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1.发明授权CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF 有权晶体结构克氏锥虫脯氨酸消旋酶（TcPRACA）及其使用
公开(公告)号：EP1629092B1
公开(公告)日：2010-12-01
申请号：EP04743784.3
申请日：2004-06-01
发明人： MINOPRIO, Paola , ALZARI, Pedro , BUSCHIAZZO, Alejandro , DEGRAVE, Wim , GREGOIRE, Christophe, Inst. Gulbenkian de Ciencia , CHAMOND, Nathalie , BERNEMAN, Armand
IPC分类号： C07K14/44
CPC分类号： C12N9/90 , C07K2299/00 , C30B7/00 , C30B29/58 , Y02A90/26
摘要： The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
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2.发明授权OB-FOLD USED AS SCAFFOLD FOR ENGINEERING NEW SPECIFIC BINDERS 有权ALSGERÜSTVERWENDETE OB-FALTUNG ZUR ENTWICKLUNG NEUER SPEZIFISCHER BINDEMITTEL
公开(公告)号：EP2099817B1
公开(公告)日：2015-02-11
申请号：EP07872052.1
申请日：2007-12-04
发明人： PECORARI, Frédéric , ALZARI, Pedro
IPC分类号： C07K16/12 , C07K16/42 , C07K14/195 , C12N15/10
CPC分类号： C12N15/1041 , C07K14/195 , C07K16/1228 , C07K16/1232 , C07K16/4283 , C07K2318/20 , C40B30/04
摘要： The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
摘要翻译： 本发明涉及蛋白质工程领域，并提供用于获得特异性结合选自多种配体家族中的靶标的稳定分子的方法。 特别地，本发明提供了通过以OB折叠蛋白作为起始分子的组合突变/选择方法获得特异性结合目的靶标的分子的方法。 特别地，感兴趣的靶可以是用作起始分子的OB折叠蛋白的天然靶的不同化学性质。
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公开(公告)号：EP2099817A2
公开(公告)日：2009-09-16
申请号：EP07872052.1
申请日：2007-12-04
发明人： PECORARI, Frédéric , ALZARI, Pedro
IPC分类号： C07K14/195
CPC分类号： C12N15/1041 , C07K14/195 , C07K16/1228 , C07K16/1232 , C07K16/4283 , C07K2318/20 , C40B30/04
摘要： The present invention pertains to the field of protein engineering, and provides means for obtaining stable molecules that specifically bind to a target selected amongst a large variety of ligands families. In particular, the present invention provides methods for obtaining a molecule specifically binding to a target of interest, through a combinatorial mutation/selection approach with an OB-fold protein as a starting molecule. In particular, the target of interest can be of a different chemical nature form that of the native target of the OB-fold protein used as the starting molecule.
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4.发明公开CRYSTALLOGRAPHIC STRUCTURE OF TRYPANOSOMA CRUZI PROLINE RACEMASE (TcPRACA) AND USES THEREOF 有权晶体结构克氏锥虫脯氨酸消旋酶（TcPRACA）及其使用
公开(公告)号：EP1629092A2
公开(公告)日：2006-03-01
申请号：EP04743784.3
申请日：2004-06-01
发明人： MINOPRIO, Paola , ALZARI, Pedro , BUSCHIAZZO, Alejandro , DEGRAVE, Wim , GREGOIRE, Christophe, Inst. Gulbenkian de Cienca , CHAMOND, Nathalie , BERNEMAN, Armand
IPC分类号： C12N9/00
CPC分类号： C12N9/90 , C07K2299/00 , C30B7/00 , C30B29/58 , Y02A90/26
摘要： The present invention provides the crystal structure of the Trypanosoma cruzi PRACA proline racemase. Methods of modelling drugs that treat or prevent infection by T. cruzi are also provided, as are the drugs that are identified.
