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公开(公告)号：EP1149066A4
公开(公告)日：2002-09-04
申请号：EP00911725
申请日：2000-02-04
申请人： EMISPHERE TECH INC
IPC分类号： A61K9/00 , A61K9/20 , A61K47/18 , C07C231/00 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/58 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68 , C07C229/14
CPC分类号： A61K9/0014 , A61K9/0031 , A61K9/2013 , A61K47/18 , A61K47/183 , C07C231/00 , C07C233/51 , C07C235/24 , C07C235/34 , C07C235/64 , C07C235/74 , C07C271/28 , C07C271/54 , C07C271/58 , C07C275/42 , C07C309/59 , C07C317/44 , C07D239/91 , C07D239/94 , C07D239/96 , C07D265/26 , C07D311/18 , C07D317/68 , C07C235/58
摘要： The present invention relates to a method of preparing an alkylated salicylamide from a protected and activated salicylamide (hereinafter referred to as a 'protected/activated salicylamide'). The method comprises the steps of (a) alkylating the protected/activated salicylamide with an alkylating agent to form a protected/activated alkylated salicylamide, and (b) deprotecting and deactivating the protected/activated alkylated salicylamide, simultaneously or in any order, to form the alkylated salicylamide. The alkylated salicylamides prepared by this method are suitable for use in compositions for delivering active agents via oral or other routes of administration to animals.
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公开(公告)号：EP2057112A4
公开(公告)日：2010-07-14
申请号：EP07841534
申请日：2007-08-29
发明人： LIAO JUN , TANG PINGWAH , GSCHNEIDNER DAVID , MAEYER JONATHAN
IPC分类号： C07C63/00
CPC分类号： A61K31/192 , A61K9/0019 , A61K9/0095 , A61K31/00 , A61K38/27 , A61K38/28 , A61K47/12 , C07C59/68 , C07C59/90 , A61K2300/00
摘要： The present invention provides delivery agent compounds, compositions containing delivery agent compounds and an active agent and methods for delivering active agents, such as biologically or chemically active agents.
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公开(公告)号：EP1756039A4
公开(公告)日：2007-05-02
申请号：EP05752138
申请日：2005-05-16
申请人： EMISPHERE TECH INC
发明人： GOMEZ-ORELLANA MARIA ISABEL , GSCHNEIDNER DAVID , LEONE-BAY ANDREA , MOYE-SHERMAN DESTARDI , PUSZTAY STEPHEN V , RATH PARSHURAM , TANG PINGWAH , WEIDNER JOHN J , SONG JIANFENG
IPC分类号： C07C229/00 , A01N37/44 , A61K31/195 , A61K45/06 , C07C233/07
CPC分类号： C07C233/07 , A61K9/0031 , A61K9/0073 , A61K9/0095 , A61K9/2013 , A61K31/192 , A61K31/195 , A61K38/00 , A61K45/06 , A61K47/183 , C07C2601/14 , A61K2300/00
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4.发明公开(5-(2-HYDROXY-4-CHLOROBENZOYL) AMINOVALERIC ACID AND SALTS THEREOF AND COMPOSITIONS CONTAINING THE SAME FOR DELIVERING ACTIVE AGENTS 有权（5-（2-羟基-4-氯苯甲酰基）VALERIA丙烯酸和它们的盐，以及组合物用于供给物质，这些化合物
公开(公告)号：EP1322595A4
公开(公告)日：2005-03-23
申请号：EP01977774
申请日：2001-09-05
申请人： EMISPHERE TECH INC
发明人： GSCHNEIDNER DAVID
IPC分类号： A61K9/00 , A61K31/195 , A61K31/20 , A61K31/715 , A61K47/18 , C07C235/60 , C07C229/08 , C09K3/00
CPC分类号： A61K9/0095 , A61K9/0053 , A61K31/195 , A61K31/20 , A61K31/715 , A61K47/183 , C07C235/60
摘要： (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid, salts thereof, and compositions containing the same for the delivery of active agents are provided. Methods of administration, treatment of disease and preparation are provided as well.
