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公开(公告)号：EP3365428A1
公开(公告)日：2018-08-29
申请号：EP16858294.8
申请日：2016-10-21
发明人： KOEHLER, Karl, R. , HASHINO, Eri
IPC分类号： C12N5/02 , C12N5/0793 , C12N5/0797 , C12N5/22
CPC分类号： C12N5/062 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/415 , C12N2506/02 , C12N2533/52 , C12N2533/90
摘要： Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More particularly, provided herein are methods for obtaining three-dimensional cultures comprising human pluripotent stem cell- derived pre-otic epithelium, otic vesicles, and inner ear sensory epithelia containing hair cells, sensory neurons, and supporting cells.
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公开(公告)号：EP3365037A1
公开(公告)日：2018-08-29
申请号：EP16858318.5
申请日：2016-10-21
发明人： KOEHLER, Karl, R. , LEE, Jiyoon
CPC分类号： C12N5/0698 , A61K35/36 , A61L27/362 , A61L27/3633 , A61L27/3641 , A61L27/3687 , A61L27/3813 , A61L27/3834 , A61L27/3839 , A61L27/3891 , A61L27/3895 , A61L27/52 , A61L27/54 , A61L27/56 , A61L27/58 , A61L27/60 , A61L2300/412 , A61L2300/604 , A61L2300/64 , A61L2430/34 , A61L2430/40 , C12N5/0606 , C12N5/0629 , C12N2501/155 , C12N2501/999 , C12N2506/03 , C12N2506/1346 , C12N2513/00 , C12N2533/76 , C12Q1/6876 , C12Q2600/136
摘要： Provided herein are methods for directing differentiation of human pluripotent stem cells into a three-dimensional multilayered skin composition comprising an epidermal layer, a dermal layer, and a plurality of cells capable of forming a functional hair follicle. Also provided herein are three-dimensional, multilayered engineered skin compositions and methods of using the same for drug screening, for screening compounds for effects on hair growth, and for other applications.
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