-
公开(公告)号：EP1617848A2
公开(公告)日：2006-01-25
申请号：EP04750828.8
申请日：2004-04-26
申请人： GILEAD SCIENCES, INC. , Boojamra, Constantine G. , Cannizzaro, Carina E. , Chen, James M. , Chen, Xiaowu , Cho, Aesop
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , HUANG, Alan, X. , KIM, Choung, X. , KIRSCHBERG, Thorsten, A. , KRAWCZYK, Steven , LEE, Christopher, P. , LIN, Kuei-Ying , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , NELSON, Peter H. , OARE, David , PRASAD, Vidya K. , PYUN, Hyung-Jung , RAY, Adrian S. , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Lijun , ZHANG, Jennifer
IPC分类号： A61K31/662
CPC分类号： A61K31/662 , A61K47/548 , C07D205/04 , C07D211/58 , C07D239/94 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07D487/04 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
-
公开(公告)号：EP2726460B1
公开(公告)日：2015-09-23
申请号：EP12735394.4
申请日：2012-06-29
发明人： CANNIZZARO, Carina, E. , GRAUPE, Michael , GUERRERO, Juan, A. , LU, Yafan , STRICKLEY, Robert, G. , VENKATARAMANI, Chandrasekar , ZABLOCKI, Jeff
IPC分类号： C07D213/64 , A61K31/4418 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/581 , C07F9/584
-
公开(公告)号：EP2943493B1
公开(公告)日：2017-08-02
申请号：EP14701647.1
申请日：2014-01-09
发明人： BONDY, Steven, S. , CANNIZZARO, Carina, E. , CHOU, Chien-Hung , HU, Yunfeng, Eric , LINK, John, O. , LIU, Qi , SCHROEDER, Scott, D. , TSE, Winston, C. , ZHANG, Jennifer, R.
IPC分类号： C07D487/04 , C07D513/04 , A61P31/18
CPC分类号： C07D513/04 , C07D471/14 , C07D487/04
-
公开(公告)号：EP2943487A1
公开(公告)日：2015-11-18
申请号：EP14705605.5
申请日：2014-01-09
发明人： BONDY, Steven, S. , CANNIZZARO, Carina, E. , CHOU, Chien-Hung , LINK, John, O. , LIU, Qui , SCHROEDER, Scott, D. , TSE, Winston, C. , ZHANG, Jennifer, R.
IPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/437 , A61K31/422 , A61K31/427 , A61K31/4245 , A61K31/4192 , A61K31/4196 , A61K31/4178 , A61K31/4162 , A61K31/416 , A61P31/00
CPC分类号： A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/437 , A61K45/06 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Compounds of formula I: or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
-
公开(公告)号：EP2726460A1
公开(公告)日：2014-05-07
申请号：EP12735394.4
申请日：2012-06-29
发明人： CANNIZZARO, Carina, E. , GRAUPE, Michael , GUERRERO, Juan, A. , LU, Yafan , STRICKLEY, Robert, G. , VENKATARAMANI, Chandrasekar , ZABLOCKI, Jeff
IPC分类号： C07D213/64 , A61K31/4418 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/581 , C07F9/584
摘要： Disclosed are novel compounds having the structure of Formula (I) : which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
-
6.发明公开N-[4-(2-OXO-1,2-DIHYDRO-PYRIDIN-4-YL)-BENZYL]-BENZAMIDE DERIVATIVES AS ALDH-2 INHIBITORS FOR THE TREATMENT OF ADDICTION 有权N- [4-（2-氧代-1,2-二氢 - 吡啶-4-基） - 苯基] - 苯甲酸衍生物ALS ALDH-2抑制剂ZUR SUCHTBEHANDLUNG
公开(公告)号：EP2993170A1
公开(公告)日：2016-03-09
申请号：EP15184883.5
申请日：2012-06-29
发明人： CANNIZZARO, Carina, E. , GRAUPE, Michael , GUERRERO, Juan, A. , LU, Yafan , STICKLEY, Robert, G. , VENKATARAMANI, Chandrasekar , ZABLOCKI, Jeff
IPC分类号： C07D213/64 , A61K31/4418 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/581 , C07F9/584
摘要： Disclosed are N-[4-(2-oxo-1,2-dihydro-pyridin-4-yl)-benzyl]-benzamide derivatives which are useful as human mitochondrial aldehyde dehydrogenase (ALDH-2) inhibitors for treating chemical dependency on dopamine-producing agents such as cocaine, opiates, amphetamines, nicotine and alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of said compounds and methods of using the compounds in the treatment of addiction.
摘要翻译： 公开了用作治疗对多巴胺的化学依赖性的人线粒体醛脱氢酶（ALDH-2）抑制剂的N- [4-（2-氧代-1,2-二氢 - 吡啶-4-基） - 苄基] - 苯甲酰胺衍生物 生产剂如可卡因，阿片剂，安非他明，尼古丁和酒精。 还公开了包含治疗有效量的所述化合物的药物组合物和使用该化合物治疗成瘾的方法。
-
公开(公告)号：EP1628685B1
公开(公告)日：2010-12-08
申请号：EP04750807.2
申请日：2004-04-26
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , JIN, Haolun , HIRSCHMANN, Ralph, F. , HUANG, Alan, X. , KIM, Choung, U. , KIRSCHBERG, Thorsten, A. , LEE, Christopher, P. , LEE, William, A. , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , PRASAD, Vidya, K. , PYUN, Hyung-Jung , RAY, Adrian, S. , SHERLOCK, Rosemarie , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Jennifer, R. , OARE, David
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
-
公开(公告)号：EP1628685A2
公开(公告)日：2006-03-01
申请号：EP04750807.2
申请日：2004-04-26
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , JIN, Haolun , HIRSCHMANN, Ralph, F. , HUANG, Alan, X. , KIM, Choung, U. , KIRSCHBERG, Thorsten, A. , LEE, Christopher, P. , LEE, William, A. , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , PRASAD, Vidya, K. , PYUN, Hyung-Jung , RAY, Adrian, S. , SHERLOCK, Rosemarie , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Jennifer, R. , OARE, David
IPC分类号： A61K47/48 , C07F9/02 , C07F9/6561
CPC分类号： C07F9/65616 , A61K31/662 , A61K31/7072 , A61K31/7076 , A61K47/548 , C07D205/04 , C07D211/58 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561 , C07H15/00 , C07H17/00 , C07H19/056 , C07H19/10 , C07H19/20 , C07H21/00 , Y02A50/393 , Y02A50/465
摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
-
公开(公告)号：EP2069303A2
公开(公告)日：2009-06-17
申请号：EP07810622.6
申请日：2007-07-19
发明人： CANNIZZARO, Carina, E. , YANG, Zheng-Yu , DESAI, Manoj, C. , MITCHELL, Michael, L. , XU, Lianhong , SWAMINATHAN, Sundaramoorthi , CHEN, James, M.
IPC分类号： C07D213/56 , C07D401/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and /or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
-
公开(公告)号：EP2049547A2
公开(公告)日：2009-04-22
申请号：EP07836151.6
申请日：2007-07-19
发明人： CANNIZZARO, Carina, E. , CHEN, James, M. , DESAI, Manoj, C. , MITCHELL, Michael, L. , SWAMINATHAN, Sundaramoorthi , XU, Lianhong
IPC分类号： C07D493/04 , C07D519/00 , C07D405/12 , A61K31/443 , A61K31/34 , A61P31/18
CPC分类号： C07D493/04 , C07D405/12 , C07D519/00
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and /or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.047 秒)
