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公开(公告)号：EP2287300A1
公开(公告)日：2011-02-23
申请号：EP09738819.3
申请日：2009-04-28
申请人： Idemitsu Kosan Co., Ltd. , National University Corporation Nara Institute of Science and Technology
IPC分类号： C12N15/09 , A01H5/00 , A61K39/106 , A61K39/108 , A61P31/04 , C07K14/245 , C07K14/25 , C07K14/28 , C07K19/00 , C12N5/10 , A61K39/112
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/517 , C07K14/25 , C07K14/28 , C07K2319/00 , C07K2319/55 , C12N15/8258 , Y02A50/472 , Y02A50/474
摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.
摘要翻译： 使用植物细胞有效地产生细菌毒素蛋白例如志贺毒素蛋白。 使用含有编码杂合蛋白质的DNA的DNA构建体转化植物细胞，其中诸如志贺毒素蛋白质的细菌毒素蛋白质通过具有以下特征（A）和（B）的肽串联连接以产生细菌毒素蛋白质 在植物细胞中：（A）许多氨基酸是12至30; （B）脯氨酸含量为20-35％。
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公开(公告)号：EP2169054B1
公开(公告)日：2015-12-23
申请号：EP08722760.9
申请日：2008-03-25
申请人： Idemitsu Kosan Co., Ltd. , National University Corporation Nara Institute of Science and Technology , National University Corporation Obihiro University of Agriculture and Veterinary Medicine
CPC分类号： C12N15/8258 , A61K39/0258 , A61K2039/517 , A61K2039/552 , C12N15/8257 , Y02A50/474
摘要： A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5'-untranslated region of an alcohol dehydrogenase gene (ADH5'UTR) derived from a plant.
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公开(公告)号：EP2169054A1
公开(公告)日：2010-03-31
申请号：EP08722760.9
申请日：2008-03-25
申请人： Idemitsu Kosan Co., Ltd. , National University Corporation Nara Institute of Science and Technology , National University Corporation Obihiro University of Agriculture and Veterinary Medicine
发明人： SAWADA, Kazutoshi , MATSUI, Takeshi , MAKINO, Sou-ichi , KAWAMOTO, Keiko , YOSHIDA, Mayumi , YOSHIDA, Nobuo , YOSHIDA, Kyoko
CPC分类号： C12N15/8258 , A61K39/0258 , A61K2039/517 , A61K2039/552 , C12N15/8257 , Y02A50/474
摘要： A technology for producing a pig edema disease vaccine at low cost and at high efficiency is developed. Specifically, a gene of a pig edema disease toxin protein (Stx2e protein) is efficiently expressed in plant cells to produce a plant vaccine for pig edema disease at low cost. An Stx2e protein including a secretory signal peptide derived from a plant added at an amino terminus is expressed in cells of a plant such as Lactuca sativa using the 5'-untranslated region of an alcohol dehydrogenase gene (ADH5'UTR) derived from a plant.
摘要翻译： 开发了一种以低成本和高效率生产猪水肿病疫苗的技术。 具体地，猪水肿病毒素蛋白（Stx2e蛋白）的基因在植物细胞中有效表达，以低成本生产用于猪水肿病的植物疫苗。 使用源自植物的醇脱氢酶基因（ADH5'UTR）的5'非翻译区，在包括来自添加在氨基末端的植物的分泌信号肽的Stx2e蛋白在诸如莴苣（Lactuca sativa）的植物的细胞中表达。
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公开(公告)号：EP2287300B1
公开(公告)日：2018-06-27
申请号：EP09738819.3
申请日：2009-04-28
申请人： Idemitsu Kosan Co., Ltd. , National University Corporation Nara Institute of Science and Technology
IPC分类号： C12N15/09 , A01H5/00 , A61K39/106 , A61K39/108 , A61P31/04 , C07K14/245 , C07K14/25 , C07K14/28 , C07K19/00 , C12N5/10 , A61K39/112
CPC分类号： C07K14/245 , A61K39/00 , A61K39/0258 , A61K2039/517 , C07K14/25 , C07K14/28 , C07K2319/00 , C07K2319/55 , C12N15/8258 , Y02A50/474
摘要： A bacterial toxin protein such as a Shiga toxin protein is efficiently produced using plant cells. The plant cells are transformed using a DNA construct containing DNA encoding a hybrid protein in which the bacterial toxin proteins such as the Shiga toxin proteins are tandemly linked through a peptide having the following characteristics (A) and (B) to produce the bacterial toxin protein in the plant cells: (A) a number of amino acids is 12 to 30; and (B) a content of proline is 20 to 35%.
