

发明公开
NOVEL SEROTONIN DERIVATIVES AND THEIR USES FOR TREATING IRON-ASSOCIATED DISORDERS 审中-实审

公开(公告)号：EP4387614A1

公开(公告)日：2024-06-26

申请号：EP22764804.5

申请日：2022-08-17

申请人： Centre National de la Recherche Scientifique (CNRS) , Institut Gustave Roussy , INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Curie , Université Paris Cité

发明人： RODRIGUEZ, Raphaël , COTE, Francine , COMAN, Tereza , DEBIEU, Sylvain , CANEQUE COBO, Tatiana , HERMINE, Olivier , MULLER, Sebastian , FALABRÈGUE, Marion

IPC分类号： A61K31/4045 , A61P7/06 , C07D209/16

CPC分类号： A61K31/4045 , A61P7/06 , C07D209/16

4.

发明公开
UTILISATION D'HYDROXYCARBAMIDE POUR PREVENIR LA NON-PERFUSION RETINIENNE 审中-公开

公开(公告)号：EP3331517A1

公开(公告)日：2018-06-13

申请号：EP16750804.3

申请日：2016-08-08

申请人： Centre Hospitalier National d'Ophtalmologie Quinze-Vingts , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Imagine Institut des Maladies Génétiques Necker Enfants Malades , Assistance Publique - Hôpitaux de Paris , Université Paris Descartes

发明人： COLIN, Yves , GIRMENS, Jean-François , HERMINE, Olivier , HERON, Emmanuel , PAQUES, Michel

IPC分类号： A61K31/17 , A61P27/02

摘要： The present invention relates to the use of hydroxycarbamide (HC) for reducing and/or delaying the extension of capillary nonperfusion, a cause of irreparable visual impairment in patients suffering from central retinal vein occlusion (CRVO). This is the first systemic treatment which makes it possible to reduce retinal ischemic complications in patients in whom (CRVO) has been recently diagnosed and is consequently in a rapidly progressive phase. Given the low toxicity of HC evaluated on a large scale in children and adults in the context of other diseases for decades, the results of the present study open up a new therapeutic approach in the treatment of CRVO.

5.

发明公开
METHODS FOR DETERMINING THE RISK OF ACUTE GRAFT VERSUS HOST DISEASE 审中-公开
标题翻译：方法用于确定急性移植物抗宿主病的危险

公开(公告)号：EP2923208A1

公开(公告)日：2015-09-30

申请号：EP13792933.7

申请日：2013-11-21

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Assistance Publique Hôpitaux De Paris , Université Paris Descartes , Imagine Institut des Maladies Génétiques Necker Enfants Malades

发明人： HERMINE, Olivier , RUBIO, Marie Thérèse , BOUILLIE, Marie , LEITE DE MORAES, Maria

IPC分类号： G01N33/68 , G01N33/50 , G01N33/569

CPC分类号： G01N33/505 , G01N33/56972 , G01N33/6893 , G01N2333/55 , G01N2333/7051 , G01N2333/70514 , G01N2800/245 , G01N2800/50 , G01N2800/52

摘要： The present invention relates to a method for determining whether a candidate human transplant donor is at risk of inducing acute graft versus host disease (aGVHD) in a human transplant recipient, which may in turn allow the selection of a donor exhibiting no risk for the recipient. The present invention also relates to a method for adjusting the immunosuppressive treatment administered to a human transplanted recipient following its graft transplantation after having performing the method for determining risk of the invention. The methods comprise expanding the candidate donor's iNKT cells (invariant NKT cells) and determining the presence or absence of expansion of the CD4(−) iNKT cell sub-population. In particular, CD3+CD4− TCRV[alpha]24V[beta]11 cells are determined. Kits are disclosed.