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    COMPOSITION FOR COATING SUPPORT FOR PREPARATION OF CELL SHEET, SUPPORT FOR PREPARATION OF CELL SHEET AND PROCESS FOR PRODUCING CELL SHEET
    4.
    发明公开
    COMPOSITION FOR COATING SUPPORT FOR PREPARATION OF CELL SHEET, SUPPORT FOR PREPARATION OF CELL SHEET AND PROCESS FOR PRODUCING CELL SHEET 有权
    组合物用于涂布载体用于制备细胞层，TANK用于生产的细胞层产生的细胞层和方法

    公开(公告)号：EP1669440A1

    公开(公告)日：2006-06-14

    申请号：EP04723331.7

    申请日：2004-03-25

    申请人： Keio University

    发明人： FUKUDA, Keiichi, c/o Keio University Sch. Medicine ,  ITABASHI, Yuji, c/o Keio University Sch. Medicine ,  TSUBOTA, Kazuo

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2533/56

    摘要： Disclosed are a method for manufacturing a cell sheet, comprising culturing cells on a fibrin-coated surface of a substrate until the cells reach confluency, continuing the cultivation of the cells for a sufficient time period to cause the degradation of fibrin at the bottom of the cells, and detaching the cultured cells from the substrate surface in a sheet-like form to give a cell sheet; a substrate for cell sheet preparation, a surface of which is coated with fibrin; and a composition for use in coating with fibrin a surface of a substrate for cell sheet preparation, the composition comprising fibrinogen and thrombin. The invention enables to cell sheets to be manufactured by a simple manipulation using a substrate coated with a commercial, commonly available material of which safety has been confirmed.

    摘要翻译： 本发明公开了一种用于制造电池板，一个基片的纤维蛋白 - 包被的表面上，其包括培养细胞直至细胞达到汇合，继续细胞培养足够的时间周期在的底部，以使血纤维蛋白的降解的方法 细胞，和分离由在一个片状的表面基板上的培养的细胞，得到的细胞片; 一个基板为细胞片制剂，其涂覆有纤维蛋白的所有的表面上; 和用于涂料使用纤维蛋白一个基片的表面为细胞片制剂的组合物，所述组合物包含纤维蛋白原和凝血酶。 本发明能够通过使用涂有安全的商业广告，通常可用的材料已被证实一个基板简单的操作来制造的细胞片。

    METHOD FOR DERIVING CORNEAL ENDOTHELIUM REPLACEMENT CELLS FROM IPS CELLS
    5.
    发明公开
    METHOD FOR DERIVING CORNEAL ENDOTHELIUM REPLACEMENT CELLS FROM IPS CELLS 审中-公开

    公开(公告)号：EP3741844A1

    公开(公告)日：2020-11-25

    申请号：EP19741620.9

    申请日：2019-01-16

    申请人： Keio University

    发明人： SHIMMURA, Shigeto ,  HATOU, Shin ,  TSUBOTA, Kazuo

    IPC分类号： C12N5/0793 ,  A61K35/30 ,  A61L27/38 ,  A61P27/02 ,  C12N5/00 ,  C12N5/0735 ,  C12N5/10

    摘要： Using the medium of the present invention for inducing a cornea endothelial substitute cell from an iPS cell, the medium containing an insulin-like growth factor and a STAT3 activator, and not containing a basic fibroblast growth factor or a ROCK inhibitor, and the method of the present invention for inducing corneal endothelial substitute cells from iPS cells by using the medium, it becomes possible to efficiently produce corneal endothelial substitute cells, particularly to efficiently produce corneal endothelial substitute cells from iPS cells. Furthermore, it becomes possible to stably produce large amounts of corneal endothelial substitute cells by inducing differentiation of iPS cells into corneal endothelial substitute cells more efficiently.

    PHACOSCLEROSIS INHIBITOR
    6.
    发明公开
    PHACOSCLEROSIS INHIBITOR 审中-公开
    PHACOSCLEROSIS抑制剂

    公开(公告)号：EP3213751A1

    公开(公告)日：2017-09-06

    申请号：EP15854906.3

    申请日：2015-10-30

    申请人： Keio University

    发明人： TSUBOTA, Kazuo

    IPC分类号： A61K31/5383 ,  A61K31/198 ,  A61P27/02 ,  A61P27/12

    CPC分类号： A61K31/5383 ,  A61K9/0048 ,  A61K9/08 ,  A61K31/198 ,  A61K2300/00

    摘要： The present invention provides a crystalline lens hardening inhibitor, containing a compound represented by the formula (I):

    wherein R 1 -R 4 are the same or different and each is a hydrogen atom, a halogen atom, a hydroxy group, a sulfanyl group, a lower alkyl group, a lower acyl group, a lower alkoxy group, a carboxyl group, a carbamoyl group or a carbonylamino acid group, or a salt thereof, and/or a compound represented by the formula (II) :

    wherein R is a hydrogen atom, or a lower alkyl group optionally substituted by an amino group, a hydroxy group, a sulfanyl group or a carboxyl group, and A is a lower alkylene group, or a salt thereof.

