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公开(公告)号：EP0092845A2
公开(公告)日：1983-11-02
申请号：EP83104077.9
申请日：1983-04-26
发明人： Katsumata, Hideo , Katsumata, Shigeo , Ishii, Shinzo , Arai, Yuko
CPC分类号： C12N9/0006 , C12N9/00 , C12N9/18 , C12N9/52 , C12N9/80 , Y10S435/815
摘要： Disclosed is a process for purifying an enzyme contained in a solution such as cell extract liquor or fermentation culture liquor. The crude enzyme solution is brought into contact with either a strongly acidic cation exchange resin of high porous type or a strongly basic anion exchange resin of high porous type to adsorb the enzyme on the resin. An eluting agent is then passed through the resin to elute out the enzyme as a purified enzyme solution.
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公开(公告)号：EP0128370A3
公开(公告)日：1985-08-07
申请号：EP84105338
申请日：1984-05-11
发明人： Hirata, Tadashi , Kobayashi, Shigeru , Takahashi, Keiichi , Morimoto, Makoto Kyowa Hakko Kogyo Seiwa Ryo , Arai, Yuko
IPC分类号： C07D471/18 , C07D498/22 , A61K31/495
CPC分类号： C07D471/18 , C07D498/22
摘要： A compound represented by the formula:
wherein R is a hydrogen atom or a lower alkyl group, X is a hydroxymethyl group and Y is a cyano group, and when R is a lower alkyl group, X and Y may combine to form -CH 2 -O-, and salts thereof, process for preparing the same, and an anti-tumor composition containing the same, which is improved in stability in comparison with a starting compound DC-52.-
公开(公告)号：EP0128370B1
公开(公告)日：1987-08-26
申请号：EP84105338.2
申请日：1984-05-11
发明人： Hirata, Tadashi , Kobayashi, Shigeru , Takahashi, Keiichi , Morimoto, Makoto Kyowa Hakko Kogyo Seiwa Ryo , Arai, Yuko
IPC分类号： C07D471/18 , C07D498/22 , A61K31/495
CPC分类号： C07D471/18 , C07D498/22
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公开(公告)号：EP0079792A2
公开(公告)日：1983-05-25
申请号：EP82306073.6
申请日：1982-11-15
发明人： Tamura, Shigeaki , Endo, Kenichi , Katsumata, Hideo , Arai, Yuko
摘要： Urease having 1 ~ 5 x 10 2 Km value is produced by culturing a microorganism of the genus Corynebactenum, Breivibacterium, Arthrobacter, Proteus, Microbacterium or Bordetella. The enzyme is useful for the determination of urea in the rate assay method.
摘要翻译： 通过培养棒状杆菌属，芽孢杆菌属，节杆菌属，蛋白质，微杆菌属或博德特氏菌属的微生物，产生具有1×5×10 -2 Km值的类似的脲酶。 该酶可用于在速率测定方法中测定尿素。
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公开(公告)号：EP0092845B1
公开(公告)日：1987-07-08
申请号：EP83104077.9
申请日：1983-04-26
发明人： Katsumata, Hideo , Katsumata, Shigeo , Ishii, Shinzo , Arai, Yuko
CPC分类号： C12N9/0006 , C12N9/00 , C12N9/18 , C12N9/52 , C12N9/80 , Y10S435/815
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公开(公告)号：EP0079792B1
公开(公告)日：1987-07-08
申请号：EP82306073.6
申请日：1982-11-15
发明人： Tamura, Shigeaki , Endo, Kenichi , Katsumata, Hideo , Arai, Yuko
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公开(公告)号：EP0079792A3
公开(公告)日：1983-11-09
申请号：EP82306073
申请日：1982-11-15
发明人： Tamura, Shigeaki , Endo, Kenichi , Katsumata, Hideo , Arai, Yuko
摘要： Urease having 1 ~ 5 x 10 2 Km value is produced by culturing a microorganism of the genus Corynebactenum, Breivibacterium, Arthrobacter, Proteus, Microbacterium or Bordetella. The enzyme is useful for the determination of urea in the rate assay method.
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8.发明公开
公开(公告)号：EP0128370A2
公开(公告)日：1984-12-19
申请号：EP84105338.2
申请日：1984-05-11
发明人： Hirata, Tadashi , Kobayashi, Shigeru , Takahashi, Keiichi , Morimoto, Makoto Kyowa Hakko Kogyo Seiwa Ryo , Arai, Yuko
IPC分类号： C07D471/18 , C07D498/22 , A61K31/495
CPC分类号： C07D471/18 , C07D498/22
摘要： A compound represented by the formula:
wherein R is a hydrogen atom or a lower alkyl group, X is a hydroxymethyl group and Y is a cyano group, and when R is a lower alkyl group, X and Y may combine to form -CH 2 -O-, and salts thereof, process for preparing the same, and an anti-tumor composition containing the same, which is improved in stability in comparison with a starting compound DC-52.-
公开(公告)号：EP0092845A3
公开(公告)日：1984-03-14
申请号：EP83104077
申请日：1983-04-26
发明人： Katsumata, Hideo , Katsumata, Shigeo , Ishii, Shinzo , Arai, Yuko
CPC分类号： C12N9/0006 , C12N9/00 , C12N9/18 , C12N9/52 , C12N9/80 , Y10S435/815
摘要： Disclosed is a process for purifying an enzyme contained in a solution such as cell extract liquor or fermentation culture liquor. The crude enzyme solution is brought into contact with either a strongly acidic cation exchange resin of high porous type or a strongly basic anion exchange resin of high porous type to adsorb the enzyme on the resin. An eluting agent is then passed through the resin to elute out the enzyme as a purified enzyme solution.
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