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1.发明授权
公开(公告)号：EP1124879B1
公开(公告)日：2005-11-16
申请号：EP99953218.7
申请日：1999-10-19
发明人： SICLOVAN, Tiberiu, Mircea , WEBB, Jimmy, Lynn , BROWN, Sterling, Bruce , BUCKLEY, Donald, Joseph, Jr. , PICKETT, James, Edward
CPC分类号： C08L69/005 , C08G63/64 , C08L67/00 , C08L67/02 , C08L67/03 , C08L69/00 , C08L79/08 , F02B61/045 , C08L2666/02
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公开(公告)号：EP2437792B1
公开(公告)日：2015-10-21
申请号：EP10728034.9
申请日：2010-06-03
发明人： TAN HEHIR, Cristina, Abucay , SICLOVAN, Tiberiu, Mircea , BARNHARDT, Nicole, Evelyn , FISH, Kenneth, Michael , CARTER, Randall, Lee , JOHNSON, Bruce, Fletcher , ZHANG, Rong
IPC分类号： A61K49/10
CPC分类号： A61K49/10
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公开(公告)号：EP1124878A1
公开(公告)日：2001-08-22
申请号：EP99945533.0
申请日：1999-09-07
发明人： SICLOVAN, Tiberiu, Mircea , WEBB, Jimmy, Lynn , BROWN, Sterling, Bruce , BUCKLEY, Donald, Joseph, Jr. , PICKET, James, Edward
IPC分类号： C08G63/64
CPC分类号： C08L67/00 , C08G63/64 , C08G63/78 , C08G64/18 , C08G2261/126 , C08K3/013 , C08L67/02 , C08L67/03 , C08L69/00 , C08L69/005 , C08L79/08 , F02B61/045
摘要： Block copolyestercarbonates may be prepared by first conducting a reaction between at least one of resorcinol or an alkyl- or haloresorcinol and at least one aromatic dicarboxylic acid dichloride, preferably isophthaloyl dichloride, terephthaloyl dichloride or a mixture thereof, to produce a hydroxy-terminated polyester intermediate, and then conducting a reaction of the intermediate with a carbonate precursor, preferably in the presence of a dihydroxy compound such as bisphenol A. The products have excellent physical properties, including a high degree of weatherability. They may be blended with other polymers such as polycarbonates, poly(alkylene carboxylates), polyarylates, polyetherimides, and addition polymers to improve the weatherability thereof.
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4.发明公开
公开(公告)号：EP1631561A2
公开(公告)日：2006-03-08
申请号：EP04750543.3
申请日：2004-04-23
发明人： MONTALTO, Michael, Christopher , AGDEPPA, Eric, Dustin , SICLOVAN, Tiberiu, Mircea , WILLIAMS, Amy, Casey
IPC分类号： C07D307/80 , C07D307/79 , C07D413/04 , C07D417/04 , C07D405/04 , A61K51/04
CPC分类号： C07D307/79 , A61K49/0002 , C07D307/80 , C07D307/81 , C07D307/82 , C07D405/04 , C07D407/04 , C07D409/04 , C07D413/04 , C07D417/04
摘要： A method for assessing levels of soluble A-beta as an indicator of Alzheimer's disease, and other amyloid-related diseases, in vitro, ex vivo, in vivo, and in situ which employs an imaging agent binds specifically to soluble A-beta and is labeled for detection.
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公开(公告)号：EP1124878B1
公开(公告)日：2004-01-21
申请号：EP99945533.0
申请日：1999-09-07
发明人： SICLOVAN, Tiberiu, Mircea , WEBB, Jimmy, Lynn , BROWN, Sterling, Bruce , BUCKLEY, Donald, Joseph, Jr. , PICKET, James, Edward
IPC分类号： C08G63/64
CPC分类号： C08L67/00 , C08G63/64 , C08G63/78 , C08G64/18 , C08G2261/126 , C08K3/013 , C08L67/02 , C08L67/03 , C08L69/00 , C08L69/005 , C08L79/08 , F02B61/045
摘要： Block copolyestercarbonates may be prepared by first conducting a reaction between at least one of resorcinol or an alkyl- or haloresorcinol and at least one aromatic dicarboxylic acid dichloride, preferably isophthaloyl dichloride, terephthaloyl dichloride or a mixture thereof, to produce a hydroxy-terminated polyester intermediate, and then conducting a reaction of the intermediate with a carbonate precursor, preferably in the presence of a dihydroxy compound such as bisphenol A. The products have excellent physical properties, including a high degree of weatherability. They may be blended with other polymers such as polycarbonates, poly(alkylene carboxylates), polyarylates, polyetherimides, and addition polymers to improve the weatherability thereof.
