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1.发明公开
公开(公告)号：EP4132961A1
公开(公告)日：2023-02-15
申请号：EP20736739.2
申请日：2020-07-10
申请人： Sorbonne Université , Centre national de la recherche scientifique , Institut National de la Santé et de la Recherche Médicale (INSERM) , Ruhr-Universität Bochum , Centre Hospitalier National d'Ophtalmologie Quinze-Vingts
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2.发明公开
公开(公告)号：EP4347848A1
公开(公告)日：2024-04-10
申请号：EP22730834.3
申请日：2022-05-25
申请人： Sparingvision , Ruhr-Universität Bochum , Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , SORBONNE UNIVERSITE
发明人： DALKARA, Deniz , HERLITZE, Stefan , MÜCHER, Brix , KHABOU, Hanen
IPC分类号： C12N15/86 , A61K48/00 , C07K14/705 , A61P27/02
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公开(公告)号：EP4326339A2
公开(公告)日：2024-02-28
申请号：EP22734477.7
申请日：2022-04-20
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Sparingvision , Centre National de la Recherche Scientifique (CNRS) , SORBONNE UNIVERSITE
IPC分类号： A61K48/00 , C12N15/86 , C12N15/864 , A61P27/02 , C07K14/435
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4.发明公开
公开(公告)号：EP4357359A1
公开(公告)日：2024-04-24
申请号：EP23205005.4
申请日：2023-10-20
申请人： Sparingvision , Ruhr-Universität Bochum , Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique , SORBONNE UNIVERSITE
发明人： DALKARA, Deniz , KHABOU, Hanen , MÜCHER, Brix , HERLITZE, Stefan
IPC分类号： C07K14/705 , A61K31/00 , A61K33/00 , A61K38/00 , A61P1/00 , A61P25/00 , A61P27/02 , C12N15/00 , C12N15/52 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00 , A61P1/00 , C12N15/00 , C12N15/52 , A61K31/7088 , A61K9/0019 , A61K9/0048
摘要： The present invention concerns a new gene therapy approach to increase light-sensitivity in degenerating cones in advanced stages of rod-cone dystrophy (RCD) mediated by G-protein-gated inwardly rectifying potassium channel (GIRK), in particular GIRK4 S143T, activated by G proteins recruited by cone opsin expressed in degenerating cones.
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5.发明公开
公开(公告)号：EP3516046A1
公开(公告)日：2019-07-31
申请号：EP17771767.5
申请日：2017-09-22
申请人： Sorbonne Université , Centre National de la Recherche Scientifique , INSERM (Institut National de la Santé et de la Recherche Médicale)
发明人： DUEBEL, Jens , ADER, Marius , CHAFFIOL, Antoine , GARITA-HERNANDEZ, Marcela , LAMPIC, Marusa , DALKARA, Deniz , GOUREAU, Olivier , SAHEL, José-Alain
IPC分类号： C12N5/0793 , A61K35/30 , C12N15/85 , C12N15/861
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公开(公告)号：EP3448411A1
公开(公告)日：2019-03-06
申请号：EP17734136.9
申请日：2017-04-28
申请人： Gensight Biologics SA , Sorbonne Université , Centre National de la Recherche Scientifique , Institut National de la Santé et de la Recherche Médicale
发明人： PRUNEAU, Didier , DOUAR, Anne , DALKARA, Deniz , DUEBEL, Jens , CAPLETTE, Romain , GAUVAIN, Gregory , DESROSIERS, Melissa , SAHEL, Jose , PICAUD, Serge
IPC分类号： A61K38/16 , C07K14/405 , C12N15/62 , C12N15/86
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公开(公告)号：EP3384036A1
公开(公告)日：2018-10-10
申请号：EP16806078.8
申请日：2016-12-05
申请人： Sorbonne Université , INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique , Friedrich Miescher Institute for Biomedical Research
发明人： DALKARA, Deniz , PICAUD, Serge , DESROSIERS, Melissa , SAHEL, José-Alain , DUEBEL, Jens , BEMELMANS, Alexis , ROSKA, Botond
IPC分类号： C12N15/861
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/711 , A61K48/0058 , A61P25/02 , A61P25/28 , A61P27/00 , C12N15/85 , C12N2750/14132 , C12N2750/14143 , C12N2750/14145 , C12N2840/105
摘要： The present invention relates to a nucleic acid sequence derived from the regulatory region of the human gamma-synuclein gene and having a promoter activity in retinal ganglion cells. The present invention also relates to expression cassettes or vectors comprising said promoter operably linked to a nucleic acid sequence encoding a polypeptide of interest as well as viral particles or host cells comprising said expression cassette or vector. The present invention also relates to the use of said expression cassettes, vectors, viral particles or cells in the treatment of ocular disease, in particular ocular disease associated with retinal ganglion cell or photoreceptor cell degeneration.
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公开(公告)号：EP3013946B8
公开(公告)日：2019-04-10
申请号：EP14733199.5
申请日：2014-06-27
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公开(公告)号：EP4259804A1
公开(公告)日：2023-10-18
申请号：EP20851388.7
申请日：2020-12-08
申请人： SORBONNE UNIVERSITE , Centre National de la Recherche Scientifique , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM
发明人： ZEITZ, Christina , DALKARA, Deniz , VARIN, Juliette , AUDO, Isabelle , PICAUD, Serge , SAHEL, José-Alain
IPC分类号： C12N15/864
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10.发明公开METHODS FOR EXPRESSING A POLYNUCLEOTIDE OF INTEREST IN THE RETINA OF A SUBJECT 审中-公开表达的目的多核苷酸的一个人的视网膜方法
公开(公告)号：EP3013946A1
公开(公告)日：2016-05-04
申请号：EP14733199.5
申请日：2014-06-27
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Pierre et Marie Curie (Paris 6) , Centre National de la Recherche Scientifique (CNRS)
CPC分类号： A61K48/0075 , A61K9/0048 , A61K31/713 , A61K38/465 , C07K14/4703 , C12N7/00 , C12N15/113 , C12N15/86 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2750/14142 , C12N2750/14143 , C12N2750/14171 , C12Y301/00
摘要： Provided herein are methods for expressing a polynucleotide of interest in the retina of a subject. In particular, a method for expressing a polynucleotide of interest in the retina of a subject comprising the step consisting of injecting into the vitreous an amount of a vector containing the polynucleotide of interest in combination with an amount of an inhibitor of Dp71 expression is provided.
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