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公开(公告)号：EP3026113B1
公开(公告)日：2018-05-02
申请号：EP15199741.8
申请日：2009-09-18
申请人： Codexis, Inc.
发明人： COLBECK, Jeffrey , MIJTS, Benjamin , GIVER, Lorraine Joan , FOX, Richard, J. , MITCHELL, Vesna , PAK, Bumshik, Robert , GILSON, Lynne
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
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2.发明公开COMBINED AUTOMATED PARALLEL SYNTHESIS OF POLYNUCLEOTIDE VARIANTS 有权KOMBINIERTE自动同步并联合成VON POLYNUKLEOTIDVARIANTEN
公开(公告)号：EP3026113A2
公开(公告)日：2016-06-01
申请号：EP15199741.8
申请日：2009-09-18
申请人： Codexis, Inc.
发明人： COLBECK, Jeffrey , MIJTS, Benjamin , GIVER, Lorraine Joan , FOX, Richard, J. , MITCHELL, Vesna , PAK, Bumshik, Robert , GILSON, Lynne
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
摘要翻译： 本公开内容涉及用于有效合成，克隆，转化和筛选多核苷酸变体的大型不同文库的方法，其包含相对于参照多核苷酸的明确的核苷酸差异。
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公开(公告)号：EP3026113A3
公开(公告)日：2016-07-27
申请号：EP15199741.8
申请日：2009-09-18
申请人： Codexis, Inc.
发明人： COLBECK, Jeffrey , MIJTS, Benjamin , GIVER, Lorraine Joan , FOX, Richard, J. , MITCHELL, Vesna , PAK, Bumshik, Robert , GILSON, Lynne
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for efficient synthesis, cloning, transformation and screening of large diverse libraries of polynucleotide variants comprising well-defined nucleotide differences relative to a reference polynucleotide.
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公开(公告)号：EP2451951A1
公开(公告)日：2012-05-16
申请号：EP09845944.9
申请日：2009-09-18
申请人： Codexis, Inc.
发明人： COLBECK, Jeffrey , MIJTS, Benjamin , GIVER, Lorraine Joan , FOX, Richard, J. , MITCHELL, Vesna , PAK, Bumshik, Robert , GILSON, Lynne
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
摘要： The present disclosure relates to methods for generating libraries of polynucleotide variants comprising defined nucleotide differences relative to a reference polynucleotide.
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公开(公告)号：EP2451951B1
公开(公告)日：2016-04-13
申请号：EP09845944.9
申请日：2009-09-18
申请人： Codexis, Inc.
发明人： COLBECK, Jeffrey , MIJTS, Benjamin , GIVER, Lorraine Joan , FOX, Richard, J. , MITCHELL, Vesna , PAK, Bumshik, Robert , GILSON, Lynne
CPC分类号： C12N15/102 , C12N15/1093 , C40B40/06 , C40B50/06
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6.发明授权
公开(公告)号：EP2483292B1
公开(公告)日：2014-11-12
申请号：EP10821065.9
申请日：2010-09-24
申请人： Codexis, Inc.
发明人： GILSON, Lynne , COLLIER, Steven James , SUKUMARAN, Joly , YEO, Wan Lin , ALVISO, Oscar , TEO, Ee Ling , WILSON, Robert John , XU, Junye
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶。
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公开(公告)号：EP2483292A1
公开(公告)日：2012-08-08
申请号：EP10821065.9
申请日：2010-09-24
申请人： Codexis, Inc.
发明人： GILSON, Lynne , COLLIER, Steven James , SUKUMARAN, Joly , YEO, Wan Lin , ALVISO, Oscar , TEO, Ee Ling , WILSON, Robert John , XU, Junye
IPC分类号： C07K14/00
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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