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    Compounds useful in treating sickle cell anemia
    7.
    发明公开
    Compounds useful in treating sickle cell anemia 失效
    Verbindungen von Nutzen bei der Behandlung vom Herrickschen Syndrom。

    公开(公告)号：EP0240256A2

    公开(公告)日：1987-10-07

    申请号：EP87302643.9

    申请日：1987-03-26

    申请人： Merck & Co., Inc. ,  UNIVERSITY OF PITTSBURGH

    发明人： Abraham, Donald J. ,  Cragoe, Edward J., Jr. ,  Woltersdorf, Otto W., Jr.

    IPC分类号： C07C59/90 ,  C07C62/38 ,  C07C233/46 ,  C07C235/32 ,  C07C235/70 ,  C07C205/27 ,  C07C205/49

    CPC分类号： C07C205/54 ,  C07C45/46 ,  C07C49/835 ,  C07C59/74 ,  C07C59/90 ,  C07C59/92 ,  C07C65/30 ,  C07C205/32 ,  C07C205/33 ,  C07C49/825

    摘要： The present invention is directea to compounds or the formula (I) useful as anti-sickling agents and to pharmaceutical compositions of these compounds wherein formula


    V is selected from:

    which R, is ethyl, propyl or isopropyl;

    in which R 2 is H or lower alkyl;
    in which
    R 3 is lower alkyl;

    W is selected from:


    . A 2 is (CH 2 )n 2 -C(CH 3 ) 2 , -C(CH 2 ) 3 - and n 2 = 1 to 5; X is 0 or 1;

    R3 is HO- or

    A3 is -(CH 2 )n 3 or -C(CH 2 ) 3 - and
    n 3 = 1 to 5;
    m is 0 or 1;
    and
    Y is H, Cl or OCH 3 ;
    Z is H or Cl;
    provided that

    (i) when W is
    and Y and Z are Cl;
    (ii) when W is
    Y and Z are Cl, with the proviso that when R 2 is C 2 H 5 , R 2 is H and X is O, n 2 is 2 to 5;
    (iii) When W is
    with the proviso that when R3 is OH, Y is H or Cl and m is 1, n 3 = 4 or 5; (iv) when W is
    and Y and Z are Cl.

    摘要翻译： 本发明涉及可用作抗镰刀剂的式（I）化合物和这些化合物的药物组合物，其中式（I）： V选自CHEM，其中R 1是乙基，丙基或 异丙基; 其中R2为H或低级烷基的CHEM; 其中R 3为低级烷基; （d） - @ -CH = CH 2; W选自：（a）其中A 1是（CH 2）n1，-C（CH 2）3和n1 = 2,4或5的HO-@ -Al-O- 其中R 2为H，低级烷基，苄基，CH 2 OH; H