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1.发明授权LIPOSOMES, ET LEUR UTILISATION NOTAMMENT POUR L'OBTENTION DE COMPOSITIONS IMMUNOMODULATRICES 失效脂质体及其用途，特别用于制造免疫调节介质
公开(公告)号：EP0748214B1
公开(公告)日：1998-10-07
申请号：EP95910590.9
申请日：1995-02-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
IPC分类号： A61K9/127
CPC分类号： A61K39/39 , A61K9/127 , A61K39/0003 , A61K2039/543 , A61K2039/55555 , Y02A50/423
摘要： The liposomes of the invention comprise at least one dual layer comprising a mixture formed by a phospholipid (I) with a flow temperature of 20-25 DEG C, and a phospholipid (II) with a flow temperature of 20-60 DEG C. The invention is characterized in that the molar ratio of phospholipid (I) to phospholipid (II) is 5:95 - 30:70. Said liposomes are for use in the production of vaccines.
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2.发明公开LIPOSOMES, ET LEUR UTILISATION NOTAMMENT POUR L'OBTENTION DE COMPOSITIONS IMMUNOMODULATRICES 失效脂质体及其用途，特别用于制造免疫调节介质
公开(公告)号：EP0748214A1
公开(公告)日：1996-12-18
申请号：EP95910590.0
申请日：1995-02-23
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
CPC分类号： A61K39/39 , A61K9/127 , A61K39/0003 , A61K2039/543 , A61K2039/55555 , Y02A50/423
摘要： The liposomes of the invention comprise at least one dual layer comprising a mixture formed by a phospholipid (I) with a flow temperature of 20-25 °C, and a phospholipid (II) with a flow temperature of 20-60 °C. The invention is characterized in that the molar ratio of phospholipid (I) to phospholipid (II) is 5:95 - 30:70. Said liposomes are for use in the production of vaccines.
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3.发明公开PROTEINES RECOMBINANTES DE L'HEMAGGLUTININE FILAMENTEUSE DE $i(BORDETELLA), NOTAMMENT $i(BORDETELLA PERTUSSIS), PROCEDE POUR LEUR PRODUCTION ET LEURS APPLICATIONS A LA PRODUCTION DE PROTEINES ETRANGERES OU DE PRINCIPES ACTIFS VACCINANTS 失效百日咳，尤其是百日咳百日咳，方法与VERWENDUNGZUR重组PROTEUINE丝状HAEMAGLUTININS产生杂质蛋白或疫苗
公开(公告)号：EP0755447A1
公开(公告)日：1997-01-29
申请号：EP95918030.0
申请日：1995-04-19
申请人： INSTITUT PASTEUR , INSTITUT PASTEUR DE LILLE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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公开(公告)号：EP0941241B1
公开(公告)日：2008-08-06
申请号：EP97944948.5
申请日：1997-10-09
发明人： MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
IPC分类号： C07K14/235 , C07K19/00 , A61K38/16
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
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5.发明授权
公开(公告)号：EP0755447B1
公开(公告)日：2003-07-02
申请号：EP95918030.8
申请日：1995-04-19
发明人： LOCHT, Camille , RENAULD, Geneviève , CAPRON, André , RIVEAU, Gilles , MENOZZI, Franco , JACOB-DUBUISSON, Françoise
IPC分类号： C12N15/31 , C12N15/62 , C07K14/235 , C12N1/21 , A61K39/10
CPC分类号： C07K14/235 , C07K2319/00
摘要： A recombinant DNA containing a sequence (1) coding for a polypeptide heterologous to a filamentous haemagglutinin of Bordetella (Fha) fused within the same reading frame to a sequence (2) located upstream from the first sequence. Said sequence (2) codes for at least a part of the Fha precursor, which part comprises at least the N-terminal region of a truncated mature Fha protein which contains the interaction site of Fha and heparin, and which, when it is itself subjected on its own to the control of a promoter recognised by the cell polymerases of B. Pertussis, and inserted into a B. Pertussis cell culture, is expressed in said culture under the control of said promoter and excreted into the cell culture medium. The invention uses both the abilities of Bordetella, and particularly B. Pertussis, which does not appear to produce extracellular proteases, and the ease with which filamentous haemagglutinins can be isolated from those of the Bordetella synthesising same.
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6.发明授权
公开(公告)号：EP1292333B1
公开(公告)日：2007-02-07
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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公开(公告)号：EP0941241A1
公开(公告)日：1999-09-15
申请号：EP97944948.0
申请日：1997-10-09
发明人： MIELCAREK, Nathalie , LOCHT, Camille , RIVEAU, Gilles , POULAIN-GODEFROY, Odile , CAPRON, André
CPC分类号： C12R1/01 , A61K39/00 , C07K14/235 , Y02A50/423
摘要： The invention concerns a Bordetella strain deficient in the production of toxin and expressing a hybrid protein comprising at least part of the filamentous hemagglutin (FHA) and at least part of a protein heterologous to FHA. The gene coding for the toxin has been eliminated, or at least partially deleted or mutated so as to produce an inactive toxin. This strain can be used as vaccine. The invention also concerns liposomes containing at least part of the FHA protein and at least one protein heterologous to the FHA protein, and the use of FHA for the stimulation of immune responses.
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8.发明公开
公开(公告)号：EP1292333A1
公开(公告)日：2003-03-19
申请号：EP01945376.0
申请日：2001-06-07
CPC分类号： C07K14/235 , A61K39/099 , A61K39/39 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/55511 , A61K2039/55516 , Y02A50/412 , Y02A50/423
摘要： The invention concerns the use of the FHA protein or part of the FHA protein, in free form, as adjuvant of the immune response or as immunostimulant in a human or an animal. The invention also concerns adjuvant and immunostimulatory compositions comprising FHA protein or a fragment thereof, and the use of said compositions for making vaccines.
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