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公开(公告)号：EP3385286A1
公开(公告)日：2018-10-10
申请号：EP16870730.5
申请日：2016-11-30
发明人： SAWADA, Kazutoshi , MATSUI, Takeshi
IPC分类号： C07K19/00 , A01H5/00 , A23K20/195 , A61K36/28 , A61K39/00 , A61P37/04 , C07K14/245 , C07K14/28 , C07K14/405 , C12N15/09
CPC分类号： C07K14/005 , A01H5/00 , A23K20/195 , A61K36/28 , A61K39/00 , C07K14/245 , C07K14/25 , C07K14/28 , C07K14/405 , C07K19/00 , C07K2319/55 , C12N7/00 , C12N15/09 , C12N2750/14322
摘要： According to the invention, immunogenicity of an antigenic peptide is increased by administering a fusion protein, which comprises an antigenic peptide and an adjuvant protein, wherein the adjuvant protein comprises two or more proteins selected from the group consisting of a Shiga toxin 2e B subunit (Stx2eB), an Escherichia coli heat-labile toxin B subunit (LTB), and a cholera toxin B subunit (CTB). or a transformant transformed by a gene coding for the fusion protein.
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公开(公告)号：EP3178930A1
公开(公告)日：2017-06-14
申请号：EP15829878.6
申请日：2015-05-22
IPC分类号： C12N15/09 , A01H5/00 , A61K39/12 , A61P31/12 , C07K14/08 , C07K14/245 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02
CPC分类号： C07K14/005 , A01H5/00 , A61K39/12 , A61K39/385 , A61K2039/542 , A61K2039/543 , A61K2039/552 , A61K2039/6031 , C07K14/08 , C07K14/245 , C07K14/70575 , C07K19/00 , C07K2319/40 , C12N5/10 , C12N7/00 , C12N15/09 , C12N15/8258 , C12N2770/10022 , C12N2770/10034 , C12N2770/10071 , C12P21/02
摘要： An object of the present invention is to optimize, and to increase the accumulation amount of, GP5 antigen, in order to enhance the performance of a PRRS vaccine. The present invention provides a fusion protein comprising an ectodomain (ectGP5) of Glycoprotein 5 (GP5) of porcine reproductive and respiratory syndrome (PRRS) virus, and an adjuvant protein.
摘要翻译： 本发明的一个目的是优化并增加GP5抗原的积聚量，以提高PRRS疫苗的性能。 本发明提供了包含猪繁殖与呼吸综合征（PRRS）病毒的糖蛋白5（GP5）的胞外域（ectGPo）和佐剂蛋白的融合蛋白。
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公开(公告)号：EP3075388A1
公开(公告)日：2016-10-05
申请号：EP14866703.3
申请日：2014-11-25
IPC分类号： A61K39/00 , A23K10/40 , A23K50/00 , A61K38/00 , A61K39/108 , A61K39/112 , A61P1/12 , A61P7/10 , A61P31/04 , A61P37/04 , C07K14/245 , C07K14/25 , C12N15/09
CPC分类号： A61K39/0283 , A23K20/00 , A23K50/30 , A61K38/164 , A61K39/0258 , A61K2039/542 , A61K2039/552 , C07K14/245 , C07K14/25 , C07K2319/00 , Y02A50/474
摘要： The present invention provides an agent for controlling colibacillosis including a fusion protein comprising a subunit of Shiga toxin and a subunit of Escherichia coli heat-labile toxin.
摘要翻译： 本发明提供了用于控制大肠杆菌病的药剂，其包括含有志贺毒素亚基和大肠杆菌不耐热毒素亚基的融合蛋白。
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公开(公告)号：EP3075392A1
公开(公告)日：2016-10-05
申请号：EP14865227.4
申请日：2014-11-25
申请人： Idemitsu Kosan Co., Ltd. , National Institute of Advanced Industrial Science and Technology , Hokusan Co. Ltd.
发明人： SAWADA, Kazutoshi , MATSUI, Takeshi , TAKITA, Eiji , MATSUMURA, Takeshi , ITO, Akira , TABAYASHI, Noriko
IPC分类号： A61K39/112 , A23K10/10 , A23K10/40 , A23K50/50 , A61K38/00 , A61P1/12 , A61P31/04 , C12N15/09
CPC分类号： A61K48/005 , A23K20/00 , A23K50/30 , A61K38/00 , A61K39/0258 , A61K2039/552 , C07K14/245 , C07K14/25 , Y02A50/474
摘要： The present invention provides an agent for controlling Escherichia coli diarrhea comprising a Shiga toxin as an active ingredient.
摘要翻译： 本发明提供一种用于控制大肠杆菌腹泻的药剂，其包含志贺毒素作为活性成分。
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