专利检索 ap:("Institute of Pharmacology AND Toxicology Academy of Military Medical Sciences P.L.A. China" OR "Peking University") AND inv:"ZHOU, Xinbo" 第 1 页

1.

发明公开
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF 有权
标题翻译：哌嗪基嘧啶衍生物，其制备方法和用途

公开(公告)号：EP2805947A1

公开(公告)日：2014-11-26

申请号：EP13738361.8

申请日：2013-01-15

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University

发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying

IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00

CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12

摘要： Provided are piperazinyl pyrimidine derivatives of formula I having CCR 4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR 4 -related diseases.

摘要翻译： 本发明提供了具有CCR4拮抗作用的式I的哌嗪基嘧啶衍生物及其制备方法，药物组合物和其在制备药物中的用途。该药物可用于治疗和预防CCR4相关疾病。

2.

发明授权
PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF 有权
标题翻译：哌嗪基嘧啶衍生物，其制备方法和用途

公开(公告)号：EP2805947B1

公开(公告)日：2017-02-22

申请号：EP13738361.8

申请日：2013-01-15

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University

发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying

IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00 , C07D403/12 , C07D239/50 , C07D417/12 , A61P29/00 , A61P37/00

CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12

3.

发明授权
RAPAMYCIN DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITION AND USES THEREOF 有权

公开(公告)号：EP3153165B1

公开(公告)日：2020-05-06

申请号：EP15803906.5

申请日：2015-06-03

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： ZHONG, Wu , LI, Song , CAO, Shuang , CAO, Ruiyuan , XIAO, Junhai , ZHOU, Xinbo , LI, Xingzhou

IPC分类号： A61K31/395 , C07D405/14 , C07D405/00 , C07D491/18

4.

发明授权
DERIVATIVE OF HOMOSERINE LACTONE, AND PREPARATION METHOD AND USE THEREOF 有权

公开(公告)号：EP2955174B1

公开(公告)日：2019-02-27

申请号：EP13874809.0

申请日：2013-12-10

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei

IPC分类号： C07D307/33 , A61K31/635 , A61P31/04

5.

发明授权
N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF 有权

公开(公告)号：EP3085701B1

公开(公告)日：2019-02-20

申请号：EP14872369.5

申请日：2014-12-19

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui , WANG, Lili

IPC分类号： C07D401/04 , C07D417/06 , A61K31/506 , A61K31/454 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/00

6.

发明授权
THIAZINE AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权
标题翻译： THAZINAMIDDERIVAT SOWIE PHARMAZEUTISCHE ZUSAMMENSETZUNG UND VERWENDUNG DAVON

公开(公告)号：EP2889293B1

公开(公告)日：2017-04-26

申请号：EP12883262.3

申请日：2012-08-24

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： LI, Song , XIAO, Junhai , HAN, Dan , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui , JIANG, Dan , CHEN, Wei , LIU, Hongying

IPC分类号： C07D279/12 , A61K31/54 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/14

CPC分类号： C07D279/12

7.

发明公开
NOVEL PIPERIDINE CARBOXAMIDE COMPOUND, PREPARATION METHOD, AND USAGE THEREOF 有权
标题翻译：新的哌啶甲酰胺化合物，其制备方法和用途

公开(公告)号：EP3085700A1

公开(公告)日：2016-10-26

申请号：EP14871647.5

申请日：2014-12-19

申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

发明人： ZHONG, Wu , LI, Song , ZENG, Yanqun , XIAO, Junhai , ZHOU, Xinbo , ZHENG, Zhibing , LI, Xingzhou , WANG, Xiaokui

IPC分类号： C07D401/04 , C07D401/14 , C07D409/14 , A61K31/506 , A61P35/00 , A61P25/28 , A61P37/06 , A61P31/04

CPC分类号： C07D401/04 , A61K31/404 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D409/14 , A61K2300/00

摘要： The present invention provides a compound of a general formula I, a stereomeride, pharmaceutically acceptable salt or a solvate thereof, a preparation method thereof, and usages in preparing medicines for preventing and/or treating diseases or symptoms caused by drug-resistant tumors or drug-resistant bacteria and in preparing medicines for preventing and/or treating diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection. Preferably, the diseases or symptoms related to tumors, neurodegenerative diseases, allogeneic transplantation rejection, and infection are diseases or symptoms caused by a heat shock protein 70 (Hsp70). The compound in the present invention is used for overcoming a difficult problem of drug resistance of tumors, improves the effect of tumor treatment, and provides a new medical strategy for clinical tumor treatment.

摘要翻译： 本发明提供了通式I的化合物，其立体异构体，药学上可接受的盐或溶剂合物，其制备方法以及用于制备用于预防和/或治疗由耐药肿瘤或药物引起的疾病或症状的药物的用途和制备用于预防和/或治疗与肿瘤，神经退行性疾病，异体移植排斥和感染有关的疾病或症状的药物。优选地，与肿瘤，神经退行性疾病，同种异体移植排斥和感染有关的疾病或症状是由热休克蛋白70（Hsp70）引起的疾病或症状。本发明化合物用于克服肿瘤耐药性难题，提高肿瘤治疗效果，为临床肿瘤治疗提供了新的医学策略。