公开(公告)号：EP1105474A2

公开(公告)日：2001-06-13

申请号：EP99925624.1

申请日：1999-05-13

申请人： Chiron Corporation ,  HYSEQ, INC.

发明人： WILLIAMS, Lewis, T ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  GIESE, Klaus ,  RANDAZZO, Filippo ,  KENNEDY, Giulia C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  JONES, Lee William ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C07K14/47 ,  C12Q1/68 ,  C07K16/18

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1190058A2

公开(公告)日：2002-03-27

申请号：EP98965500.6

申请日：1998-12-25

申请人： CHIRON CORPORATION ,  Hyseq Inc.

发明人： WILLIAMS, Lewis T. ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  GIESE, Klaus ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA,Veronica ,  JONES, Lee, William ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1268528A2

公开(公告)日：2003-01-02

申请号：EP01962418.8

申请日：2001-03-27

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： WILLIAMS, Lewis T. ,  ESCOBEDO, Jaime ,  INNIS, Michael A. ,  GARCIA, Pablo Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  HE, Zhijun ,  RANDAZZO, Filippo ,  KENNEDY, Giulia C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  JONES, Lee William ,  STACHE-CRAIN, Birgit

IPC分类号： C07K14/00

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variant thereof, to genes corresponding to theses polynucleotides and to proteins expressed by the genes. This invention also relates to diagnostic and therapeutic agents employing such novel polynucleotides, their corresponding genes or gene products, ∫i⊃e.g.∫/i⊃, these genes and proteins, including probes, antisense constructs, and antibodies.

摘要翻译： 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

公开(公告)号：EP1032666A1

公开(公告)日：2000-09-06

申请号：EP98958040.2

申请日：1998-11-23

申请人： HYSEQ, INC.

发明人： DRMANAC, Radoje, T. ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  FORD, John

IPC分类号： C12N15/12 ,  C12N5/10 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/566 ,  A61K38/17

CPC分类号： C07K14/705 ,  A61K38/00

摘要： The present invention provides novel polynucleotides and proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. In particular, the polypeptides of the invention comprise amino acid sequences with similarity to EGF-repeat domains.

摘要翻译： 本发明提供了由这种多核苷酸编码的新的多核苷酸和蛋白质，以及这些多核苷酸和蛋白质的治疗，诊断和研究用途。 特别地，本发明的多肽包含与EGF-重复结构域相似的氨基酸序列。

公开(公告)号：EP1379651A2

公开(公告)日：2004-01-14

申请号：EP01989188.6

申请日：2001-12-07

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： ESCOBEDO, Jaime ,  GARCIA, Pablo Dominguez ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  JONES, William Lee ,  STACHE-CRAIN, Birgit ,  SCOTT, Elizabeth, M.

IPC分类号： C12N15/12 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostics and therapeutics comprising such novel human polynucleotides, their corresponding genes or gene products, including probes, antisense nucleotides, and antibodies. The polynucleotides of the invention correspond to a polynucleotide comprising the sequence information of at least one of SEQ ID NOS:1-1477. The polypeptides of the invention correspond to a polypeptide comprising the amino acid sequence information of at least one of SEQ ID NOS:1478-1568.

公开(公告)号：EP1263956A2

公开(公告)日：2002-12-11

申请号：EP01918557.8

申请日：2001-03-09

申请人： Chiron Corporation ,  Hyseq Inc.

发明人： WILLIAMS, Lewis, T. ,  ESCOBEDO, Jaime ,  INNIS, Michael, A. ,  GARCIA, Pablo, Dominguez ,  SUDDUTH-KLINGER, Julie ,  REINHARD, Christoph ,  RANDAZZO, Filippo ,  KENNEDY, Giulia, C. ,  POT, David ,  KASSAM, Altaf ,  LAMSON, George ,  DRMANAC, Radoje ,  CRKVENJAKOV, Radomir ,  DICKSON, Mark ,  DRMANAC, Snezana ,  LABAT, Ivan ,  LESHKOWITZ, Dena ,  KITA, David ,  GARCIA, Veronica ,  STACHE-CRAIN, Birgit

IPC分类号： C12N15/12 ,  C12N15/10 ,  C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47

摘要： This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

公开(公告)号：EP1144684A2

公开(公告)日：2001-10-17

申请号：EP00903186.5

申请日：2000-01-06

申请人： Hyseq Inc.

发明人： DRMANAC, Radoje ,  DRMANAC, Snezana ,  KITA, David ,  COOKE, Cory ,  XU, Chongjun

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6874 ,  C12Q2537/165

摘要： The invention provides methods for sequencing by hybridization (SBH) using pools of probes that allow greater efficiency in conducting SBH by reducing the number of separate measurements of hybridization signals required to identify each particular nucleotide in a target nucleic acid sequence. The invention also provides pools and sets of pools of probes, as well as methods of generating pools of probes.