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公开(公告)号：EP1617848A2
公开(公告)日：2006-01-25
申请号：EP04750828.8
申请日：2004-04-26
申请人： GILEAD SCIENCES, INC. , Boojamra, Constantine G. , Cannizzaro, Carina E. , Chen, James M. , Chen, Xiaowu , Cho, Aesop
发明人： BOOJAMRA, Constantine, G. , CANNIZZARO, Carina, E. , CHEN, James, M. , CHEN, Xiaowu , CHO, Aesop , CHONG, Lee, S. , FARDIS, Maria , HUANG, Alan, X. , KIM, Choung, X. , KIRSCHBERG, Thorsten, A. , KRAWCZYK, Steven , LEE, Christopher, P. , LIN, Kuei-Ying , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , NELSON, Peter H. , OARE, David , PRASAD, Vidya K. , PYUN, Hyung-Jung , RAY, Adrian S. , SWAMINATHAN, Sundaramoorthi , WATKINS, Will , ZHANG, Lijun , ZHANG, Jennifer
IPC分类号： A61K31/662
CPC分类号： A61K31/662 , A61K47/548 , C07D205/04 , C07D211/58 , C07D239/94 , C07D409/06 , C07D409/14 , C07D413/14 , C07D475/00 , C07D487/04 , C07F9/4075 , C07F9/5728 , C07F9/582 , C07F9/588 , C07F9/60 , C07F9/65037 , C07F9/650941 , C07F9/653 , C07F9/6539 , C07F9/65515 , C07F9/655354 , C07F9/6561
摘要： The invention is related to phosphorus substituted anti-cancer compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP2576534A1
公开(公告)日：2013-04-10
申请号：EP11725838.4
申请日：2011-05-26
发明人： CHO, Aesop , KIM, Choung, U. , RAY, Adrian, S. , ZHANG, Lijun
IPC分类号： C07D309/10 , A61K31/40 , A61P31/14
CPC分类号： C07F9/6561 , A61K31/40 , C07D309/10 , C07F9/00
摘要： Provided are prodrugs of pyrrolo[l,2-f][l,2,4]triazin-7-yl nucleoside phosphates wherein the 1 ' position of the nucleoside sugar is substituted with CN. The compounds, compositions, and methods provided are useful for the treatment Hepatitis C infections.
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3.发明公开NUCLEOSIDE PHOSPHONATE CONJUGATES AS ANTI HIV AGENTS 有权由2'-氟-2”，3'-二脱氢-2' 模拟膦酸酯的前药，3'-抗HIV剂DIDEOXYADENOSINS ALS
公开(公告)号：EP1778249A2
公开(公告)日：2007-05-02
申请号：EP05777315.2
申请日：2005-07-27
发明人： BOOJAMRA, Constantine G. , LIN, Kuei-Ying , MACKMAN, Richard L. , MARKEVITCH, David Y. , PETRAKOVSKY, Oleg V. , RAY, Adrian, S. , ZHANG, Lijun
IPC分类号： A61K31/662
CPC分类号： C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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公开(公告)号：EP2576534B1
公开(公告)日：2014-03-19
申请号：EP11725838.4
申请日：2011-05-26
发明人： CHO, Aesop , KIM, Choung, U. , RAY, Adrian, S. , ZHANG, Lijun
IPC分类号： C07D309/10 , A61K31/40 , A61P31/14
CPC分类号： C07F9/6561 , A61K31/40 , C07D309/10 , C07F9/00
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5.发明公开PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS 有权过程和中间产物1'-取代的碳代核苷类似物的制造
公开(公告)号：EP2480559A1
公开(公告)日：2012-08-01
申请号：EP10757699.3
申请日：2010-09-20
发明人： BUTLER, Thomas , CHO, Aesop , GRAETZ, Benjamin, R. , KIM, Choung, U. , METOBO, Samuel, E. , SAUNDERS, Oliver, L. , WALTMAN, Andrew, W. , XU, Jie , ZHANG, Lijun
CPC分类号： C07H1/00 , A61K31/7052 , A61K31/7056 , A61K31/706 , C07H19/23
摘要： Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,24][1,2,4]triazinyl heterocycles of Formula I.