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公开(公告)号：EP1100522A4
公开(公告)日：2003-01-08
申请号：EP99938806
申请日：1999-07-27
申请人： EMISPHERE TECH INC
发明人： MILSTEIN SAM J , SMART JOHN E , SARUBBI DONALD J , CAROZZA MONICA , FLANDERS ELIZABETH , O'TOOLE DORIS , LEONE-BAY ANDREA , GSCHNEIDNER DAVID
IPC分类号： A61K9/08 , A61K9/00 , A61K9/14 , A61K9/20 , A61K9/48 , A61K9/72 , A61K31/16 , A61K31/70 , A61K31/726 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/12 , A61K38/17 , A61K38/18 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/24 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61K38/43 , A61K39/395 , A61K45/00 , A61K45/08 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/42 , A61P3/10 , A61P5/00 , C07C235/64
CPC分类号： C07C235/64 , A61K9/0073 , A61K9/0095 , A61K31/16 , A61K31/727 , A61K38/00 , A61K38/1709 , A61K38/1816 , A61K38/27 , A61K38/28 , A61K38/29 , A61K38/30 , A61K47/183 , Y02P20/582
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公开(公告)号：EP1156787A4
公开(公告)日：2002-04-24
申请号：EP00913480
申请日：2000-02-11
申请人： EMISPHERE TECH INC
发明人： GSCHNEIDNER DAVID
IPC分类号： A61K31/353 , A61K31/70 , A61K31/715 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/23 , A61K38/27 , A61K38/28 , A61K38/55 , A61K45/00 , A61K45/06 , A61K47/22 , A61P5/22 , C07D271/10 , A61K9/20 , A61K9/48 , A61K31/415
CPC分类号： C07D271/10 , A61K31/727 , A61K38/23 , A61K38/27 , A61K38/29 , A61K45/06 , A61K47/22
摘要： Oxadiazole compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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公开(公告)号：EP1015008A4
公开(公告)日：2006-08-09
申请号：EP98905042
申请日：1998-02-06
申请人： EMISPHERE TECH INC
发明人： LEONE-BAY ANDREA , HO KOC-KAN , LEIPOLD HARRY R , MILSTEIN SAM J , SARRUBI DONALD J , WANG ERIC , GSCHNEIDNER DAVID
IPC分类号： A61K38/23 , A61K47/16 , A61K9/08 , A61K9/16 , A61K9/20 , A61K9/48 , A61K31/16 , A61K31/195 , A61K31/352 , A61K31/70 , A61K31/7052 , A61K31/726 , A61K31/727 , A61K38/00 , A61K38/04 , A61K38/11 , A61K38/21 , A61K38/22 , A61K38/27 , A61K38/28 , A61K38/29 , A61K39/00 , A61K39/395 , A61K45/00 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61P5/00 , A61P43/00 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D209/48 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/18 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30
CPC分类号： A61K31/727 , A61K9/1617 , A61K38/21 , A61K38/27 , A61K38/29 , A61K47/183 , C07C229/42 , C07C233/51 , C07C233/54 , C07C233/69 , C07C233/81 , C07C233/83 , C07C235/12 , C07C235/24 , C07C235/34 , C07C235/38 , C07C235/52 , C07C235/56 , C07C235/60 , C07C235/64 , C07C235/66 , C07C235/74 , C07C237/12 , C07C237/20 , C07C237/36 , C07C237/40 , C07C237/42 , C07C243/38 , C07C259/06 , C07C271/28 , C07C271/54 , C07D209/48 , C07D211/62 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/24 , C07D257/04 , C07D295/192 , C07D311/12 , C07D311/24 , C07D311/30
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公开(公告)号：EP1237872A4
公开(公告)日：2005-06-15
申请号：EP00986516
申请日：2000-12-18
申请人： EMISPHERE TECH INC
发明人： GSCHNEIDNER DAVID , LEONE-BAY ANDREA , WANG ERIC , FREEMAN JOHN J JR , O'TOOLE DORIS , SHIELDS LYNN E
IPC分类号： A61K47/16 , A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , C07C235/60 , C07C235/64 , C07C235/84 , C07C237/42 , C07D229/00 , A61K38/17 , A61K38/29
CPC分类号： C07C235/60 , C07C235/64 , C07C235/84 , C07C237/42
摘要： Amino acid derivative as carrier compounds and compositions which are useful in the delivery of active agents are provided. The active agents can be a peptide, mucopolysaccharide, carbohydrate, or lipid. Methods of administration, including oral administration, and preparation are provided as well.
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9.发明公开PHENOXY CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS 有权PHENOXYCARBONSÄUREVERBINDUNGEN和给药的组合物的活性物质
公开(公告)号：EP1226104A4
公开(公告)日：2005-05-04
申请号：EP00979142
申请日：2000-11-06
申请人： EMISPHERE TECH INC
发明人： LEONE-BAY ANDREA , KRAFT KELLY , MOYE-SHERMAN DESTARDI , GSCHNEIDNER DAVID , BOYD MARIA A P , LIU PUCHUN , TANG PINGWAH , LIAO JUN , SMART JOHN E , FREEMAN JOHN J JR
IPC分类号： A61K9/08 , A61K9/14 , A61K9/20 , A61K9/48 , A61K31/352 , A61K31/727 , A61K38/00 , A61K38/21 , A61K38/23 , A61K38/27 , A61K38/28 , A61K45/00 , A61K47/12 , A61K47/18 , A61P3/10 , A61P5/10 , A61P5/14 , A61P5/48 , A61P7/02 , A61P19/08 , A61P19/10 , A61P31/04 , A61P37/08 , A61P43/00 , C07C59/66 , C07C59/68 , C07C59/90 , C07C59/92 , C07C65/21 , C07C65/24 , C07C65/40 , C07C205/37 , C07C217/84 , C07C229/18 , C07C229/56 , C07C233/25 , C07C235/46 , C07C235/48 , C07C237/30 , C07C62/32
CPC分类号： C07C65/24 , C07C59/68 , C07C59/90 , C07C59/92 , C07C65/40 , C07C229/18 , C07C229/56 , C07C237/30
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公开(公告)号：EP2114145A4
公开(公告)日：2013-11-06
申请号：EP08782758
申请日：2008-02-08
申请人： EMISPHERE TECH INC
IPC分类号： A01N31/00 , A01N37/30 , A61K9/00 , A61K9/20 , A61K31/205 , A61K38/26 , A61K38/28 , A61K47/12
CPC分类号： A61K47/12 , A61K9/0095 , A61K9/2013 , A61K38/26 , A61K38/28 , A61K45/06
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