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1.发明公开
公开(公告)号：EP3685830A1
公开(公告)日：2020-07-29
申请号：EP19219435.5
申请日：2016-05-20
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Universite Paris-Sud , Institut Gustave Roussy (IGR) , Institut Pasteur , ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS , UNIVERSITE PARIS DESCARTES , Université Paris Diderot Paris 7 , Université Pierre et Marie Curie (Paris 6) , Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" I.R.C.C.S
发明人： PERFETTINI, Jean-Luc , PAOLETTI, Audrey , GOUGEON, Marie-Lise , KROEMER, Guido , PIACENTINI, Mauro
摘要： The present invention relates to methods and pharmaceutical composition for modulation polarization and activation of macrophages. In particular, the present invention relates to methods for modulating macrophage M1/M2 polarization in a subject in need thereof comprising administering to the subject a therapeutically effective amount of P2Y2 receptor agonists or antagonists.
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公开(公告)号：EP3156797B1
公开(公告)日：2019-06-12
申请号：EP16191854.5
申请日：2014-08-08
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université Paris Diderot - Paris 7 , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
IPC分类号： G01N33/50
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3.发明公开CORRELATION OF DISEASE ACTIVITY WITH CLONAL EXPANSIONS OF HUMAN PAPILLOMAVIRUS 16-SPECIFIC CD8+ T-CELLS IN PATIENTS WITH SEVERE EROSIVE ORAL LICHEN PLANUS 审中-公开WITH人类克隆性疾病活性的相关性展开式患者乳头瘤病毒16特异性CD8 + T细胞与HEAVY糜烂口腔扁平苔藓
公开(公告)号：EP3156797A1
公开(公告)日：2017-04-19
申请号：EP16191854.5
申请日：2014-08-08
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université Paris Diderot - Paris 7 , ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS
IPC分类号： G01N33/50
CPC分类号： G01N33/56983 , A61K31/675 , A61K39/099 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/572 , A61K2039/575 , A61N5/0613 , C07K14/005 , C07K14/235 , C07K2319/55 , C12N7/00 , C12N2710/20034 , C12Q1/04 , C12Q1/6869 , C12Q1/708 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , G01N33/56972 , G01N2333/025 , G01N2333/7051 , G01N2800/18 , G01N2800/52
摘要： A massive clonal expansion of activated CD8 + T-cells with increased frequency of HPV 16-specific CD8 + T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
摘要翻译： 活化的CD8 + T细胞的一个巨大的克隆扩增与HPV 16特异性CD8 + T细胞的频率增加，其发现是口腔扁平苔藓（OLP）指示HPV感染和dysimmune过程之间的因果关系的特性。 本发明涉及一种用于OLP患者的诊断和治疗的组合物和方法。
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4.发明公开METHODS AND PHARMACEUTICAL COMPOSITION FOR MODULATION POLARIZATION AND ACTIVATION OF MACROPHAGES 审中-公开调节极化和活化巨噬细胞的方法和药物组合物
公开(公告)号：EP3297615A1
公开(公告)日：2018-03-28
申请号：EP16725818.5
申请日：2016-05-20
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Universite Paris-Sud , Institut Gustave Roussy (IGR) , Institut Pasteur , Assistance Publique-Hôpitaux de Paris , Université Paris Descartes , Université Paris Diderot (Paris 7) , Université Pierre et Marie Curie (Paris 6) , Istituto Nazionale per le Malattie Infettive "Lazzaro Spallanzani" I.R.C.C.S
发明人： PERFETTINI, Jean-Luc , PAOLETTI, Audrey , GOUGEON, Marie-Lise , KROEMER, Guido. , PIACENTINI, Mauro.
CPC分类号： A61K31/7072 , A61K31/00 , A61K31/7034 , A61K31/7076 , A61K31/7084 , A61K38/177 , A61K48/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/473 , Y02A50/478
摘要： The present invention relates to methods and pharmaceutical composition for modulation polarization and activation of macrophages. In particular, the present invention relates to methods for modulating macrophage M1/M2 polarization in a subject in need thereof comprising administering to the subject a therapeutically effective amount of P2Y2 receptor agonists or antagonists.
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5.发明公开CORRELATION OF DISEASE ACTIVITY WITH CLONAL EXPANSIONS OF HUMAN PAPILLOMAVIRUS 16-SPECIFIC CD8+ T-CELLS IN PATIENTS WITH SEVERE EROSIVE ORAL LICHEN PLANUS 审中-公开WITH人类克隆性疾病活性的相关性展开式患者乳头瘤病毒16特异性CD8 + T细胞与HEAVY糜烂口腔扁平苔藓
公开(公告)号：EP3030900A2
公开(公告)日：2016-06-15
申请号：EP14748230.1
申请日：2014-08-08
申请人： Institut Pasteur , INSERM - Institut National de la Santé et de la Recherche Médicale , Université Paris Diderot (Paris 7) , Assistance Publique Hôpitaux de Paris
IPC分类号： G01N33/50
CPC分类号： G01N33/56983 , A61K31/675 , A61K39/099 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/572 , A61K2039/575 , A61N5/0613 , C07K14/005 , C07K14/235 , C07K2319/55 , C12N7/00 , C12N2710/20034 , C12Q1/04 , C12Q1/6869 , C12Q1/708 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , G01N33/56972 , G01N2333/025 , G01N2333/7051 , G01N2800/18 , G01N2800/52
摘要： A massive clonal expansion of activated CD8 + T-cells with increased frequency of HPV 16-specific CD8 + T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.
