公开(公告)号：EP0790228A1

公开(公告)日：1997-08-20

申请号：EP95935597.5

申请日：1995-10-31

申请人： Eisai Co., Ltd.

发明人： HIBI, Shigeki ,  KIKUCHI, Kouichi ,  YOSHIMURA, Hiroyuki ,  NAGAI, Mitsuo ,  TAGAMI, Katsuya ,  ABE, Shinya ,  HISHINUMA, Ieharu ,  NAGAKAWA, Junichi ,  MIYAMOTO, Norimasa ,  HIDA, Takayuki ,  OGASAWARA, Aichi ,  HIGASHI, Seiko ,  TAI, Kenji ,  YAMANAKA, Takashi ,  ASADA, Makoto

IPC分类号： C07C53/00 ,  C07C229/00 ,  C07D209/08 ,  C07D215/14 ,  C07D223/16 ,  C07D265/36 ,  C07D471/06 ,  C07D487/04 ,  C07D495/04 ,  C07D521/00

CPC分类号： C07D213/69 ,  C07C57/03 ,  C07C229/44 ,  C07D209/08 ,  C07D215/12 ,  C07D215/14 ,  C07D215/18 ,  C07D223/16 ,  C07D225/06 ,  C07D231/12 ,  C07D233/16 ,  C07D241/38 ,  C07D241/42 ,  C07D241/46 ,  C07D261/18 ,  C07D263/32 ,  C07D265/36 ,  C07D333/76 ,  C07D405/14 ,  C07D455/04 ,  C07D487/04 ,  C07D495/04 ,  G06F17/30607 ,  Y02P20/55

摘要： To provide novel compounds relating to retinoid which can substitute for retinoic acid used for preventing and treating several diseases and having antagonism against retinoid.
Heterocyclic compounds represented by the general formula (1-I) or physiologically acceptable salts thereof:

        Z-(CR 3 =CR 2 ) n -COOR 1      (1-I)


Compounds represented by the general formula (2-I) or physiologically acceptable salts thereof:

The compounds according to the present invention exhibit extremely high ability to bind RARs and are effective for treating various kind of diseases such as abnormality in cornification and rheumatoid arthritis.

摘要翻译： 提供与维甲酸相关的新化合物，其可以代替用于预防和治疗几种疾病并对类视黄醇具有拮抗作用的视黄酸。 由通式（1-I）表示的杂环化合物或其生理学上可接受的盐：Z-（CR 3 = CR 2）n -COOR 1由通式（2-I）表示的化合物或生理学上 其可接受的盐：本发明的化合物显示出极高的结合RAR的能力，并且对于治疗各种类型的疾病如角质化和类风湿性关节炎的异常是有效的。

公开(公告)号：EP0877020A1

公开(公告)日：1998-11-11

申请号：EP95932954.1

申请日：1995-10-02

申请人： Eisai Co., Ltd.

发明人： MIYAMOTO, Mitsuaki ,  YOSHIUCHI, Tatsuya ,  ABE, Shinya ,  TANAKA, Masayuki ,  MORIYA, Katsuhiro ,  KATAYAMA, Satoshi ,  YAMANAKA, Takashi ,  YAMADA, Koji

IPC分类号： C07D219/06 ,  C07D401/06 ,  C07D405/06 ,  C07D409/06 ,  A61K31/435 ,  A61K31/495 ,  A61K31/535 ,  A61K31/445 ,  A61K31/44

CPC分类号： C07D219/14

摘要： An acridone derivative represented by the following formula (I) and a pharmacologically acceptable salt thereof are effective in preventing and curing diseases which are associable with histamine, leucotriene, etc. and in preventing and curing allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, urticaria, valerian fever, digestive tract allergy, or food allergy.
wherein R 1 - R 8 severally represent a hydrogen atom, a lower alkyl group, etc. and n represents an integer of 1 - 6.