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1.发明公开COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY 有权VERBINDUNGEN ZUR BEHANDLUNG VON SPINALER MUSKELATROPHIE
公开(公告)号：EP2812004A4
公开(公告)日：2015-11-11
申请号：EP13747100
申请日：2013-02-08
发明人： QI HONGYAN , CHOI SOONGYU , DAKKA AMAL , KARP GARY MITCHELL , NARASIMHAN JANA , NARYSHKIN NIKOLAI , TURPOFF ANTHONY A , WEETALL MARLA L , WELCH ELLEN , WOLL MATTHEW G , YANG TIANLE , ZHANG NANJING , ZHANG XIAOYAN , ZHAO XIN , GREEN LUKE , PINARD EMMANUEL , RATNI HASANE
IPC分类号： A61K31/53 , A61K31/4375 , A61K31/519 , A61P25/00 , C07D471/04 , C07D487/04 , C07D519/00
CPC分类号： C07D471/04 , A61K31/519 , C07D239/70 , C07D487/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
摘要翻译： 本文提供了化合物，其组合物，并用于治疗脊髓性肌肉萎缩。
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公开(公告)号：EP3013345A4
公开(公告)日：2016-11-30
申请号：EP14816651
申请日：2014-06-23
发明人： DAKKA AMAL , GREEN LUKE , KARP GARY , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PINARD EMMANUEL , QI HONGYAN , RATNI HASANE , RISHER NICOLE , WEETALL MARLA , WOLL MATTHEW
IPC分类号： A61K31/497 , A61K31/4965 , C07D401/00
CPC分类号： C07D519/00 , C07D263/56 , C07D413/12 , C07D471/04 , C07D487/04 , C07D487/10
摘要： The present invention provides compounds of formula (I) wherein A, B, X, Y, R1 and R2 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments.
摘要翻译： 本发明提供其中A，B，X，Y，R 1和R 2如本文所述的式（I）化合物及其药学上可接受的盐。 此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。
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公开(公告)号：EP2797592A4
公开(公告)日：2016-01-13
申请号：EP12862080
申请日：2012-12-28
发明人： WOLL MATTHEW G , CHEN GUANGMING , CHOI SOONGYU , DAKKA AMAL , HUANG SONG , KARP GARY MITCHELL , LEE CHANG-SUN , LI CHUNSHI , NARASIMHAN JANA , NARYSHKIN NIKOLAI , PAUSHKIN SERGEY , QI HONGYAN , TURPOFF ANTHONY A , WEETALL MARLA L , WELCH ELLEN , YANG TIANLE , ZHANG NANJING , ZHANG XIAOYAN , ZHAO XIN , PINARD EMMANUEL , RATNI HASANE
IPC分类号： A61K31/353 , A61P25/00 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
CPC分类号： C07D487/04 , C07D231/12 , C07D311/16 , C07D311/18 , C07D405/04 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy. In a specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN2 into mRNA that is transcribed from the SMN2 gene. In another specific embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 into mRNA that is transcribed from the SMN1 gene. In yet another embodiment, provided herein are compounds of a form that may be used to modulate the inclusion of exon 7 of SMN1 and SMN2 into mRNA that is transcribed from the SMN1 and SMN2 genes, respectively.
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公开(公告)号：EP2750504A4
公开(公告)日：2015-03-11
申请号：EP12828218
申请日：2012-08-29
申请人： PTC THERAPEUTICS INC
发明人： BRANSTROM ARTHUR , JOSYULA VARA PRASAD VENKATA NAGENDRA , ARNOLD MICHAEL ANDREW , GERASYUTO ALEKSEY I , KARP GARY , WANG JIASHI , BAIRD JOHN DAVID , CHEN GUANGMING , GINZBURG OLYA , YANG TIANLE , SMITH SEAN WESLEY , PEDDI SRINIVASA , WOLL MATTHEW G , ZHANG XIAOYAN , ZHANG NANJING , QI HONGYAN , NARASIMHAN JANA
IPC分类号： A01N43/40
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/5377 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：EP2750505A4
公开(公告)日：2015-08-05
申请号：EP12828566
申请日：2012-08-29
申请人： PTC THERAPEUTICS INC
发明人： BRANSTROM ARTHUR , JOSYULA VARA PRASAD VENKATA NAGENDRA , ARNOLD MICHAEL ANDREW , GERASYUTO ALEKSEY I , KARP GARY , WANG JIASHI , BAIRD JOHN DAVID , PEDDI SRINIVASA , ARASU TAMIL , DU WU , GORSKE YI JIN KIM , TURPOFF ANTHONY ALLAN , WILDE RICHARD GERALD , GINZBURG OLYA , ZHANG NANJING , QI HONGYAN , ZHANG XIAOYAN , SMITH SEAN WESLEY , YANG TIANLE , NARASIMHAN JANA
CPC分类号： C07D515/04 , A01N43/40 , A01N43/50 , A01N43/56 , A01N43/60 , A01N43/647 , A01N43/84 , A01N43/90 , A01N47/38 , A61K31/4412 , A61K31/4427 , A61K31/4439 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D213/80 , C07D401/10 , C07D487/08 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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公开(公告)号：EP2809322A4
公开(公告)日：2015-12-23
申请号：EP13740919
申请日：2013-01-25
申请人： PTC THERAPEUTICS INC
发明人： CHEN GUANGMING , DAKKA AMAL , KARP GARY MITCHELL , LI CHUNSHI , NARASIMHAN JANA , NARYSHKIN NIKOLAI , WEETALL MARLA L , WELCH ELLEN , ZHAO XIN
CPC分类号： C07D513/04 , C07D311/76 , C07D405/04 , C07D405/14 , C07D407/04 , C07D409/04 , C07D409/14 , C07D471/04 , C07D487/04 , C07D497/04
摘要： Provided herein are compounds, compositions thereof and uses therewith for treating spinal muscular atrophy.
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公开(公告)号：EP2750678A4
公开(公告)日：2015-04-08
申请号：EP12826819
申请日：2012-08-29
申请人： PTC THERAPEUTICS INC
发明人： BRANSTROM ARTHUR , JOSYULA VARA PRASAD VENKATA NAGENDRA , ARNOLD MICHAEL ANDREW , GERASYUTO ALEKSEY I , KARP GARY , WANG JIASHI , CHEN GUANGMING , GINZBURG OLYA , HUANG SONG , PEDDI SRINIVASA , WOLL MATTHEW G , SMITH SEAN WESLEY , ZHANG XIAOYAN , ZHANG NANJING , TURPOFF ANTONY ALLAN , NARASIMHAN JANA
IPC分类号： A61K31/473 , C07D221/14 , C07D221/16 , C07D471/04 , C07D471/14 , C07D491/04 , C07D495/04
CPC分类号： C07D491/052 , A61K31/435 , A61K31/4353 , A61K31/436 , A61K31/437 , A61K31/438 , A61K31/473 , A61K31/496 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D221/10 , C07D221/14 , C07D221/16 , C07D401/04 , C07D471/04 , C07D471/14 , C07D491/044 , C07D491/048 , C07D491/14 , C07D495/04 , C07D519/00 , Y02P20/582 , A61K2300/00
摘要： The present description relates to compounds and forms and pharmaceutical compositions thereof and methods for use thereof to treat or ameliorate bacterial infections caused by wild-type and multi-drug resistant Gram-negative and Gram-positive pathogens.
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