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1.发明授权
公开(公告)号：EP1171513B1
公开(公告)日：2008-08-13
申请号：EP00917782.5
申请日：2000-03-06
发明人： PICKETT, James, Edward , CARTER, Randall, Lee , WEBB, Jimmy, Lynn , OLSON, Daniel, Robert , HOEFFLIN, Frank, Alex , WANG, Hua
CPC分类号： B32B27/08 , B32B27/20 , B32B27/36 , B32B2305/30 , B32B2307/712 , B32B2367/00 , B32B2605/00 , C08J7/047 , C08J2467/00 , F02B61/045 , Y02P20/582 , Y10T428/1429 , Y10T428/24355 , Y10T428/24802 , Y10T428/24942 , Y10T428/31504 , Y10T428/31507 , Y10T428/31565
摘要： Substantially solvent-free multilayer articles characterized by excellent color retention and gloss retention, solvent resistance and recyclability comprise a substrate layer which may be at least one of polycarbonates, polyesters and ABS and ASA copolymers, and a resinous coating layer which contains resorcinol or alkylresorcinol isophthalate/terephthalate ester units. An intermediate layer may also be present.
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公开(公告)号：EP2809355A2
公开(公告)日：2014-12-10
申请号：EP13701797.6
申请日：2013-01-31
发明人： JOHNSON, Bruce, Fletcher , CARTER, Randall, Lee , RISHEL, Michael, James , DAREY, Mark, Christopher, Patrick , WU, Tao , YANG, Yang , VALLIANT, John, Fitzmaurice , STEPHENSON, Karin, Ann
IPC分类号： A61K51/04 , A61K51/08 , A61K103/10
CPC分类号： A61K51/1093 , A61K51/04 , A61K51/0474 , A61K51/0491 , A61K51/08 , A61K51/088 , C07C311/18
摘要： An embodiment of the invention comprises a ligand of Formula I wherein R1 and R2 are independently an alkyl or cycloalkyl; R3 is and alkyl; X is CO or SO2; Y is (CH2)n, C6H4, (OCH2CH2)n(NHCH2CH2)n and (OCH2CH2CH2)n, or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10. Also included are an imaging agent comprising a compound of Formula I complexed to 99mTc and their method of use to image a subject having a target site using single photon emission computed tomography (SPECT).
摘要翻译： 本发明的一个实施方案包括式I的配体，其中R 1和R 2独立地为烷基或环烷基; R3是和烷基; X为CO或SO2; Y是（CH 2）n，C 6 H 4，（OCH 2 CH 2）n（NHCH 2 CH 2）n和（OCH 2 CH 2 CH 2）n，或其组合; Z是能够与载体缀合的连接基团; 并且n是0至10之间的整数。还包括包含与99mTc复合的式I化合物的成像剂及其用于使用单光子发射计算机断层摄影（SPECT）对具有靶位点的受试者成像的方法。
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公开(公告)号：EP2437792A2
公开(公告)日：2012-04-11
申请号：EP10728034.9
申请日：2010-06-03
发明人： TAN HEHIR, Cristina, Abucay , SICLOVAN, Tiberiu, Mircea , BARNHARDT, Nicole, Evelyn , FISH, Kenneth, Michael , CARTER, Randall, Lee , JOHNSON, Bruce, Fletcher , ZHANG, Rong
IPC分类号： A61K49/10
CPC分类号： A61K49/10
摘要： The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.
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公开(公告)号：EP1115792A1
公开(公告)日：2001-07-18
申请号：EP99938921.6
申请日：1999-07-29
IPC分类号： C08L69/00
摘要： Weatherability of polycarbonates, or of blends of polycarbonates with other polymers such as polyesters, is improved by incorporating therein a thermoplastic arylate polymer comprising units derived from a resorcinol or alkylresorcinol isophthalate-terephthalate. These units may be combined with units derived from a resorcinol or alkylresorcinol ester of a C4-12 aliphatic, alicyclic or mixed aliphatic-alicyclic dicarboxylic acid, such as sebacic acid.
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公开(公告)号：EP2437792B1
公开(公告)日：2015-10-21
申请号：EP10728034.9
申请日：2010-06-03
发明人： TAN HEHIR, Cristina, Abucay , SICLOVAN, Tiberiu, Mircea , BARNHARDT, Nicole, Evelyn , FISH, Kenneth, Michael , CARTER, Randall, Lee , JOHNSON, Bruce, Fletcher , ZHANG, Rong
IPC分类号： A61K49/10
CPC分类号： A61K49/10
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公开(公告)号：EP2413976A1
公开(公告)日：2012-02-08
申请号：EP10710834.2
申请日：2010-03-19
发明人： CARTER, Randall, Lee , CASTLE, Jason, William , FISH, Kenneth, Michael , SOOD, Anup , STAPLES, Natalie, Anne , LEE, Brian Duh-lan
IPC分类号： A61K49/00
CPC分类号： A61K49/0032 , A61K49/0054
摘要： The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethyleneglycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.
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公开(公告)号：EP1115792B1
公开(公告)日：2003-04-23
申请号：EP99938921.6
申请日：1999-07-29
IPC分类号： C08L69/00
摘要： Weatherability of polycarbonates, or of blends of polycarbonates with other polymers such as polyesters, is improved by incorporating therein a thermoplastic arylate polymer comprising units derived from a resorcinol or alkylresorcinol isophthalate-terephthalate. These units may be combined with units derived from a resorcinol or alkylresorcinol ester of a C4-12 aliphatic, alicyclic or mixed aliphatic-alicyclic dicarboxylic acid, such as sebacic acid.
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8.发明公开
公开(公告)号：EP1171513A1
公开(公告)日：2002-01-16
申请号：EP00917782.5
申请日：2000-03-06
发明人： PICKETT, James, Edward , CARTER, Randall, Lee , WEBB, Jimmy, Lynn , OLSON, Daniel, Robert , HOEFFLIN, Frank, Alex , WANG, Hua
CPC分类号： B32B27/08 , B32B27/20 , B32B27/36 , B32B2305/30 , B32B2307/712 , B32B2367/00 , B32B2605/00 , C08J7/047 , C08J2467/00 , F02B61/045 , Y02P20/582 , Y10T428/1429 , Y10T428/24355 , Y10T428/24802 , Y10T428/24942 , Y10T428/31504 , Y10T428/31507 , Y10T428/31565
摘要： Substantially solvent-free multilayer articles characterized by excellent color retention and gloss retention, solvent resistance and recyclability comprise a substrate layer which may be at least one of polycarbonates, polyesters and ABS and ASA copolymers, and a resinous coating layer which contains resorcinol or alkylresorcinol isophthalate/terephthalate ester units. An intermediate layer may also be present.
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