公开(公告)号：EP2121598A2

公开(公告)日：2009-11-25

申请号：EP07865576.8

申请日：2007-12-12

申请人： IRM LLC

发明人： LIU, Hong ,  HE, Xiaohui ,  PHILLIPS, Dean ,  ZHU, Xuefeng ,  YANG, Kunyong ,  LAU, Thomas ,  WU, Baogen ,  XIE, Yongping ,  NGUYEN, Truc Ngoc ,  WANG, Xing

IPC分类号： C07D207/40 ,  C07D233/12 ,  C07D233/16 ,  C07D233/32 ,  C07D233/42 ,  C07D233/46 ,  C07D233/50 ,  C07D233/52 ,  C07D263/22 ,  C07D265/32 ,  C07D285/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D413/04

CPC分类号： C07D265/32 ,  C07D207/26 ,  C07D207/40 ,  C07D233/12 ,  C07D233/16 ,  C07D233/32 ,  C07D233/38 ,  C07D233/42 ,  C07D233/46 ,  C07D233/50 ,  C07D233/52 ,  C07D233/74 ,  C07D263/20 ,  C07D263/22 ,  C07D285/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07F7/1856

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

公开(公告)号：EP1807429A2

公开(公告)日：2007-07-18

申请号：EP05813001.4

申请日：2005-10-26

申请人： IRM, LLC

发明人： LIU, Hong ,  HE, Xiaohui ,  CHOI, Ha-Soon ,  YANG, Kunyong ,  WOODMANSEE, David ,  WANG, Zhicheng ,  ELLIS, David, Archer ,  WU, Baogen ,  HE, Yun ,  NGUYEN, Truc, Ngoc

IPC分类号： C07D473/04 ,  C07D473/06 ,  C07D473/18 ,  C07D473/22 ,  C07D473/30 ,  C07D473/34 ,  C07D473/38 ,  A61K31/52 ,  A61K31/522 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/437 ,  A61P25/28 ,  A61P19/02 ,  A61P3/04 ,  A61P9/12 ,  A61P11/06 ,  A61P17/06 ,  A61P25/06 ,  A61P13/12

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D473/30 ,  C07D498/04

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

公开(公告)号：EP1999132B1

公开(公告)日：2012-07-18

申请号：EP07754503.6

申请日：2007-03-30

申请人： IRM LLC

发明人： HE, Xiaohui ,  YANG, Kunyong ,  LIU, Hong ,  ELLIS, David, Archer

IPC分类号： C07D487/04 ,  A61K31/495 ,  A61P3/00 ,  A61P29/00 ,  C07D473/30

CPC分类号： C07D473/30 ,  C07D487/04

摘要： The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

公开(公告)号：EP2459558A2

公开(公告)日：2012-06-06

申请号：EP10747541.0

申请日：2010-07-30

申请人： IRM LLC

发明人： CHE, Jianwei ,  DING, Qiang ,  HE, Xiaohui ,  LIU, Hong ,  LIU, Yahua ,  MICHELLYS, Pierre-Yves ,  OKRAM, Barun ,  WU, Xu ,  YANG, Kunyong ,  ZHU, Xuefeng

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

公开(公告)号：EP2300442A2

公开(公告)日：2011-03-30

申请号：EP09789895.1

申请日：2009-06-23

申请人： IRM LLC

发明人： HE, Xiaohui ,  ZHU, Xuefeng ,  YANG, Kunyong ,  EPPLE, Robert ,  LIU, Hong

IPC分类号： C07D249/06 ,  C07D271/06 ,  C07D277/38 ,  A61K31/426 ,  A61K31/4245 ,  A61K31/4192 ,  A61P3/00

CPC分类号： C07D249/06 ,  C07D271/06 ,  C07D277/38

摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.

公开(公告)号：EP1744755B1

公开(公告)日：2012-12-05

申请号：EP05742278.4

申请日：2005-04-29

申请人： IRM LLC

发明人： LIU, Hong ,  TULLY, David C. ,  CHATTERJEE, Arnab ,  ALPER, Phillip B. ,  WOODMANSEE, David H. ,  MUTNICK, Daniel

IPC分类号： C07D211/66 ,  C07D263/56 ,  C07D273/02 ,  C07D277/64 ,  C07D307/30 ,  C07D295/185

CPC分类号： C07D263/56 ,  C07D211/66 ,  C07D273/02 ,  C07D277/64 ,  C07D295/185 ,  C07D307/30

公开(公告)号：EP2459556A1

公开(公告)日：2012-06-06

申请号：EP10737729.3

申请日：2010-07-27

申请人： IRM LLC

发明人： CHE, Jianwei ,  CHEN, Bei ,  DING, Qiang ,  HAO, Xueshi ,  HE, Xiaohui ,  JIANG, Songchun ,  JIN, Qihui ,  JIN, Yunho ,  LIU, Hong ,  LIU, Yahua ,  OKRAM, Barun ,  UNO, Tetsuo ,  WU, Xu ,  YANG, Kunyong ,  ZHU, Xuefeng

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/4375

摘要： Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.

公开(公告)号：EP1999132A1

公开(公告)日：2008-12-10

申请号：EP07754503.6

申请日：2007-03-30

申请人： IRM, LLC

发明人： HE, Xiaohui ,  YANG, Kunyong ,  LIU, Hong ,  ELLIS, David, Archer

IPC分类号： C07D487/04 ,  A61K31/495 ,  A61P3/00 ,  A61P29/00 ,  C07D473/30

CPC分类号： C07D473/30 ,  C07D487/04

摘要： The invention provides compounds of formula (Ia), (Ic), (Ig) and (Ik), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of Cannabinoid Receptor 1 (CB1).

公开(公告)号：EP1677782A2

公开(公告)日：2006-07-12

申请号：EP04796113.1

申请日：2004-10-21

申请人： IRM LLC

发明人： LIU, Hong ,  ALPER, Phillip, B. ,  MUTNICK, Daniel ,  KARANEWSKY, Donald, S.

IPC分类号： A61K31/34 ,  A61K31/5375 ,  C07D307/04 ,  C07D413/12

CPC分类号： C07D407/12 ,  C07C311/29 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D235/08 ,  C07D295/215 ,  C07D307/33 ,  C07D307/68 ,  C07D405/12

摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

公开(公告)号：EP1658267B1

公开(公告)日：2009-10-14

申请号：EP04809589.7

申请日：2004-08-19

申请人： IRM LLC

发明人： LIU, Hong ,  CHATTERJEE, Arnab ,  TULLY, David, C. ,  ALPER, Phillip, B. ,  BURSULAYA, Badry ,  GUO, Jianhua ,  WOODMANSEE, David ,  MUTNICK, Daniel ,  KARANEWSKY, Donald, S. ,  HE, Yun

IPC分类号： C07D209/08 ,  C07D209/04 ,  C07D265/30 ,  C07D295/13 ,  C07D411/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/404 ,  A61K31/423 ,  A61K31/454 ,  A61K31/5375 ,  A61P35/00

CPC分类号： C07D209/08 ,  C07D261/14 ,  C07D295/18 ,  C07D295/20

摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.