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1.发明公开
公开(公告)号：EP4347848A1
公开(公告)日：2024-04-10
申请号：EP22730834.3
申请日：2022-05-25
申请人： Sparingvision , Ruhr-Universität Bochum , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , SORBONNE UNIVERSITE
发明人： DALKARA, Deniz , HERLITZE, Stefan , MÜCHER, Brix , KHABOU, Hanen
IPC分类号： C12N15/86 , A61K48/00 , C07K14/705 , A61P27/02
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公开(公告)号：EP4326339A2
公开(公告)日：2024-02-28
申请号：EP22734477.7
申请日：2022-04-20
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Sparingvision , Centre National de la Recherche Scientifique (CNRS) , SORBONNE UNIVERSITE
IPC分类号： A61K48/00 , C12N15/86 , C12N15/864 , A61P27/02 , C07K14/435
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3.发明公开
公开(公告)号：EP4132961A1
公开(公告)日：2023-02-15
申请号：EP20736739.2
申请日：2020-07-10
申请人： Sorbonne Université , Centre national de la recherche scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , Ruhr-Universität Bochum , Centre Hospitalier National d'Ophtalmologie Quinze-Vingts
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公开(公告)号：EP3570895A1
公开(公告)日：2019-11-27
申请号：EP18701288.5
申请日：2018-01-16
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5.发明公开METHODS FOR EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE RETINA OF A SUBJECT 审中-公开表达的目的多核苷酸的一个人的视网膜方法
公开(公告)号：EP3013946A1
公开(公告)日：2016-05-04
申请号：EP14733199.5
申请日：2014-06-27
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Pierre et Marie Curie (Paris 6) , Centre National de la Recherche Scientifique (CNRS)
CPC分类号： A61K48/0075 , A61K9/0048 , A61K31/713 , A61K38/465 , C07K14/4703 , C12N7/00 , C12N15/113 , C12N15/86 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171 , C12Y301/00
摘要： Provided herein are methods for expressing a polynucleotide of interest in the retina of a subject. In particular, a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression is provided.
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6.发明公开
公开(公告)号：EP4357359A1
公开(公告)日：2024-04-24
申请号：EP23205005.4
申请日：2023-10-20
申请人： Sparingvision , Ruhr-Universität Bochum , Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique , SORBONNE UNIVERSITE
发明人： DALKARA, Deniz , KHABOU, Hanen , MÜCHER, Brix , HERLITZE, Stefan
IPC分类号： C07K14/705 , A61K31/00 , A61K33/00 , A61K38/00 , A61P1/00 , A61P25/00 , A61P27/02 , C12N15/00 , C12N15/52 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00 , A61P1/00 , C12N15/00 , C12N15/52 , A61K31/7088 , A61K9/0019 , A61K9/0048
摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated inwardly rectifying potassium channel (GIRK), in particular GIRK4 S143T, activated by G proteins recruited by cone opsin expressed in degenerating cones.
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公开(公告)号：EP4259804A1
公开(公告)日：2023-10-18
申请号：EP20851388.7
申请日：2020-12-08
申请人： SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM
发明人： ZEITZ, Christina , DALKARA, Deniz , VARIN, Juliette , AUDO, Isabelle , PICAUD, Serge , SAHEL, José-Alain
IPC分类号： C12N15/864
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8.发明公开
公开(公告)号：EP4163296A1
公开(公告)日：2023-04-12
申请号：EP22200939.1
申请日：2022-10-11
申请人： Sparingvision
发明人： DALKARA, Deniz , SIMON, Cardillia-Joe , HERLITZE, Stephan , SAHEL, José-Alain , AUDO, Isabelle , PICAUD, Serge , BERTIN, Stéphane
IPC分类号： C07K14/705 , A61P27/02 , A61K38/17 , A61K48/00
摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated-K+ channel (GIRK), in particular GIRK2, activated by G proteins recruited by cone opsin expressed in degenerating cones for use in the treatment of patients with RCD.
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