公开(公告)号：EP1778251A2

公开(公告)日：2007-05-02

申请号：EP05857701.6

申请日：2005-07-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  LIN, Kuei-Ying ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PETRAKOVSKY, Oleg, V. ,  RAY, Adrian, S. ,  ZHANG, Lijun

IPC分类号： A61K31/662 ,  C07F9/38 ,  A61K47/48

CPC分类号： C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1628685B1

公开(公告)日：2010-12-08

申请号：EP04750807.2

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  JIN, Haolun ,  HIRSCHMANN, Ralph, F. ,  HUANG, Alan, X. ,  KIM, Choung, U. ,  KIRSCHBERG, Thorsten, A. ,  LEE, Christopher, P. ,  LEE, William, A. ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PRASAD, Vidya, K. ,  PYUN, Hyung-Jung ,  RAY, Adrian, S. ,  SHERLOCK, Rosemarie ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Jennifer, R. ,  OARE, David

IPC分类号： A61K47/48 ,  C07F9/02 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H21/00

CPC分类号： C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1628685A2

公开(公告)日：2006-03-01

申请号：EP04750807.2

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  JIN, Haolun ,  HIRSCHMANN, Ralph, F. ,  HUANG, Alan, X. ,  KIM, Choung, U. ,  KIRSCHBERG, Thorsten, A. ,  LEE, Christopher, P. ,  LEE, William, A. ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PRASAD, Vidya, K. ,  PYUN, Hyung-Jung ,  RAY, Adrian, S. ,  SHERLOCK, Rosemarie ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Jennifer, R. ,  OARE, David

IPC分类号： A61K47/48 ,  C07F9/02 ,  C07F9/6561

CPC分类号： C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1778251B1

公开(公告)日：2011-04-13

申请号：EP05857701.6

申请日：2005-07-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  LIN, Kuei-Ying ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PETRAKOVSKY, Oleg, V. ,  RAY, Adrian, S. ,  ZHANG, Lijun

IPC分类号： A61K31/662 ,  A61K31/7076 ,  A61P31/18 ,  A61K47/48 ,  C07H19/16

CPC分类号： C07H19/16 ,  A61K31/341 ,  A61K31/513 ,  A61K31/662 ,  A61K31/675 ,  A61K31/683 ,  A61K45/06 ,  C07F9/65616 ,  C07H19/00 ,  C07H19/20 ,  A61K2300/00

摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的抗病毒抑制化合物，含有这些化合物的组合物和包括施用这些化合物的治疗方法以及可用于制备这些化合物的方法和中间体。

公开(公告)号：EP1617848A2

公开(公告)日：2006-01-25

申请号：EP04750828.8

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC. ,  Boojamra, Constantine G. ,  Cannizzaro, Carina E. ,  Chen, James M. ,  Chen, Xiaowu ,  Cho, Aesop

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  HUANG, Alan, X. ,  KIM, Choung, X. ,  KIRSCHBERG, Thorsten, A. ,  KRAWCZYK, Steven ,  LEE, Christopher, P. ,  LIN, Kuei-Ying ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  NELSON, Peter H. ,  OARE, David ,  PRASAD, Vidya K. ,  PYUN, Hyung-Jung ,  RAY, Adrian S. ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Lijun ,  ZHANG, Jennifer

IPC分类号： A61K31/662

CPC分类号： A61K31/662 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D239/94 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07D487/04 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561

摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.