利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.025 秒)

    POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY
    5.
    发明公开
    POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY 审中-公开
    POLYPEPTID-POLYNUKLEOTID-KOMPLEX UND VERWENDUNG BEI DER GEZIELTEN EFFEKTORREST-BEREITSTELLUNG

    公开(公告)号：EP2655413A1

    公开(公告)日：2013-10-30

    申请号：EP11802941.2

    申请日：2011-12-21

    申请人： F.Hoffmann-La Roche AG

    发明人： GERG, Michael ,  HEINDL, Dieter ,  NIEDERFELLNER, Gerhard ,  SCHAEFER, Wolfgang ,  SCHRAEML, Michael ,  TACKE, Michael

    IPC分类号： C07K16/00 ,  C07K16/32 ,  C07K16/18 ,  A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/46 ,  A61K47/6889 ,  C07K16/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/92 ,  G01N33/573 ,  G01N33/6863

    摘要： Herein is reported a polypeptide-polynucleotide-complex as therapeutic agent and its use as tool for the targeted delivery of an effector moiety. The polynucleotide part of the complex is essentially resistant to proteolytic and enzymatic degradation in vivo. Additionally the polypeptide part specifically binds to a compound or structure such as a tissue or organ, a process or a disease. Thus, one aspect as reported herein is a polypeptide-polynucleotide-complex comprising a) a polypeptide specifically binding to a target and conjugated to a first member of a binding pair, b) a polynucleotide linker conjugated at its first terminus to the second member of the binding pair, and c) an effector moiety conjugated to a polynucleotide that is complementary to at least a part of the polynucleotide linker.

    摘要翻译： 本文报道了作为治疗剂的多肽 - 多核苷酸复合物及其作为用于靶向递送效应子部分的工具的用途。 复合物的多核苷酸部分在体内基本上抗蛋白水解和酶降解。 另外，多肽部分特异性结合化合物或结构如组织或器官，过程或疾病。 因此，本文报道的一个方面是多肽 - 多核苷酸复合物，其包含a）特异性结合靶并与结合对的第一个成员缀合的多肽，b）在其第一个末端缀合至第二个 所述结合对，以及c）与多核苷酸缀合的效应部分，所述多核苷酸与所述多核苷酸接头的至少一部分互补。

    VELOCITY FACTOR
    6.
    发明公开
    VELOCITY FACTOR 有权
    速度系数

    公开(公告)号：EP2470563A1

    公开(公告)日：2012-07-04

    申请号：EP10747844.8

    申请日：2010-08-19

    申请人： F.Hoffmann-La Roche AG

    发明人： SCHRAEML, Michael ,  VON PROFF, Leopold

    IPC分类号： C07K16/00 ,  A61K39/395

    CPC分类号： G01N33/557 ,  C07K16/00 ,  C07K16/461 ,  C07K2317/24 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6854

    摘要： The current invention is directed to the velocity factor. Based on the velocity factor antibodies can be classified, i.e. antibodies can be characterized on their binding properties as e.g. entropic or enthalpic antigen binder. A velocity factor based classification does not require detailed thermodynamic determinations and/or calculations. The velocity factor is the ratio of the antigen-antibody complex association rate constants ka determined at 37 °C and 13 °C. As only two experimental determinations are required to calculate the velocity factor this is a fast and high-throughput suited method.