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1.发明公开Aldehyde oxidase, process for its production and microorganism therefor 失效Aldehyd-Oxydase，Verfahren zu deren Herstellung und Mikroorganismdafür。
公开(公告)号：EP0091810A2
公开(公告)日：1983-10-19
申请号：EP83302021.7
申请日：1983-04-11
CPC分类号： C12N9/0008 , A23L11/33 , C12Q1/26 , C12R1/38 , C12Y102/03001 , Y10S435/874
摘要： A new enzyme, aldehyde oxidase, catalyses the oxidation of an aldehyde to a corresponding acid but does not have any catalytic action upon other substrates, particularly nitrogen-containing aromatic heterocyclic compounds, purine, hypoxanthine and quinine. The enzyme is produced by fermentation.
A biologically pure culture of the microorganism Pseudomonas sp. No. 6233, FERM P-6467, which produces recoverable quantities of aldehyde oxidase when cultured, is another embodiment of the present invention.摘要翻译： 新的醛醛氧化酶催化醛氧化成相应的酸，但对其它底物，特别是含氮芳族杂环化合物，尿，次黄嘌呤和奎宁没有任何催化作用。 该酶通过发酵产生。 ...生物纯培养的微生物假单胞菌属 号6233，FERM P-6467，当培养时产生可回收量的醛氧化酶，是本发明的另一个实施方案。
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公开(公告)号：EP0356934A3
公开(公告)日：1991-09-11
申请号：EP89115716.6
申请日：1989-08-25
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C12P1/00 , Y10S435/814 , Y10S435/849
摘要： The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.
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3.发明公开Process for producing neuraminidase and method and reagent for the quantitative determination of a sialic acid-containing substance using neuraminidase 失效生产神经酰胺糖苷酶的方法及使用神经酰胺酸酶定量测定含磷酸的物质的方法和试剂
公开(公告)号：EP0133694A3
公开(公告)日：1987-03-04
申请号：EP84109221
申请日：1984-08-03
发明人： Uwajima, Takayuki , Aisaka, Kazuo
CPC分类号： C12Y302/01018 , C12N9/24 , C12N9/2402 , C12Q1/34 , C12R1/29 , Y10S435/867 , Y10S435/868
摘要： Neuraminidase is produced by culturing a neuraminidase producing microorganism belonging to the genus Micromonospora. The neuraminidase is useful for the quantitative determination of a sialic acid-containing substance in a sample.
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4.发明授权
公开(公告)号：EP0010296B1
公开(公告)日：1982-12-01
申请号：EP79104011.6
申请日：1979-10-17
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公开(公告)号：EP0297533B1
公开(公告)日：1994-06-01
申请号：EP88110366.7
申请日：1988-06-29
CPC分类号： C12N9/80 , C12Q1/34 , G01N2333/948 , Y10S435/814 , Y10S435/815
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公开(公告)号：EP0173276A3
公开(公告)日：1988-08-24
申请号：EP85110679
申请日：1985-08-26
摘要： 57 The determination of a substrate or an activity of an enzyme in a sample containing ammonia by using a reaction system which forms ammonia can be performed by decomposing ammonia in the sample with an ammonia-decomposing reagent system, adding a reagent system necessary for the formation of ammonia from the substrate or the substrate for the enzyme to form ammonia and determining the formed ammonia.
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7.发明公开Process for producing neuraminidase and method and reagent for the quantitative determination of a sialic acid-containing substance using neuraminidase 失效一种用于生产神经氨酸酶和方法和试剂用于定量测定使用神经氨酸酶一含唾液酸的物质的过程。
公开(公告)号：EP0133694A2
公开(公告)日：1985-03-06
申请号：EP84109221.6
申请日：1984-08-03
发明人： Uwajima, Takayuki , Aisaka, Kazuo
CPC分类号： C12Y302/01018 , C12N9/24 , C12N9/2402 , C12Q1/34 , C12R1/29 , Y10S435/867 , Y10S435/868
摘要： Neuraminidase is produced by culturing a neuraminidase producing microorganism belonging to the genus Micromonospora. The neuraminidase is useful for the quantitative determination of a sialic acid-containing substance in a sample.
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8.发明公开
公开(公告)号：EP0091810A3
公开(公告)日：1984-01-18
申请号：EP83302021
申请日：1983-04-11
CPC分类号： C12N9/0008 , A23L11/33 , C12Q1/26 , C12R1/38 , C12Y102/03001 , Y10S435/874
摘要： A new enzyme, aldehyde oxidase, catalyses the oxidation of an aldehyde to a corresponding acid but does not have any catalytic action upon other substrates, particularly nitrogen-containing aromatic heterocyclic compounds, purine, hypoxanthine and quinine. The enzyme is produced by fermentation. A biologically pure culture of the microorganism Pseudomonas sp. No. 6233, FERM P-6467, which produces recoverable quantities of aldehyde oxidase when cultured, is another embodiment of the present invention.
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公开(公告)号：EP0356934A2
公开(公告)日：1990-03-07
申请号：EP89115716.6
申请日：1989-08-25
IPC分类号： C12P17/18
CPC分类号： C12P17/182 , C12P1/00 , Y10S435/814 , Y10S435/849
摘要： The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.
摘要翻译： 本发明涉及一种生产L（ - ） - 四氢叶酸的方法，其包括在（1）NADP或NADPH存在下使二氢叶酸还原酶作用于二氢叶酸，和（2）葡萄糖和葡萄糖脱氢酶。 L（ - ） - 四氢叶酸可用作L（ - ） - 白菜素的中间体。
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公开(公告)号：EP0297533A3
公开(公告)日：1990-01-31
申请号：EP88110366.7
申请日：1988-06-29
CPC分类号： C12N9/80 , C12Q1/34 , G01N2333/948 , Y10S435/814 , Y10S435/815
摘要： A novel acetylpolyamine amidohydrolase is described. The enzyme specifically hydrolyzes the amino bond in acetylputrescine, acetylcadaverine, acetylspermidine and acetylspermine with strong substrate affinity. The enzyme is preferably produced by culturing a microorganism belonging to the genus Mycoplana, and is used in the quantitative determination of polyamine contained in a living body sample, which is useful for cancer diagnosis.
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