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公开(公告)号：EP1115792B1
公开(公告)日：2003-04-23
申请号：EP99938921.6
申请日：1999-07-29
IPC分类号： C08L69/00
摘要： Weatherability of polycarbonates, or of blends of polycarbonates with other polymers such as polyesters, is improved by incorporating therein a thermoplastic arylate polymer comprising units derived from a resorcinol or alkylresorcinol isophthalate-terephthalate. These units may be combined with units derived from a resorcinol or alkylresorcinol ester of a C4-12 aliphatic, alicyclic or mixed aliphatic-alicyclic dicarboxylic acid, such as sebacic acid.
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7.发明授权
公开(公告)号：EP1658099B1
公开(公告)日：2008-09-10
申请号：EP04777606.7
申请日：2004-07-06
IPC分类号： A61K51/04
CPC分类号： A61K51/04
摘要： Compounds that include a targeting moiety bound to a regioselective leaving group are useful for preparing imaging agents. The imaging agents can be isolated from byproducts derived from the leaving group based on differences in the chemical attributes (e.g., net charge or polarity) of the molecules or physical attributes of the molecules through the use of a solid support. Methods of producing an imaging agent include the steps of providing a compound that includes a targeting moiety bound to a support via a linker group that contains a site for regioselective substitution of a detectable species, contacting the compound with a solution containing the detectable species, and recovering the imaging agent. Kits which include a first container (5) having therein a solution (31) containing a detectable species and a second container (2) having therein a compound that includes a targeting moiety bound to a support (30) via a leaving group that contains a site for regioselective substitution of the detectable species are also useful for preparing imaging agents.
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公开(公告)号：EP1583987B1
公开(公告)日：2007-05-30
申请号：EP03818839.7
申请日：2003-12-17
发明人： CHISHOLM, Bret, Ja , OLSON, Daniel, Robert , HAY, Grant , MOLAISON, Chris, Anthony , SICLOVAN, Tiberiu, Mircea , RESUE, James, Alan , COYLE, Dennis, Joseph
CPC分类号： G02B1/041 , C08F222/1006 , Y10T428/24355 , Y10T428/24479 , Y10T428/2457 , C08L33/10 , C08L33/08
摘要： Blends of monofunctional and multifunctional (meth)acrylate monomers, optionally in addition to oligomeric multifunctional (meth)acrylates), can be cured by ultraviolet radiation in contact with a photoinitiator to produce optical resinous articles having a glass transition temperature of at least 35 °C and having physical properties making them suitable for use as microstructure-bearing articles.
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9.发明公开
公开(公告)号：EP1658099A1
公开(公告)日：2006-05-24
申请号：EP04777606.7
申请日：2004-07-06
IPC分类号： A61K51/04
CPC分类号： A61K51/04
摘要： Compounds that include a targeting moiety bound to a regioselective leaving group are useful for preparing imaging agents. The imaging agents can be isolated from byproducts derived from the leaving group based on differences in the chemical attributes (e.g., net charge or polarity) of the molecules or physical attributes of the molecules through the use of a solid support. Methods of producing an imaging agent include the steps of providing a compound that includes a targeting moiety bound to a support via a linker group that contains a site for regioselective substitution of a detectable species, contacting the compound with a solution containing the detectable species, and recovering the imaging agent. Kits which include a first container (5) having therein a solution (31) containing a detectable species and a second container (2) having therein a compound that includes a targeting moiety bound to a support (30) via a leaving group that contains a site for regioselective substitution of the detectable species are also useful for preparing imaging agents.
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10.发明授权
公开(公告)号：EP1187867B1
公开(公告)日：2005-08-17
申请号：EP00928904.2
申请日：2000-05-08
发明人： BRUNELLE, Daniel, Joseph , SURIANO, Joseph, Anthony , JANG, Taeseok , SICLOVAN, Tiberiu, Mircea , PICKETT, James, Edward , O'NEIL, Gregory, Allen
IPC分类号： C08G63/19 , C08G63/79 , C08J7/04 , C09D167/03 , B32B27/08
CPC分类号： B32B27/08 , B32B27/06 , B32B27/18 , B32B27/20 , B32B27/36 , B32B27/365 , B32B2307/4026 , B32B2367/00 , B32B2369/00 , B32B2605/00 , C08G63/19 , C08G63/64 , C08G63/676 , C08G63/6956 , C08G63/79 , C08G63/85 , C08J7/047 , C08J2467/00 , C09D167/03 , F02B61/045 , Y10T428/1355 , Y10T428/1359 , Y10T428/25 , Y10T428/254 , Y10T428/2942 , Y10T428/31507 , Y10T428/31565 , Y10T428/31786
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