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公开(公告)号：EP1829965A1
公开(公告)日：2007-09-05
申请号：EP05809612.4
申请日：2005-11-25
发明人： MIZOGUCHI, Hiroshi , HARA, Kiyotaka , MORI, Hideo
IPC分类号： C12N15/09 , C12N1/20 , C12N1/21 , C12P7/64 , C12P13/00 , C12P13/04 , C12P17/00 , C12P19/00 , C12P19/30 , C12P19/38 , C12P21/02
摘要： According to the present invention, the E . coli mutant strain having chromosomal DNA that is at least 470 kbp shorter than that of a wild-type E . coli strain exhibits such a property that the number of the cells after a certain period of culture is greater than a wild-type strain. Thus, by culturing the mutant strain in a medium so as to generate and accumulate a useful substance in the culture, a useful substance such as proteins, peptides, amino acids, nucleic acids, vitamins, saccharides, organic acids, and lipids can be efficiently produced.
摘要翻译： 根据本发明，具有比野生型大肠杆菌菌株短至少470kbp的染色体DNA的大肠杆菌突变株显示出这样的性质，即培养一段时间后的细胞数目是 大于野生型菌株。 因此，通过在培养基中培养突变菌株以在培养物中产生并积累有用物质，可以有效地使蛋白质，肽，氨基酸，核酸，维生素，糖类，有机酸和脂质等有用物质 产生的。
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2.发明公开PROCESS FOR PRODUCING HMG-CoA REDUCTASE INHIBITOR 有权VERFAHREN ZUR HERSTELLUNG EINES HMG-COA REDUKTASE HEMMERS
公开(公告)号：EP1148122A1
公开(公告)日：2001-10-24
申请号：EP00901980.3
申请日：2000-01-28
CPC分类号： C12N9/0004 , C07K14/32 , C12P7/62 , C12P17/06
摘要： The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a):
wherein R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl, or an alkali metal, and R 2 represents a substituted or unsubstituted alkyl or a substituted or unsubstituted aryl,
or a ring-closed lactone form thereof;
a DNA encoding said protein; and a recombinant DNA comprising said DNA.摘要翻译： 本发明涉及一种衍生自属于芽孢杆菌属的微生物的蛋白质，其具有使由式（Ia）表示的化合物羟基化的活性：其中R 1表示氢原子，取代或未取代的 烷基或碱金属，R 2表示取代或未取代的烷基或取代或未取代的芳基或其封闭的内酯形式; 编码所述蛋白质的DNA; 和包含所述DNA的重组DNA。
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