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公开(公告)号：EP1507530B1
公开(公告)日：2005-11-02
申请号：EP03752731.4
申请日：2003-05-12
发明人： CHU, Xin-Jie , DING, Qingjie , JIANG, Nan , KIM, Kyungjin , LOVEY, Allen, John , McCOMAS, Warren, William , MULLIN, John, Guilfoyle, Jr. , TILLEY, Jefferson, Wright
IPC分类号： A61K31/426 , A61K31/427 , C07D277/42 , C07D417/06 , C07D417/12 , A61P35/00
CPC分类号： C07D417/06 , C07D277/42 , C07D417/12 , C07D417/14
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公开(公告)号：EP1237878A2
公开(公告)日：2002-09-11
申请号：EP00989906.3
申请日：2000-11-28
IPC分类号： C07D239/06 , A61K31/505 , A61P1/04 , A61P19/02
CPC分类号： C07D239/54 , A61K38/00 , C07K5/06165
摘要： Coumpounds of Formula (I) are disclosed, wherein R1 to R6 are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
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3.发明公开
公开(公告)号：EP1171452A2
公开(公告)日：2002-01-16
申请号：EP00929365.5
申请日：2000-04-17
IPC分类号： C07K5/02 , C07C323/60 , A61K38/04
CPC分类号： C07C323/60 , A61K38/00 , C07C2601/08 , C07C2603/18 , C07K5/0202 , C07K5/0205 , C07K5/0207
摘要： Compounds of formula (I) are described which have activity as anti-inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
摘要翻译： 描述了具有作为抗炎剂活性的式（I）化合物。 提供了抑制细胞与内皮结合的环状二硫化物化合物。 此类化合物可用于治疗其症状和/或损伤与细胞粘附分子与整联蛋白表达细胞的结合有关的炎性疾病如哮喘。
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公开(公告)号：EP1005445A1
公开(公告)日：2000-06-07
申请号：EP98945235.4
申请日：1998-08-13
发明人： CHEN, Li , GUTHRIE, Robert, William , HUANG, Tai-Nang , HULL, Kenneth, G. , SIDDURI, Achytharao , TILLEY, Jefferson, Wright
IPC分类号： C07C233/87 , C07C235/52 , C07C237/36 , C07C317/50 , C07C323/39 , C07D215/50 , C07D233/32 , C07D295/088 , C07D487/04 , A61K31/165 , A61K31/33
CPC分类号： C07D213/82 , C07C233/87 , C07C235/52 , C07C237/36 , C07C311/17 , C07C311/21 , C07C317/44 , C07C323/62 , C07D211/64 , C07D215/30 , C07D215/50 , C07D233/32 , C07D233/36 , C07D239/28 , C07D249/06 , C07D261/18 , C07D277/56 , C07D295/15 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： Compounds of formula (1) as well as their salts and esters are disclosed wherein X, X', Z and Y are as described in the specification and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
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公开(公告)号：EP1237878B1
公开(公告)日：2007-03-21
申请号：EP00989906.3
申请日：2000-11-28
IPC分类号： C07D239/06 , A61K31/505 , A61P1/04 , A61P19/02
CPC分类号： C07D239/54 , A61K38/00 , C07K5/06165
摘要： Coumpounds of Formula (I) are disclosed, wherein R1 to R6 are as defined in specification and which are inhibitors of binding between VCAM-1 and cells expressing VLA-4, and accordingly are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
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6.发明授权PYRROLIDINCARBOLYLAMINO CYCLIC DISULFIDES AS VCAM-VLA4 ANTAGONISTS 有权吡咯烷酮亚胺基环糊精包封抗体拮抗剂VAN VCAM-VLA4
公开(公告)号：EP1171452B1
公开(公告)日：2006-08-23
申请号：EP00929365.5
申请日：2000-04-17
IPC分类号： C07K5/02 , C07C323/60 , A61K38/04
CPC分类号： C07C323/60 , A61K38/00 , C07C2601/08 , C07C2603/18 , C07K5/0202 , C07K5/0205 , C07K5/0207
摘要： Compounds of formula (I) are described which have activity as anti-inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
摘要翻译： 描述了具有作为抗炎剂的活性的式的化合物。 提供了环状二硫化物化合物，其抑制细胞与内皮的结合。 这些化合物可用于治疗诸如哮喘的炎性疾病，其症状和/或损伤与细胞粘附分子与整联蛋白表达细胞的结合有关。
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公开(公告)号：EP1244625B1
公开(公告)日：2005-06-15
申请号：EP00985117.1
申请日：2000-11-29
IPC分类号： C07D213/64 , A61P29/00
CPC分类号： C07D213/64
摘要： Compounds of Formula (I) are disclosed wherein R1-R7 are as defined in the application and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4 and, therefore, are useful for treating diseases whose symptoms and or damage are related to the binding of VCAM-1 to cells expressing VLA-4, such as chronic inflammatory diseases.
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公开(公告)号：EP2274297B1
公开(公告)日：2012-05-09
申请号：EP09732665.6
申请日：2009-04-06
发明人： BERTHEL, Steven, Joseph , BRINKMAN, John, A. , HAYDEN, Stuart , HAYNES, Nancy-Ellen , KESTER, Robert, Francis , McDERMOTT, Lee, Apostle , QIAN, Yimin , SARABU, Ramakanth , SCOTT, Nathan, Robert , TILLEY, Jefferson, Wright
IPC分类号： C07D401/12 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/12 , C07F7/18 , A61K31/41 , A61K31/4155 , A61K31/427 , A61K31/44 , A61K31/497 , A61P3/10
CPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要： Provided herein are compounds of the formula (I): wherein X, R
1 , R
2 and R
3 are as defined in the specification, as well as pharmaceutically acceptable salts thereof. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.-
公开(公告)号：EP1663936A1
公开(公告)日：2006-06-07
申请号：EP04737037.4
申请日：2004-06-18
IPC分类号： C07C65/05 , C07D307/68 , C07D333/40 , C07D213/79 , C07D277/56 , C07D405/06 , A61P5/48
CPC分类号： C07D213/79 , C07C65/24 , C07D277/56 , C07D307/68 , C07D333/40 , C07D405/06
摘要： The present invention relates to compounds of formula (1) wherein R1, R2 , R3 , R4 , m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof and to pharmaceutical compositions thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
摘要翻译： 本发明涉及其中R 1，R 2，R 3，R 4，m，n，p和s如说明书和权利要求书中所定义的式（1）化合物及其药学上可接受的盐和其药物组合物。 该化合物可用于治疗和/或预防与糖原合成酶如糖尿病的活化有关的疾病。
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公开(公告)号：EP1154993B1
公开(公告)日：2004-10-06
申请号：EP00903680.7
申请日：2000-02-10
IPC分类号： C07C327/46 , C07C327/48 , C07D401/06 , C07D213/82 , C07D231/08 , A61K31/44 , A61K31/167 , A61P29/00
CPC分类号： C07D213/82 , C07C327/46 , C07C327/48 , C07C2601/04 , C07C2601/08 , C07D213/56 , C07D233/38 , C07D239/28 , C07D401/06
摘要： Compounds of formula (1): and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), asthma, and inflammatory bowel disease (I/BD).
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