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公开(公告)号：EP2805947A1
公开(公告)日：2014-11-26
申请号：EP13738361.8
申请日：2013-01-15
申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University
发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying
IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00
CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12
摘要： Provided are piperazinyl pyrimidine derivatives of formula I having CCR 4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR 4 -related diseases.
摘要翻译： 本发明提供了具有CCR4拮抗作用的式I的哌嗪基嘧啶衍生物及其制备方法，药物组合物和其在制备药物中的用途。 该药物可用于治疗和预防CCR4相关疾病。
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公开(公告)号：EP2805947B1
公开(公告)日：2017-02-22
申请号：EP13738361.8
申请日：2013-01-15
申请人： Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China , Peking University
发明人： LI, Song , WANG, Ying , XIAO, Junhai , MA, Dalong , GONG, Hongwei , QI, Hui , WANG, Lili , LING, Xiaomei , ZHENG, Zhibing , ZHANG, Yang , ZHONG, Wu , LI, Meina , XIE, Yunde , XU, Enquan , LI, Xingzhou , MA, Jing , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , LIU, Hongying
IPC分类号： C07D403/14 , A61K31/506 , A61K31/519 , A61P11/06 , A61P17/00 , C07D403/12 , C07D239/50 , C07D417/12 , A61P29/00 , A61P37/00
CPC分类号： C07D471/04 , C07D239/50 , C07D401/12 , C07D403/12 , C07D403/14 , C07D417/12
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公开(公告)号：EP2955174B1
公开(公告)日：2019-02-27
申请号：EP13874809.0
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D307/33 , A61K31/635 , A61P31/04
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4.发明授权THIAZINE AMIDE DERIVATIVE AND PHARMACEUTICAL COMPOSITION AND USE THEREOF 有权THAZINAMIDDERIVAT SOWIE PHARMAZEUTISCHE ZUSAMMENSETZUNG UND VERWENDUNG DAVON
公开(公告)号：EP2889293B1
公开(公告)日：2017-04-26
申请号：EP12883262.3
申请日：2012-08-24
发明人： LI, Song , XIAO, Junhai , HAN, Dan , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui , JIANG, Dan , CHEN, Wei , LIU, Hongying
CPC分类号： C07D279/12
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公开(公告)号：EP2005945A9
公开(公告)日：2009-07-01
申请号：EP06775361.6
申请日：2006-08-11
发明人： LI, Song , ZHONG, Wu , XIAO, Junhai , XIE, Yunde , LI, Xingzhou , CUI, Hao , ZHENG, Zhibing
CPC分类号： A61K31/215 , A61K9/0056 , A61K9/0095 , A61K9/141 , A61K9/1623 , A61K9/1635 , A61K9/1652
摘要： The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt.% oseltamivir phosphate, 75.0-97.5 wt.% diluent, 0.1-5.0 wt.% binder, optionally 1.0-5.0 wt.% edible flavouring essence, sweetener and/or edible pigment. It is prepared by using 30-55v/v% aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficultly. The preparation of the granule is simple and low in production cost.
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公开(公告)号：EP3327010B1
公开(公告)日：2019-12-25
申请号：EP16817233.6
申请日：2016-06-28
发明人： LI, Song , XIAO, Junhai , LYU, Boqun , WANG, Hongqiang , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , ZHOU, Xinbo , LI, Xingzhou , WANG, Xiaokui
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公开(公告)号：EP3150576B1
公开(公告)日：2019-07-10
申请号：EP15800371.5
申请日：2015-05-20
发明人： LI, Song , XIAO, Junhai , WANG, Lili , LONG, Long , LI, Wei , LUO, Haoming , LI, Feifei , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui , CAO, Ruiyuan
IPC分类号： C07C251/86 , C07C249/16 , C07C255/58 , C07C253/30 , A61K31/165 , A61K31/277 , A61P7/06 , A61P7/08
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公开(公告)号：EP3444240A1
公开(公告)日：2019-02-20
申请号：EP17781872.1
申请日：2017-04-11
发明人： LI, Song , ZHOU, Xinbo , XIAO, Dian , ZHONG, Wu , XIAO, Junhai , ZHENG, Zhibing , LI, Xingzhou , XIE, Yunde , WANG, Xiaokui
IPC分类号： C07D271/12 , C07D413/12 , C07H13/04 , C07H1/00 , A61K31/4245 , A61K31/7056 , A61P25/28 , A61P25/18 , A61P25/16 , A61P25/00 , A61P11/00
摘要： Disclosed in the present invention is a compound of Formula (I), a geometric or optical isomer, a pharmaceutically acceptable salt, a solvate or a polymorph thereof. Also disclosed in the present invention is a composition comprising the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof. Also disclosed in the present invention is a use of the compound of Formula (I), the geometric or optical isomer, the pharmaceutically acceptable salt, the solvate or the polymorph thereof in the treatment of a disease or disorder such as a hypoglutamatergic condition, a neurodegenerative disease or respiratory depression, particularly in the treatment of a disease or disorder associated with AMPA receptor.
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公开(公告)号：EP2952509B1
公开(公告)日：2018-06-13
申请号：EP13874396.8
申请日：2013-12-10
发明人： LI, Song , XIAO, Junhai , ZHAO, Mingming , ZHONG, Wu , WANG, Lili , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHAO, Guoming , ZHOU, Xinbo , WANG, Xiaokui , CHEN, Wei
IPC分类号： C07D263/26 , A61K31/421 , A61P31/04
CPC分类号： C07D263/26 , A61K31/421 , A61K45/06 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478
摘要： The invention relates to a compound of formula I, and a preparation method and use thereof. The compound has a bacterial quorum-sensing regulatory effect, and can be used for prevention and/or treatment of a disease caused by a bacterial infection.
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10.发明公开PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252A1
公开(公告)日：2013-06-12
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
摘要： Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
摘要翻译： 本发明公开了哒嗪衍生物由式I或其药学上可接受的盐或它们的水合物，药物组合物包含所述化合物，和在制备药物用于治疗和/或预防与病毒感染相关的疾病或病症中使用的化合物。 由式I化合物具有抗病毒活性，尤其是爱抗病毒微小RNA活性。 符号所表示的化合物中的描述在说明书中。
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