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公开(公告)号：EP0828851B1
公开(公告)日：2005-07-20
申请号：EP96916181.9
申请日：1996-05-09
发明人： ROSE, Christiane , VARGAS, Froylan , BOURGEAT, Pierre , SCHWARTZ, Jean-Charles , BISHOP, Paul, Beaumont , BAMBAL, Ramesh, Babarao , GANELLIN, Charon, Robin , LEBLOND, Bertrand , MOORE, Andrew, N., J. , CHAN, Suzanne , LIHUA, Zhao
CPC分类号： C07K5/06052 , A61K38/00 , C07D209/42 , C07K5/06026 , C07K5/06191 , C12Q1/37 , G01N2333/595
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公开(公告)号：EP1042288B1
公开(公告)日：2007-11-07
申请号：EP98966427.1
申请日：1998-12-23
发明人： SCHWARTZ, Jean-Charles , ROSE, Christiane , VARGAS, Froylan, Nathan SmithKline Instit. Neuroch , GANELLIN, Charon, Robin , ZHAO, Lihua , SAMAD, Sanjeeda , CHEN, Yongjun
IPC分类号： C07D209/42 , A61K31/40 , C07D209/60 , C07D491/04
CPC分类号： C07D209/42
摘要： The invention is relative to a compound of formula (I), wherein R?1, R2, R3¿ and n are as defined, together with a process for its preparation. The invention is also relative to the use of a compound (I) as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndromes and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.
摘要翻译： 本发明涉及其中R 1，R 2，R 3和n如上所定义的式（I）化合物及其制备方法。 本发明还涉及化合物（I）作为CCK灭活肽酶三肽基肽酶（TPP II）的抑制剂的用途。 本发明特别涉及进食障碍，肥胖症，精神病综合征和相关精神障碍的治疗。 它还涉及化合物（I）的化妆品用途，特别是用于帮助减肥。
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3.发明公开
公开(公告)号：EP0597088A1
公开(公告)日：1994-05-18
申请号：EP93914482.0
申请日：1993-01-08
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel, 160, av. du Général-Leclerc , GARBARG, Monique , LECOMTE, Jeanne-Marie , GANELLIN, Charon, Robin , TERTIUK, Wasyl 81 The Commons , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , PURAND, Katja
CPC分类号： C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D417/12
摘要： L'invention concerne des dérivés de l'imidazole répondant à la formule générale (IA) ou (IB). Procédés pour la préparation de ces composés et composition pharmaceutique les incorporant.
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4.发明授权
公开(公告)号：EP0597088B1
公开(公告)日：2000-12-06
申请号：EP93914482.0
申请日：1993-01-08
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel, 160, av. du Général-Leclerc , GARBARG, Monique , LECOMTE, Jeanne-Marie , GANELLIN, Charon, Robin , FKYERAT, Abdellatif , TERTIUK, Wasyl 81 The Commons , SCHUNACK, Walter , LIPP, Ralph , STARK, Holger , PURAND, Katja
IPC分类号： C07D233/64 , C07D233/84 , C07D403/12 , C07D401/12 , C07D417/12 , A61K31/415
CPC分类号： C07D233/64 , C07D233/84 , C07D401/12 , C07D403/12 , C07D417/12
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公开(公告)号：EP0760811B1
公开(公告)日：2009-11-18
申请号：EP96908172.8
申请日：1996-03-21
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , QUEMENER, Agnès , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , PURAND, Katja , HÜLS, Annette , REIDEMEISTER, Sybille , ATHMANI, Salah , GANELLIN, Charon, Robin , PELLOUX-LEON, Nadia , TERTIUX, Wasyl , KRAUSE, Michael, C., O. , BASSEM, Sadek
IPC分类号： C07D233/64 , C07D409/12 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , A61K31/415
CPC分类号： C07D233/56 , C07D233/64 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , G01N33/567 , G01N33/74 , G01N2333/726
摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.
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公开(公告)号：EP0760811A1
公开(公告)日：1997-03-12
申请号：EP96908172.0
申请日：1996-03-21
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , QUEMENER, Agnès , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , PURAND, Katja , HÜLS, Annette , REIDEMEISTER, Sybille , ATHMANI, Salah , GANELLIN, Charon, Robin , PELLOUX-LEON, Nadia , TERTIUX, Wasyl , KRAUSE, Michael, C., O. , BASSEM, Sadek
IPC分类号： G01N33 , A61K31 , A61P1 , A61P7 , A61P9 , A61P11 , A61P13 , A61P15 , A61P17 , A61P25 , A61P27 , A61P29 , A61P37 , A61P43 , C07D233 , C07D401 , C07D405 , C07D409 , C07D411 , C07D413
CPC分类号： C07D233/56 , C07D233/64 , C07D405/12 , C07D409/12 , C07D411/12 , C07D413/12 , G01N33/567 , G01N33/74 , G01N2333/726
摘要： Novel imidazole derivatives as histamine receptor H3 antagonists and/or agonists, preparation thereof and therapeutical uses thereof. Chemical compounds for use as histamine receptor H3 agonists, partial agonists or antagonists, having general formula (Ia) or (Ib), the use thereof for making drugs, and methods for revealing the agonist, partial agonist or antagonist activity of such compounds in vivo, are disclosed.
