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    A Medical Device Coating Having an Anti-thrombotic Conjugate
    4.
    发明公开
    A Medical Device Coating Having an Anti-thrombotic Conjugate 有权
    Verfahren zur Herstellung von anti-thrombotischen Konjugat Partikeln。

    公开(公告)号：EP2269666A2

    公开(公告)日：2011-01-05

    申请号：EP10187104.4

    申请日：2008-04-12

    申请人： Cordis Corporation

    发明人： Zhao, Jonathon

    IPC分类号： A61L31/10 ,  A61L31/16 ,  A61L33/08

    CPC分类号： A61F2/0077 ,  A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L33/08 ,  A61L2300/42 ,  C09D133/14 ,  C08L67/04 ,  C08L29/04 ,  C08L5/10

    摘要： A method of making a plurality of particles utilizing a polymer anti-thrombotic conjugated material as a carrier for a therapeutic agent, comprises:
    dissolving a therapeutic agent and a polymeric anti-thrombotic conjugate in at least one solvent to form a first solution,
    mixing the first solution with a second aqueous solution comprising water and at least a surfactant to form an emulsion, and
    removing the solvent from the emulsion to form a plurality of particles.

    摘要翻译： 使用聚合物抗血栓形成共轭材料作为治疗剂的载体制备多个颗粒的方法包括：将治疗剂和聚合物抗血栓形成缀合物溶解在至少一种溶剂中以形成第一溶液，将 第一溶液，其中包含水和至少一种表面活性剂的第二水溶液形成乳液，并从乳液中除去溶剂以形成多个颗粒。

    Adhesion promoting temporary mask for coated surfaces
    5.
    发明公开
    Adhesion promoting temporary mask for coated surfaces 有权
    Die HaftungförderndevorübergehendeAbdeckungfürbeschichteteOberflächen

    公开(公告)号：EP2201915A1

    公开(公告)日：2010-06-30

    申请号：EP09177243.4

    申请日：2009-11-26

    申请人： Cordis Corporation

    发明人： Dave, Vipul ,  Falotico, Robert ,  Li, Chengxue ,  Nguyen, Thai M ,  Parker, Theodore L ,  Zhao, Jonathon

    IPC分类号： A61F2/90 ,  A61L31/00

    CPC分类号： A61F2/91 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/16 ,  A61L33/0011 ,  A61L2300/00

    摘要： A method of making an intraluminal medical device (10)(1206) having a plurality of openings (30) therein involves applying a mask (1202) to interior surfaces (1204) of a scaffold which has openings formed in it. A coating (1208) which includes an anti-thrombotic material is applied to the surfaces of the scaffold. The mask and any coating adhered to the mask are removed from the interior surfaces of the plurality of openings in the intraluminal scaffold. The openings are filled at least partially with one or more therapeutic agents (1210).

    摘要翻译： 制造其中具有多个开口（30）的管腔内医疗装置（10）（1206）的方法包括向其中形成有开口的支架的内表面（1204）施加掩模（1202）。 将包含抗血栓形成材料的涂层（1208）施加到支架的表面。 掩模和附着在掩模上的任何涂层从管腔内支架中的多个开口的内表面移除。 至少部分地用一种或多种治疗剂填充开口（1210）。

    Organic radiographic contrasting agents for medical devices
    7.
    发明公开
    Organic radiographic contrasting agents for medical devices 有权
    有机的X射线造影剂的医疗器械

    公开(公告)号：EP1795209A3

    公开(公告)日：2008-01-23

    申请号：EP06256221.0

    申请日：2006-12-06

    申请人： Cordis Corporation

    发明人： Zhao, Jonathon

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0442 ,  A61K49/0433 ,  A61K49/0447

    摘要： The present invention discloses an organic radiographic contrasting agent containing an aliphatic or alicyclic backbone and multiple halogen-substituted aromatic groups. Each of the halogen-substituted aromatic groups in the radiographic contrasting agent is substituted with at least three halogen atoms and is covalently attached to the aliphatic or alicyclic backbone. The present invention also discloses a radio-opaque polymeric material comprising the radiographic contrasting agent and at least one polymer. The radiographic contrasting agent is physically admixed with the at least one polymer or physically embedded or dispersed in the at least one polymer. The radio-opaque polymeric material provides enhanced contrasting intensity in radiographic imaging. The radio-opaque polymeric material can be applied on at least a portion of one surface of a medical device. The radio-opaque polymeric material can also be used to construct a medical device, a component thereof, or a portion of a component thereof.

    Method of fabricating biodegradable medical devices with enhanced mechanical strength and pharmacological functions
    10.
    发明公开
    Method of fabricating biodegradable medical devices with enhanced mechanical strength and pharmacological functions 审中-公开
    具有改进的机械强度和药理作用的可生物降解的医疗设备

    公开(公告)号：EP2363156A3

    公开(公告)日：2012-04-04

    申请号：EP11162789.9

    申请日：2006-02-10

    申请人： Cordis Corporation

    发明人： Zhao, Jonathon

    IPC分类号： A61L31/10 ,  A61L31/08 ,  A61K31/06 ,  A61K31/02 ,  A61L31/12 ,  A61K31/12

    CPC分类号： A61K31/02 ,  A61K31/06 ,  A61K31/12 ,  A61L31/08 ,  A61L31/10 ,  A61L31/124 ,  A61L31/128 ,  A61L2420/04 ,  C08L67/04

    摘要： The present invention is directed to a medical device, specifically a prosthesis which utilizes a novel class of blends between biodegradable polymers and bioceramics for medical device applications allowing one to capitalize on the biodegradable nature of these two distinct materials while enhancing the strength of these devices through the addition of various amounts of bioactive ceramic and glasses to biodegradable polymers. The blend may be fabricated into a medical device such as a stent or a distal protection device, and may incorporate various agents to enhance radioapacity and/or pharmacological function. In addition, the blend may be used as a coating to a medical device.
    In one embodiment a method to fabricate a stent or distal protection device comprises the steps of:
    blending a biodegradable polymer solution with bioactive ceramic particles to create a material; and either
    forming said material into a desired shape for a stent or a distal protection device application; or
    applying said material as a coating material to encapsulate a stent or distal protection device.