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5.发明授权
公开(公告)号：EP1097173B1
公开(公告)日：2008-05-21
申请号：EP99936898.8
申请日：1999-07-16
申请人： INSTITUT PASTEUR
发明人： THEZE, Jacques , ECKENBERG, Ralph , MOREAU, Jean-Louis , GOLDBERG, Michel , ROSE, Thierry , ALZARI, Pedro , MAZIE, Jean-Claude
CPC分类号： C07K14/55 , A61K38/00 , A61K2039/505 , C07K16/246 , C07K2317/34 , C07K2317/73 , G01N33/6869 , Y02A50/473 , Y10S514/885
摘要： The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of IL-2. The invention also relates to DNA sequences encoding the IL-2 peptides, and to methods of using the IL-2 peptides and derivatives and anti-IL-2 antibodies to modulate or mimic or antagonize the biological activities of IL-2 in vivo and to assay for the presence and activity of the IL-2 receptor.
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6.发明公开PKNB KINASE AND PSTP PHOSPHATASE AND METHODS OF IDENTIFYING INHIBITORY SUBSTANCES 审中-公开PknB激酶和PSTP - 磷酸酶和一种用于识别抑制剂
公开(公告)号：EP1649044A1
公开(公告)日：2006-04-26
申请号：EP04769457.5
申请日：2004-07-19
申请人： INSTITUT PASTEUR
CPC分类号： C12Q1/18 , C12Q1/42 , C12Q1/485 , G01N2333/35 , G01N2333/912 , G01N2500/10
摘要： The present invention relates to a pknB kinase and a pstP phosphatase as well as their use for identifying antibacterial substances.
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7.发明公开ACTIVE OR PASSIVE IMMUNIZATION AGAINST PROAPOPTOTIC NEUROTROPHINS FOR THE TREATMENT OR PREVENTION OF NEURODEGENERATIVE DESEASES 审中-公开主动或被动免疫对治疗或预防神经退行性疾病的神经营养因子凋亡
公开(公告)号：EP1648503A2
公开(公告)日：2006-04-26
申请号：EP04764149.3
申请日：2004-07-23
发明人： BARBEITO, Luis Hector , ESTEVEZ, Alvaro, G., Dept. of Phys. & Biophysics , BECKMAN, Joseph, S. , PEHAR, Mariana, Inst. Inv. Biologicas Clemente E. , ALZARI, Pedro , CASSINA, Maria Patricia Departamento de Histologia
IPC分类号： A61K39/385 , A61P25/28 , A61K39/395 , A61K39/39 , C12N15/12 , C12N15/63 , C07K16/22 , C07K14/475 , A01K67/027
CPC分类号： C07K14/475 , A61K38/185 , A61K39/0005 , A61K39/0007 , A61K48/00 , A61K2039/505 , C07K16/22
摘要： The present invention relates to novel methods for combatting cell degeneration or dysfunction resulting from neuroinflammatory conditions. The invention especially relates to the use, in the preparation of a medicament for the treatment of neurodegenerative disease associated with neuroinflammation, of an immunogenic compound which is capable of inducing an immune response against a proapoptotic neurotrophin, or an effective amount of a hapten combined with appropriate carriers and/or adjuvants to render the resulting combination capable of inducing an immune response against a proapoptotic neurotrophin. Also disclosed are compositions for the active or passive immunization against neuronal or glial cell apoptosis caused by neuroinflammantion as well as methods and means useful for said active or passive immunization.
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8.发明公开PEPTIDES OF IL-2 AND DERIVATIVES THEREOF AND THEIR USE AS THERAPEUTIC AGENTS 有权AS治疗物质的IL-2肽和肽衍生物的用途
公开(公告)号：EP1097173A1
公开(公告)日：2001-05-09
申请号：EP99936898.8
申请日：1999-07-16
申请人： INSTITUT PASTEUR
发明人： THEZE, Jacques , ECKENBERG, Ralph , MOREAU, Jean-Louis , GOLDBERG, Michel , ROSE, Thierry , ALZARI, Pedro , MAZIE, Jean-Claude
CPC分类号： C07K14/55 , A61K38/00 , A61K2039/505 , C07K16/246 , C07K2317/34 , C07K2317/73 , G01N33/6869 , Y02A50/473 , Y10S514/885
摘要： The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of IL-2. The invention also relates to DNA sequences encoding the IL-2 peptides, and to methods of using the IL-2 peptides and derivatives and anti-IL-2 antibodies to modulate or mimic or antagonize the biological activities of IL-2 in vivo and to assay for the presence and activity of the IL-2 receptor.
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