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公开(公告)号：EP2588453A1
公开(公告)日：2013-05-08
申请号：EP11733945.7
申请日：2011-06-28
申请人： IRM LLC , Novartis AG
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng , SHEN, Lichun , LELETI, Rajender Reddy
IPC分类号： C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12 , A61K31/44 , A61P35/00
CPC分类号： C07D417/14 , A61K31/50 , A61K31/541 , A61K45/06 , C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R
1 , R
2 , R
3 are as defined herein.-
公开(公告)号：EP2021328B1
公开(公告)日：2013-04-03
申请号：EP07761921.1
申请日：2007-05-04
申请人： IRM LLC
发明人： GAO, Wenqi , JIANG, Jiqing , WAN, Yongqin , CHENG, Dai , HAN, Dong , WU, Xu , PAN, Shifeng
IPC分类号： C07D413/04
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
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3.发明公开N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权N-（杂）芳基，2-（杂）芳基 - 取代的乙酰胺用作WNT信号切换的调节剂
公开(公告)号：EP2403832A1
公开(公告)日：2012-01-11
申请号：EP10708670.4
申请日：2010-03-01
申请人： IRM LLC
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/44 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway.
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公开(公告)号：EP2167498B1
公开(公告)日：2010-09-15
申请号：EP08770796.4
申请日：2008-06-12
申请人： IRM LLC
发明人： BURSULAYA, Badry , CHENG, Dai , JIANG, Jiqing , KARANEWSKY, Donald, S. , LIU, Yi , PAN, Shifeng , WAN, Yongqin , WANG, Xia , XIE, Yun, Feng , YANG, Yang
IPC分类号： C07D413/14 , C07D413/02 , A61K31/536 , A61P37/02
CPC分类号： C07D413/14 , C07D413/02
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公开(公告)号：EP1814545A2
公开(公告)日：2007-08-08
申请号：EP05851419.1
申请日：2005-11-07
申请人： IRM, LLC
发明人： WAN, Yongqin , MI, Yuan , FAN, Yi , CHENG, Dai , LIU, Yi , GRAY, Nathanael, Schiander , ALBAUGH, Pamela, A.
IPC分类号： A61K31/4178 , C07D403/14
CPC分类号： C07D403/14 , C07D403/06
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC , Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
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6.发明公开COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF RECEPTOR TYROSINE KINASE ACTIVITY 审中-公开化合物和组合物受体酪氨酸激酶活性的抑制剂
公开(公告)号：EP1656378A2
公开(公告)日：2006-05-17
申请号：EP04781114.6
申请日：2004-08-13
申请人： IRM LLC
发明人： CHENG, Dai , DING, Qiang , HAN, Dong , GRAY, Nathanael Schiander , ZHANG, Guobao
IPC分类号： C07D473/40 , C07D473/34 , C07D473/18 , C07D473/16 , A61K31/52 , A61K31/522 , A61P35/02 , A61P35/00 , A61P9/10 , A61P17/06 , A61P11/06
CPC分类号： C07D473/16 , C07D473/18 , C07D473/34 , C07D473/40
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase activity.
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7.发明授权N-(HETERO)ARYL,2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权N-（杂）芳基，2-（杂）芳基 - 取代的乙酰胺用作WNT信号切换的调节剂
公开(公告)号：EP2403832B1
公开(公告)日：2013-11-20
申请号：EP10708670.4
申请日：2010-03-01
申请人： IRM LLC
发明人： CHENG, Dai , ZHANG, Guobao , HAN, Dong , GAO, Wenqi , PAN, Shifeng
IPC分类号： C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/44 , A61P35/00
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway.
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公开(公告)号：EP2167498A1
公开(公告)日：2010-03-31
申请号：EP08770796.4
申请日：2008-06-12
申请人： IRM LLC
发明人： BURSULAYA, Badry , CHENG, Dai , JIANG, Jiqing , KARANEWSKY, Donald, S. , LIU, Yi , PAN, Shifeng , WAN, Yongqin , WANG, Xia , XIE, Yun, Feng , YANG, Yang
IPC分类号： C07D413/14 , C07D413/02 , A61K31/536 , A61P37/02
CPC分类号： C07D413/14 , C07D413/02
摘要： The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5- trisphosphate 3 -kinase B (ITPKb).
摘要翻译： 本发明提供了一类新的式（I）化合物，包含这些化合物的药物组合物以及使用这些化合物治疗或预防与B细胞活性异常或失调相关的疾病或病症，特别是涉及异常活化 肌醇1,4,5-三磷酸3-激酶B（ITPKb）。
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9.发明公开PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES 审中-公开嘌呤化合物和作为激酶抑制剂的组合物与相关方疟原虫疾病中治疗
公开(公告)号：EP2124954A2
公开(公告)日：2009-12-02
申请号：EP08727555.8
申请日：2008-01-10
发明人： WINZELER, Elizabeth , GRAY, Nathanael S. , HAN, Dong , CHENG, Dai
IPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , A61P33/06 , C07D473/16 , C07D473/18 , C07D473/34
CPC分类号： A61K31/52 , A61K31/5377 , A61K31/55 , A61K31/5513 , A61K31/553 , A61K31/662 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D413/12 , C07D417/14 , Y02A50/411
摘要： The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria.
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公开(公告)号：EP2057124A2
公开(公告)日：2009-05-13
申请号：EP07799749.2
申请日：2007-07-20
申请人： IRM, LLC
发明人： PAN, Shifeng , LIU, Yi , XIE, Yun Feng , CHENG, Dai , WAN, Yongqin , HAN, Dong , YANG, Yang , GAO, Wenqi , JIANG, Jiqing , BURSULAYA, Badry , CHAMBERLAIN, Philip , KARANEWSKY, Donald S. , WANG, Xia
IPC分类号： C07D231/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/14 , C07D491/048 , A61K31/415 , A61K31/44 , A61P17/00 , A61P19/02
CPC分类号： C07D401/12 , C07D231/12 , C07D401/14 , C07D413/14 , C07D487/08 , C07D491/04
摘要： The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1, 4, 5-trisphosphate 3-kinase B (ITPKb).
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