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公开(公告)号：EP0828851A2
公开(公告)日：1998-03-18
申请号：EP96916181.0
申请日：1996-05-09
发明人： ROSE, Christiane , VARGAS, Froylan , BOURGEAT, Pierre , SCHWARTZ, Jean-Charles , BISHOP, Paul, Beaumont , BAMBAL, Ramesh, Babarao , GANELLIN, Charon, Robin , LEBLOND, Bertrand , MOORE, Andrew, N., J. , CHAN, Suzanne , LIHUA, Zhao
CPC分类号： C07K5/06052 , A61K38/00 , C07D209/42 , C07K5/06026 , C07K5/06191 , C12Q1/37 , G01N2333/595
摘要： Inhibitors of a membrane tripeptidylpeptidase responsible for the inactivation of endogenous neuropeptides such as cholecystokinin are described.
摘要翻译： 描述了负责灭活内源神经肽如胆囊收缩素的膜三肽肽酶的抑制剂。
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8.发明公开NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS 有权治疗用途组胺H3受体配体烷基胺中不含咪唑
公开(公告)号：EP1100503A2
公开(公告)日：2001-05-23
申请号：EP99941543.3
申请日：1999-07-29
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , GANELLIN, Charon, Robin , LEURQUIN, Fabien , SIGURD, Elz
IPC分类号： A61K31/4453 , A61K31/40 , A61K31/445 , A61K31/138
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R?1 and R2¿ may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H¿3?-receptors of histamine.
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9.发明授权NON-IMIDAZOLE ALKYLAMINES AS HISTAMINE H 3?-RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS 有权治疗用途组胺H3受体配体烷基胺中不含咪唑
公开(公告)号：EP1100503B1
公开(公告)日：2004-09-22
申请号：EP99941543.3
申请日：1999-07-29
发明人： SCHWARTZ, Jean-Charles , ARRANG, Jean-Michel , GARBARG, Monique , LECOMTE, Jeanne-Marie , LIGNEAU, Xavier , SCHUNACK, Walter, G. , STARK, Holger , GANELLIN, Charon, Robin , LEURQUIN, Fabien , SIGURD, Elz
IPC分类号： A61K31/4453 , A61K31/40 , A61K31/445 , A61K31/138
CPC分类号： C07D213/74 , A61K31/396 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/55 , C07B2200/07 , C07C217/16 , C07C217/20 , C07C217/22 , C07C251/48 , C07C255/54 , C07C2602/10 , C07D207/20 , C07D211/58 , C07D211/60 , C07D211/62 , C07D211/70 , C07D215/38 , C07D215/46 , C07D239/42 , C07D271/06 , C07D277/82 , C07D295/03 , C07D295/088 , C07D295/096 , C07D295/13 , C07D295/185
摘要： Use of a compound of formula (A), wherein: W is a residue which imparts antagonistic and/or agonistic activity at histamine H3-receptors when attached to an imidazole ring in 4(5) position; R?1 and R2¿ may be identical or different and represent each independently a lower alkyl or cycloalkyl, or taken together with the nitrogen atom to which they are attached, a saturated nitrogen-containing ring (i) as defined, a non-aromatic unsaturated nitrogen-containing ring (ii) as defined, a morpholino group, or a N-substituted piperazino group as defined for preparing medicaments acting as antagonists and/or agonists at the H¿3?-receptors of histamine.
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公开(公告)号：EP1042288A1
公开(公告)日：2000-10-11
申请号：EP98966427.1
申请日：1998-12-23
发明人： SCHWARTZ, Jean-Charles , ROSE, Christian , VARGAS, Froylan,Nathan SmithKline Instit. , GANELLIN, Charon, Robin , ZHAO, Lithua , SAMAD, Sanjeeda , CHEN, Yondjun
IPC分类号： C07D209/42 , A61K31/40 , C07D209/60 , C07D491/04
CPC分类号： C07D209/42
摘要： The invention is relative to a compound of formula (I), wherein R?1, R2, R3¿ and n are as defined, together with a process for its preparation. The invention is also relative to the use of a compound (I) as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndromes and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.
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