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    ENGINEERED LEATHER AND METHODS OF MANUFACTURE THEREOF
    5.
    发明公开
    ENGINEERED LEATHER AND METHODS OF MANUFACTURE THEREOF 审中-公开
    MANERULIERTES LEDER UND VERFAHREN ZUR HERSTELLUNG DAVON

    公开(公告)号：EP2831291A4

    公开(公告)日：2015-11-11

    申请号：EP13769600

    申请日：2013-03-28

    Applicant: MODERN MEADOW INC

    Inventor： FORGACS GABOR ,  MARGA FRANCOISE ,  JAKAB KAROLY

    IPC: C12N5/077 ,  C14B1/30 ,  C14B1/56 ,  C14B7/00 ,  C14C3/00

    CPC classification number: C12N5/0698 ,  B32B9/025 ,  C08H1/06 ,  C08L89/06 ,  C12N5/0062 ,  C12N2533/76 ,  C12N2533/90 ,  C12P21/00 ,  C14B7/00

    Abstract: Engineered animal skin, hide, and leather comprising a plurality of layers of collagen formed by cultured animal collagen-producing (e.g., skin) cells. Layers may be formed by elongate multicellular bodies comprising a plurality of cultured animal cells that are adhered and/or cohered to one another; wherein the elongate multicellular bodies are arranged to form a substantially planar layer for use in formation of engineered animal skin, hide, and leather. Further described herein are methods of forming engineered animal skin, hide, and leather utilizing said layers of animal collagen-producing cells.

    Abstract translation: 包括由培养的产生动物胶原（例如皮肤）的细胞形成的多层胶原的工程动物皮肤，皮革和皮革。 层可以由细长的多细胞体形成，所述多细胞体包含彼此粘附和/或粘附的多个培养的动物细胞; 其中所述细长多细胞体被布置成形成用于形成工程化动物皮肤，皮革和皮革的基本平坦的层。 本文进一步描述的是使用所述动物胶原产生细胞层形成工程化动物皮肤，皮革和皮革的方法。

    MULTILAYERED VASCULAR TUBES
    9.
    发明公开
    MULTILAYERED VASCULAR TUBES 有权
    MULTI-LAYER容器管

    公开(公告)号：EP2547288A2

    公开(公告)日：2013-01-23

    申请号：EP11756951.7

    申请日：2011-03-16

    Applicant: Organovo, Inc.

    Inventor： KHATIWALA, Chirag ,  MURPHY, Keith ,  SHEPHERD, Benjamin

    IPC: A61F2/06 ,  A61L27/38 ,  A61L27/40 ,  C12N5/071

    CPC classification number: A61F2/06 ,  A61L27/3808 ,  A61L27/3813 ,  A61L27/3826 ,  A61L27/507 ,  C12N5/0691 ,  C12N2502/1323 ,  C12N2533/76

    Abstract: Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold. Also described herein are methods of forming said tubes and uses for said tubes including methods for treating patients, comprising providing such a tube into to a patient in need thereof.

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