公开(公告)号：EP1617848A2

公开(公告)日：2006-01-25

申请号：EP04750828.8

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC. ,  Boojamra, Constantine G. ,  Cannizzaro, Carina E. ,  Chen, James M. ,  Chen, Xiaowu ,  Cho, Aesop

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  HUANG, Alan, X. ,  KIM, Choung, X. ,  KIRSCHBERG, Thorsten, A. ,  KRAWCZYK, Steven ,  LEE, Christopher, P. ,  LIN, Kuei-Ying ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  NELSON, Peter H. ,  OARE, David ,  PRASAD, Vidya K. ,  PYUN, Hyung-Jung ,  RAY, Adrian S. ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Lijun ,  ZHANG, Jennifer

IPC分类号： A61K31/662

CPC分类号： A61K31/662 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D239/94 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07D487/04 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561

摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1628685B1

公开(公告)日：2010-12-08

申请号：EP04750807.2

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  JIN, Haolun ,  HIRSCHMANN, Ralph, F. ,  HUANG, Alan, X. ,  KIM, Choung, U. ,  KIRSCHBERG, Thorsten, A. ,  LEE, Christopher, P. ,  LEE, William, A. ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PRASAD, Vidya, K. ,  PYUN, Hyung-Jung ,  RAY, Adrian, S. ,  SHERLOCK, Rosemarie ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Jennifer, R. ,  OARE, David

IPC分类号： A61K47/48 ,  C07F9/02 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H21/00

CPC分类号： C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1628685A2

公开(公告)日：2006-03-01

申请号：EP04750807.2

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC.

发明人： BOOJAMRA, Constantine, G. ,  CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  JIN, Haolun ,  HIRSCHMANN, Ralph, F. ,  HUANG, Alan, X. ,  KIM, Choung, U. ,  KIRSCHBERG, Thorsten, A. ,  LEE, Christopher, P. ,  LEE, William, A. ,  MACKMAN, Richard, L. ,  MARKEVITCH, David, Y. ,  PRASAD, Vidya, K. ,  PYUN, Hyung-Jung ,  RAY, Adrian, S. ,  SHERLOCK, Rosemarie ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Jennifer, R. ,  OARE, David

IPC分类号： A61K47/48 ,  C07F9/02 ,  C07F9/6561

CPC分类号： C07F9/65616 ,  A61K31/662 ,  A61K31/7072 ,  A61K31/7076 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07H15/00 ,  C07H17/00 ,  C07H19/056 ,  C07H19/10 ,  C07H19/20 ,  C07H21/00 ,  Y02A50/393 ,  Y02A50/465

摘要： The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

公开(公告)号：EP1663254A2

公开(公告)日：2006-06-07

申请号：EP04750871.8

申请日：2004-04-26

申请人： GILEAD SCIENCES, INC.

发明人： CANNIZZARO, Carina, E. ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CHO, Aesop ,  CHONG, Lee, S. ,  FARDIS, Maria ,  GIBBS, Craig ,  HIRSCHMANN, Ralph, F. ,  KIRSCHBERG, Thorsten, A. ,  LEE, Christopher, P. ,  LIN, Kuei-Ying ,  MACKMAN, Richard, L. ,  NELSON, Peter, H. ,  OARE, David ,  PYUN, Hyung-Jung ,  RAY, Adrian, S. ,  SHERLOCK, Rosemarie ,  SWAMINATHAN, Sundaramoorthi ,  WATKINS, Will ,  ZHANG, Jennifer R. ,  MILLER, Gerard, D.

IPC分类号： A61K31/662

CPC分类号： A61K31/662 ,  A61K47/548 ,  C07D205/04 ,  C07D211/58 ,  C07D409/06 ,  C07D409/14 ,  C07D413/14 ,  C07D475/00 ,  C07D487/04 ,  C07F9/4075 ,  C07F9/5728 ,  C07F9/582 ,  C07F9/588 ,  C07F9/60 ,  C07F9/65037 ,  C07F9/650941 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/65515 ,  C07F9/655354 ,  C07F9/6561 ,  C07F9/65616

摘要： The invention is related to phosphorus substituted anti-inflammatory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

摘要翻译： 本发明涉及磷取代的抗炎化合物，含有这些化合物的组合物，以及包括给予这些化合物的治疗方法，以及可用于制备这些化合物的方法和中间体。