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6.发明授权CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权HIV蛋白酶抑制剂化合物及其化合物的膦酸盐类似物的细胞积累
公开(公告)号：EP1509537B9
公开(公告)日：2007-11-14
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, W. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A. , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
摘要翻译： 公开了具有用作治疗剂和用于其他工业目的的HIV蛋白酶抑制性质的膦酸酯取代的化合物。 该组合物抑制HIV蛋白酶活性和/或可用于治疗AIDS和其他抗病毒感染以及用于检测HIV蛋白酶的分析。
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公开(公告)号：EP1778251A2
公开(公告)日：2007-05-02
申请号：EP05857701.6
申请日：2005-07-26
发明人： BOOJAMRA, Constantine, G. , LIN, Kuei-Ying , MACKMAN, Richard, L. , MARKEVITCH, David, Y. , PETRAKOVSKY, Oleg, V. , RAY, Adrian, S. , ZHANG, Lijun
IPC分类号： A61K31/662 , C07F9/38 , A61K47/48
CPC分类号： C07H19/16 , A61K31/341 , A61K31/513 , A61K31/662 , A61K31/675 , A61K31/683 , A61K45/06 , C07F9/65616 , C07H19/00 , C07H19/20 , A61K2300/00
摘要： The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.
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8.发明公开CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH 有权富集在单元格中膦酸酯类似物的HIV蛋白酶抑制剂化合物和接线SELF
公开(公告)号：EP1509537A2
公开(公告)日：2005-03-02
申请号：EP03747326.1
申请日：2003-04-25
发明人： ARIMILLI, Murty, N. , BECKER, Mark, M. , BRYANT, Clifford , CHEN, James, M. , CHEN, Xiaowu , DASTGAH, Azar , FARDIS, Maria , HE, Gong-Xin , JIN, Haolun , KIM, Choung, U. , LEE, William, A. , LEE, Christopher, P. , LIN, Kuei-Ying , LIU, Hongtao , MACKMAN, Richard, L. , MITCHELL, Michael, L. , NELSON, Peter, H. , PYUN, Hyung-Jung , ROWE, Tanisha, D. , SWAMINATHAN, Sundaramoorthi , TARIO, James, D. , ZHANG, Lijun , SPARACINO, Mark , WANG, Jianying , WILLIAMS, Matthew, A , XU, Lianhong , YANG, Zheng-Yu , YU, Richard, H. , ZHANG, Jiancun
CPC分类号： A61K31/66 , A61K31/675 , C07D213/75 , C07D213/85 , C07D231/12 , C07D231/20 , C07D233/42 , C07D239/49 , C07D239/80 , C07D243/04 , C07D265/18 , C07D307/68 , C07D401/06 , C07D403/06 , C07D471/14 , C07D491/04 , C07F9/4006 , C07F9/582 , C07F9/588 , C07F9/645 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/650911 , C07F9/650917 , C07F9/650947 , C07F9/65121 , C07F9/65122 , C07F9/65127 , C07F9/65128 , C07F9/65335 , C07F9/65515 , C07F9/65583 , C07F9/6561 , C12N9/16 , C12Q1/18 , C12Q1/37 , C12Q1/44 , C40B40/04 , G01N33/5038 , G01N2333/16 , G01N2500/04
摘要： Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
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公开(公告)号：EP0920410B1
公开(公告)日：2002-03-27
申请号：EP97939508.4
申请日：1997-08-22
发明人： KENT, Kenneth, M. , KIM, Choung, U. , MCGEE, Lawrence, R. , MUNGER, John, D. , PRISBE, Ernest, J. , POSTICH, Michael, J. , ROHLOFF, John, C. , KELLY, Daphne, E. , WILLIAMS, Matthew, A. , ZHANG, Lijun
IPC分类号： C07C227/08 , C07C247/14 , C07D317/46 , C07D203/26 , C07D303/40 , C07F7/18 , C07C227/16
CPC分类号： C07D203/26 , C07C227/08 , C07C2601/16 , C07D303/40 , C07D317/46 , Y02P20/55
摘要： The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates such as those having formulas (I)-(IV), such as those having formulas (I)-(IV), useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
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公开(公告)号：EP2268642B1
公开(公告)日：2015-02-25
申请号：EP09734175.4
申请日：2009-04-22
发明人： BUTLER, Thomas , CHO, Aesop , KIM, Choung, U. , SAUNDERS, Oliver, L. , ZHANG, Lijun , PARRISH, Jay
IPC分类号： C07D487/04 , A61K31/395 , A61K31/41 , A61K31/4188 , C07H19/23 , A61K31/7052 , A61P31/12
CPC分类号： C07H19/23 , C07D487/04
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