公开(公告)号：EP1301519B1

公开(公告)日：2015-02-25

申请号：EP01961695.2

申请日：2001-07-20

申请人： GILEAD SCIENCES, INC.

发明人： BECKER, Mark, W. ,  CHAPMAN, Harlan, H. ,  CIHLAR, Tomas ,  EISENBERG, Eugene, J. ,  HE, Gong-Xin ,  KERNAN, Michael, R. ,  LEE, William, A. ,  PRISBE, Ernest, J. ,  ROHLOFF, John, C. ,  SPARACINO, Mark, L.

IPC分类号： C07F9/6561 ,  C07H19/20 ,  G01N33/53 ,  A61K31/675 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07H19/10 ,  C07F9/65616 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/18 ,  G01N33/5011

公开(公告)号：EP2585467B1

公开(公告)日：2016-03-02

申请号：EP11729018.9

申请日：2011-06-23

申请人： Gilead Sciences, Inc.

发明人： BABAOGLU, Kerim ,  BOOJAMRA, Constantine, G. ,  EISENBERG, Eugene, J. ,  HUI, Hon Chung ,  MACKMAN, Richard, L. ,  PARRISH, Jay, P. ,  SANGI, Michael ,  SAUNDERS, Oliver, L. ,  SIEGEL, Dustin ,  SPERANDIO, David ,  YANG, Hai

IPC分类号： C07D487/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/519 ,  A61K31/55 ,  A61K31/551 ,  A61P11/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

公开(公告)号：EP1620445A2

公开(公告)日：2006-02-01

申请号：EP03767521.2

申请日：2003-11-06

申请人： GILEAD SCIENCES, INC.

发明人： BIRKUS, Gabriel ,  CHEN, James, M. ,  CHEN, Xiaowu ,  CIHLAR, Tomas ,  EISENBERG, Eugene, J. ,  HATADA, Marcos ,  HE, Gong-Xin ,  KIM, Choung, U. ,  LEE, William, A. ,  MCDERMOTT, Martin J. ,  SWAMINATHAN, Sundaramoorthi

IPC分类号： C07F9/40 ,  C07F9/6561 ,  G01N33/04

CPC分类号： A61K31/66 ,  A61K31/675 ,  C07D213/75 ,  C07D213/85 ,  C07D231/12 ,  C07D231/20 ,  C07D233/42 ,  C07D239/49 ,  C07D239/80 ,  C07D243/04 ,  C07D265/18 ,  C07D307/68 ,  C07D401/06 ,  C07D403/06 ,  C07D471/14 ,  C07D491/04 ,  C07F9/4006 ,  C07F9/582 ,  C07F9/588 ,  C07F9/645 ,  C07F9/65061 ,  C07F9/65062 ,  C07F9/65067 ,  C07F9/650911 ,  C07F9/650917 ,  C07F9/650947 ,  C07F9/65121 ,  C07F9/65122 ,  C07F9/65127 ,  C07F9/65128 ,  C07F9/65335 ,  C07F9/65515 ,  C07F9/65583 ,  C07F9/6561 ,  C12N9/16 ,  C12Q1/18 ,  C12Q1/37 ,  C12Q1/44 ,  C40B40/04 ,  G01N33/5038 ,  G01N2333/16 ,  G01N2500/04

摘要： The invention relates to methods and compositions for identifying compounds having therapeutic activity against human immunodeficiency virus (HIV).

公开(公告)号：EP2585467A1

公开(公告)日：2013-05-01

申请号：EP11729018.9

申请日：2011-06-23

申请人： Gilead Sciences, Inc.

发明人： BABAOGLU, Kerim ,  BOOJAMRA, Constantine, G. ,  EISENBERG, Eugene, J. ,  HUI, Hon Chung ,  MACKMAN, Richard, L. ,  PARRISH, Jay, P. ,  SANGI, Michael ,  SAUNDERS, Oliver, L. ,  SIEGEL, Dustin ,  SPERANDIO, David ,  YANG, Hai

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/55 ,  A61K31/551 ,  A61P11/00

CPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/551 ,  A61K31/675 ,  A61K45/06 ,  C07D495/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65616

摘要： The invention provides compounds of Formula I or Formula II: (I), (II) or a pharmaceutically acceptable salt or ester, thereof, as described herein. The compounds and compositions thereof are useful for treating Pneumovirinae virus infections. The compounds, compositions, and methods provided are particularly useful for the treatment of Human respiratory syncytial virus infections.

公开(公告)号：EP1301519A2

公开(公告)日：2003-04-16

申请号：EP01961695.2

申请日：2001-07-20

申请人： GILEAD SCIENCES, INC.

发明人： BECKER, Mark, W. ,  CHAPMAN, Harlan, H. ,  CIHLAR, Tomas ,  EISENBERG, Eugene, J. ,  HE, Gong-Xin ,  KERNAN, Michael, R. ,  LEE, William, A. ,  PRISBE, Ernest, J. ,  ROHLOFF, John, C. ,  SPARACINO, Mark, L.

IPC分类号： C07F9/6561 ,  C07H19/20 ,  G01N33/53 ,  A61K31/675 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07H19/10 ,  C07F9/65616 ,  C07H19/20 ,  C07H21/00 ,  C12Q1/18 ,  G01N33/5011

摘要： A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity. This method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.