公开(公告)号：EP1827492B1

公开(公告)日：2010-08-11

申请号：EP05852645.0

申请日：2005-11-30

申请人： Curagen Corporation ,  Abgenix, Inc.

发明人： RASTELLI, Luca ,  POLLACK, Vincent, A. ,  TSE, Kam, Fai ,  KLAKAMP, Scott ,  FOORD, Orit ,  LIANG, Meina ,  JIA, Xiao-Chi ,  XIAO, Feng ,  LICHENSTEN, Henri ,  HERRMANN, John ,  LAROCHELLE, William, J. ,  JEFFERS, Michael, E. ,  CHAPOVAL, Andrei ,  MEZES, Peter ,  ARA, Gulshan ,  TORGOV, Michael ,  KARKARIA, Cyrus ,  DAVAGNINO, Juan

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  G01N33/574 ,  G01N33/577

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human lonoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. the present invention futher provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.

公开(公告)号：EP1827492A2

公开(公告)日：2007-09-05

申请号：EP05852645.0

申请日：2005-11-30

申请人： Curagen Corporation ,  Abgenix, Inc.

发明人： RASTELLI, Luca ,  POLLACK, Vincent, A. ,  TSE, Kam, Fai ,  KLAKAMP, Scott ,  FOORD, Orit ,  LIANG, Meina ,  JIA, Xiao-Chi ,  XIAO, Feng ,  LICHENSTEN, Henri ,  HERRMANN, John ,  LAROCHELLE, William, J. ,  JEFFERS, Michael, E. ,  CHAPOVAL, Andrei ,  MEZES, Peter ,  ARA, Gulshan ,  TORGOV, Michael ,  KARKARIA, Cyrus ,  DAVAGNINO, Juan

IPC分类号： A61K39/395 ,  A61K47/48 ,  A61P35/00 ,  C07K16/30 ,  C07K19/00 ,  C12N1/21 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  G01N33/574 ,  G01N33/577

CPC分类号： C07K16/3053 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/62 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/94

摘要： The present invention provides fully human lonoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. the present invention futher provides bispecific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.

公开(公告)号：EP1370659A2

公开(公告)日：2003-12-17

申请号：EP02761846.1

申请日：2002-01-16

申请人： Curagen Corporation

发明人： PADIGARU, Muralidhara ,  ALSOBROOK, John, P., II ,  COLMAN, Steven, D. ,  SPYTEK, Kimberly, A. ,  BOLDOG, Ferenc ,  VERNET, Corine, A., M. ,  LI,Li ,  SHENOY, Suresh ,  CASMAN, Stacie ,  GUO, Xiaojia ,  EDINGER, Shlomit ,  MACDOUGALL, John ,  MALYANKAR, Uriel, M. ,  PATTURAJAN, Meera ,  SHIMKETS, Richard, A. ,  PENA, Carol ,  TCHERNEV, Velizar ,  ZERHUSEN, Bryan, D. ,  MILLET, Isabelle ,  MILLER, Charles, E. ,  LEPLEY, Denise, M. ,  SMITHSON, Glennda ,  BAUMGARTNER, Jason ,  HERRMANN, John ,  PEYMAN, John, A. ,  GORMAN, Linda ,  MEZES, Peter ,  MEZES, Peter ,  TAUPIER, Raymond, J., Jr. ,  GERLACH, Valerie ,  GROSSE, William, M. ,  LIU, Xiaohong ,  ELLERMAN, Karen ,  ROTHENBERG, Mark ,  STONE, David, J. ,  BURGESS, Catherine, E. ,  KEKUDA, Ramesh

IPC分类号： C12N15/12 ,  C12N5/10 ,  C12N1/21 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/50

摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.