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6.发明授权PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF HIV-1 INFECTIONS 有权药物组合物用于治疗和预防HIV-1感染
公开(公告)号：EP2603587B1
公开(公告)日：2015-10-07
申请号：EP11740683.5
申请日：2011-08-08
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Institut Pasteur , Istituto Nazionale per le Malattie Infettive "La Spallanzani" I.R.C.C.S
IPC分类号： C12N15/113 , A61K31/713 , A61P31/18 , A61K38/46 , A61K31/7088 , A61K31/7105
CPC分类号： A61K39/42 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K38/46 , C12N15/1138 , C12N2310/14 , C12Q1/18 , C12Y306/01005 , G01N33/5041 , G01N33/56988
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7.发明授权MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE 有权监测和感染人类免疫缺陷病毒的抑制通过调节HIV-1复制和生活的HMGB1依赖性激活
公开(公告)号：EP2329266B1
公开(公告)日：2016-03-30
申请号：EP09782934.5
申请日：2009-09-11
申请人： Institut Pasteur
发明人： GOUGEON, Marie-Lise , SAIDI, Hela , MELKI, Maria-Thérèse , POIRIER-BEAUDOIN, Béatrice , SEFFER, Valérie
IPC分类号： G01N33/50
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
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8.发明公开HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS 有权HMGB1和抗HMGB1抗体的预测神经系统疾病
公开(公告)号：EP2545380A2
公开(公告)日：2013-01-16
申请号：EP11710151.9
申请日：2011-03-10
申请人： Institut Pasteur
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/6896 , A61B5/0042 , A61B5/055 , A61B5/15 , A61B5/4029 , A61B5/4064 , A61B5/407 , A61B5/4082 , A61B5/4088 , A61B2010/0077 , G01N33/56988 , G01N33/6854 , G01N2333/16 , G01N2333/52 , G01N2333/522 , G01N2333/523 , G01N2800/28 , G01N2800/56
摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a HIV-infected subject, and the use of this method to monitor the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV. The invention also concerns a prognostic method of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a HIV-infected patient.
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9.发明公开
公开(公告)号：EP3371604A1
公开(公告)日：2018-09-12
申请号：EP16794551.8
申请日：2016-11-03
申请人： Institut Pasteur
发明人： GOUGEON, Marie-Lise , PRADA, Nicole , SAIDI, Héla
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N2333/4703 , G01N2800/24 , G01N2800/26 , G01N2800/28 , G01N2800/2814 , G01N2800/50 , G01N2800/56
摘要： The invention relates to the quantitation of specific antibodies for at least one redox form of High mobility group box 1 (HMGB1) contained in a biological sample, in particular human serum and/or CerebroSpinal Fluid (CSF). The invention also relates to an in vitro method for assessing the state of progression of a disease or a disorder in which HMGB1 is involved, to an in vitro method for the identification of predisposition, prognostic or diagnostic biomarkers of a disease or a disorder in which HMGB1 is involved. The invention also relates to a kit to quantitate said specific antibodies for at least one redox form of HMGB1, in particular human HMGB1.
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10.发明公开AN ASSAY TO DETECT AND QUANTITATE SPECIFIC ANTIBODIES FOR VARIOUS REDOX FORMS OF HMGB1 审中-公开分析法的氧化还原HMGB1的各种形式检测和特异性抗体定量
公开(公告)号：EP3165927A1
公开(公告)日：2017-05-10
申请号：EP15306747.5
申请日：2015-11-03
申请人： INSTITUT PASTEUR
发明人： GOUGEON, Marie-Lise , PRADA, Nicole , SAIDI, Héla
IPC分类号： G01N33/68
CPC分类号： G01N33/6854 , G01N2333/4703 , G01N2800/24 , G01N2800/26 , G01N2800/28 , G01N2800/56
摘要： The invention relates to the quantitation of specific antibodies for at least one redox form of High mobility group box 1 (HMGB1) contained in a biological sample, in particular human serum and/or CerebroSpinal Fluid (CSF). The invention also relates to an in vitro method for assessing the state of progression of a disease or a disorder in which HMGB1 is involved, to an in vitro method for the identification of predisposition, prognostic or diagnostic biomarkers of a disease or a disorder in which HMGB1 is involved. The invention also relates to a kit to quantitate said specific antibodies for at least one redox form of HMGB1, in particular human HMGB1.
摘要翻译： 本发明涉及特异性抗体的定量为包含在生物样品中的高迁移率族中的至少一种氧化还原形式1（HMGB1），特别是人血清和/或脑脊液（CSF）。 因此，本发明涉及在体外方法assesing的疾病或其中HMGB1的病症的进展的状态的参与，在体外方法倾向，预后或疾病的诊断性生物标记的鉴定或其中的病症 HMGB1参与。 人类因此，本发明涉及试剂盒，以定量所述特定抗体特别是对于HMGB1 HMGB1的至少一种氧化还原形式。
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