公开(公告)号：EP2167674B1

公开(公告)日：2018-04-18

申请号：EP08775485.9

申请日：2008-06-13

申请人： Glykos Finland Oy ,  Hankkija Oy

发明人： NIEMELÄ, Ritva ,  SAARINEN, Juhani ,  HELIN, Jari ,  WAKKINEN, Janica

IPC分类号： A23K20/163 ,  A23L29/30 ,  A61K31/715 ,  A61K36/064 ,  A61P1/00 ,  C07H1/08 ,  C12P19/04

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A61K36/064 ,  C07H1/08

摘要： The present invention is directed to a novel saccharide composition isolated from a yeast culture. The invention is also directed to yeast cell based saccharide composition with increased water-solubility. The saccharide compositions disclosed in the invention can be used as nutritional or pharmaceutical additives or as part of nutritional or pharmaceutical composition in order to promote the health of an animal or human subject to which said composition is administered. The invention is also directed to methods of producing said saccharide compositions.

公开(公告)号：EP2091960A2

公开(公告)日：2009-08-26

申请号：EP07823214.7

申请日：2007-10-26

申请人： Glykos Finland Oy

发明人： NATUNEN, Jari ,  HILTUNEN, Jukka ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  AITIO, Olli

IPC分类号： C07K7/06 ,  C07K14/11 ,  A61K38/08 ,  A61K31/7028 ,  C07H15/00 ,  A61P31/16

CPC分类号： A61K39/145 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/64 ,  C07K5/0815 ,  C07K5/0821 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134 ,  G01N33/56983 ,  G01N2333/11 ,  Y10T436/143333

摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes 5 for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.

公开(公告)号：EP2167674A1

公开(公告)日：2010-03-31

申请号：EP08775485.9

申请日：2008-06-13

申请人： Glykos Finland Oy ,  SUOMEN REHU OY

发明人： NIEMELÄ, Ritva ,  SAARINEN, Juhani ,  HELIN, Jari ,  WAKKINEN, Janica

IPC分类号： C12P19/04 ,  A61K36/064 ,  A61K31/715 ,  A23K1/06 ,  A23K1/16 ,  A23L1/09 ,  C07H1/08 ,  A61P1/00

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A61K36/064 ,  C07H1/08

摘要： The present invention is directed to a novel saccharide composition isolated from a yeast culture. The invention is also directed to yeast cell based saccharide composition with increased water-solubility. The saccharide compositions disclosed in the invention can be used as nutritional or pharmaceutical additives or as part of nutritional or pharmaceutical composition in order to promote the health of an animal or human subject to which said composition is administered. The invention is also directed to methods of producing said saccharide compositions.

摘要翻译： 本发明涉及从酵母培养物中分离的新型糖组合物。 本发明还涉及具有增加的水溶性的基于酵母细胞的糖组合物。 本发明公开的糖组合物可以用作营养或药物添加剂或作为营养组合物或药物组合物的一部分，以促进给予所述组合物的动物或人受试者的健康。 本发明还涉及生产所述糖组合物的方法。

公开(公告)号：EP2370475A1

公开(公告)日：2011-10-05

申请号：EP09832997.2

申请日：2009-12-18

申请人： Glykos Finland Oy

发明人： SAARINEN, Juhani ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari ,  HILTUNEN, Jukka

IPC分类号： C08B37/00 ,  A23K1/06 ,  A23L1/09 ,  A61K31/715 ,  A61K36/064 ,  C12P19/04 ,  C12N1/16

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L2/52 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A23L33/10 ,  A23L33/14 ,  C08B37/0003 ,  C08B37/0087

摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.

公开(公告)号：EP2296688A2

公开(公告)日：2011-03-23

申请号：EP08841911.4

申请日：2008-10-24

申请人： Glykos Finland Oy

发明人： NATUNEN, Jari ,  HILTUNEN, Jukka ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  AITIO, Olli

IPC分类号： A61K38/16 ,  A61P31/16 ,  C07K14/11

CPC分类号： A61K38/12 ,  A61K39/12 ,  A61K39/145 ,  A61K47/646 ,  A61K2039/6081 ,  C12N2760/16122 ,  C12N2760/16134 ,  G01N2333/11 ,  G01N2469/20

摘要： The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus, and to conjugates containing one or more such peptide epitopes. The peptide epitopes of the invention are cyclic peptides comprising a 7-mer peptide derived from H1, H3 or H5 hemagglutinin of influenza virus. The 7-mer peptide has a sequence corresponding to the loop sequence at positions 220- 226 of X31-hemagglutinin.

公开(公告)号：EP1871786A1

公开(公告)日：2008-01-02

申请号：EP06725932.5

申请日：2006-04-20

申请人： Glykos Finland Oy

发明人： ÅNGSTRÖM, Jonas ,  MILLER-PODRAZA, Halina ,  PANTZAR, Martina ,  KARLSSON, Karl-Anders ,  BLOMQVIST, Maria ,  HEISKANEN, Annamari ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari ,  SATOMAA, Tero ,  AITIO, Olli

IPC分类号： C07K7/06 ,  C07K14/11 ,  C07K16/10 ,  A61K38/04 ,  A61K31/7028 ,  C07H15/00 ,  A61P31/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07H15/04 ,  C07H15/26 ,  C07K7/06 ,  C07K7/08 ,  C12N2760/16122 ,  C12N2760/16134 ,  G01N33/56983

摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.

公开(公告)号：EP2370475B1

公开(公告)日：2017-02-15

申请号：EP09832997.2

申请日：2009-12-18

申请人： Glykos Finland Oy

发明人： SAARINEN, Juhani ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari ,  HILTUNEN, Jukka

IPC分类号： A23K10/38 ,  A23L29/30

CPC分类号： C12P19/04 ,  A23K20/163 ,  A23L2/52 ,  A23L5/00 ,  A23L29/30 ,  A23L31/10 ,  A23L33/10 ,  A23L33/14 ,  C08B37/0003 ,  C08B37/0087

摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.

摘要翻译： 本发明涉及生产具有糖类成分，包括酵母细胞的水解步骤的方法，回收可溶性部分的免疫刺激组合物的方法。 由此获得的糖类成分具有组合物可作为食物或饮料组分或用作用于治疗特定病症的药物。

公开(公告)号：EP1680133A2

公开(公告)日：2006-07-19

申请号：EP04791421.3

申请日：2004-10-20

申请人： Glykos Finland Oy

发明人： ANGSTRÖM, Jonas ,  MILLER-PODRAZA, Halina ,  PANTZAR, Martina ,  KARLSSON, Karl-Anders ,  BLOMQVIST, Maria ,  HEISKANEN, Annamari ,  NIEMELÄ, Ritva ,  HELIN, Jari ,  NATUNEN, Jari

IPC分类号： A61K31/7028 ,  A61K31/7012 ,  A61P31/12 ,  C07H15/02

CPC分类号： A61K31/7028

摘要： The present invention relates to long branched poly-N-acetyllactosamines and analogous spacer modified divalent sialosides binding to the large binding site of influenza hemagglutinin. The invention further relates to the method for evaluating the potential of a chemical entity to bind to a molecule or molecular complex comprising a large binding site of influenza hemagglutinin. The invention also provides ligands to influenza hemagglutinin for use in the prevention and/or treatment of influenza.