    摘要翻译： 本发明提供一种晶状体硬化抑制剂，其含有由式（I）表示的化合物：其中R 1 -R 4相同或不同并且各自为氢原子，卤素原子，羟基，硫烷基， 低级烷基，低级酰基，低级烷氧基，羧基，氨基甲酰基或羰基氨基酸基团或其盐，和/或由式（II）表示的化合物：其中R是氢 原子或任选被氨基，羟基，硫烷基或羧基取代的低级烷基，并且A是低级亚烷基或其盐。

    METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL
    8.
    发明公开
    METHOD FOR PRODUCING CORNEAL ENDOTHELIAL CELL 有权
    VERFAHREN ZUR HERSTELLUNG VON HORNHAUTENDOTHELZELLEN

    公开(公告)号：EP2765188A1

    公开(公告)日：2014-08-13

    申请号：EP12837799.1

    申请日：2012-10-05

    申请人： Keio University

    发明人： SHIMMURA, Shigeto ,  HATOU, Shin ,  TSUBOTA, Kazuo ,  YOSHIDA, Satoru

    IPC分类号： C12N5/10 ,  A61K35/44 ,  A61L27/00 ,  A61P27/02 ,  C12N15/09

    CPC分类号： C12N5/0621 ,  A61K35/00 ,  A61L27/3808 ,  A61L27/3895 ,  A61L2430/16 ,  C12N5/069 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/235 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2501/727 ,  C12N2501/999 ,  C12N2506/08 ,  C12N2506/09 ,  C12N2506/45 ,  C12N2533/54

    摘要： The present invention aims to provide a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or iPS cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells.
    A method of inducing differentiation of stem cells into corneal endothelial cells, which includes a step of culturing the stem cells in a differentiation induction medium containing a GSK3 inhibitor (preferably a GSK3β inhibitor) and retinoic acid, preferably the differentiation induction medium further containing at least one kind selected from the group consisting of TGFb2, insulin and a ROCK inhibitor, and the like.

    摘要翻译： 本发明旨在提供一种有效地生产角膜内皮细胞，特别是角膜基质或iPS细胞来源的神经嵴干细胞的方法，通过诱导干细胞更有效的分化而大量稳定地产生角膜内皮细胞的方法 角膜内皮细胞和含有角膜内皮细胞的药物。 诱导干细胞分化为角膜内皮细胞的方法，其包括在含有GSK3抑制剂（优选GSK3 2抑制剂）和视黄酸的分化诱导培养基中培养干细胞的步骤，优选分化诱导培养基至少还含有 选自TGFb2，胰岛素和ROCK抑制剂的一种等。

    NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN
    9.
    发明公开
    NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN 审中-公开
    新的金属蛋白和方法进行生产和反对HORN预防或治疗剂或粘合皮肤疾病的这种金属蛋白

    公开(公告)号：EP2711374A1

    公开(公告)日：2014-03-26

    申请号：EP12789433.5

    申请日：2012-05-18

    申请人： Keio University ,  Kowa Company Ltd.

    发明人： HIGUCHI, Akihiro ,  INOUE, Hiroyoshi ,  TSUBOTA, Kazuo

    IPC分类号： C07K14/79 ,  C07K1/02 ,  C07K1/34 ,  A61K38/16 ,  A61P27/02

    CPC分类号： C07K14/79 ,  A61K9/0048 ,  A61K38/40

    摘要： The present invention provides: a novel metalloprotein, i.e., selenium-lactoferrin; and a process for producing the metalloprotein. Selenium-lactoferrin according to the present invention can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration.
    Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.

    摘要翻译： 本发明提供：一种新型的金属蛋白，即，硒 - 乳铁蛋白; 及其制备金属蛋白的过程。 硒 - 乳铁蛋白gemäß到本发明可以适当通过将硒盐的溶液含有乳铁蛋白和/或脱铁乳，然后对所得的混合溶液透析或超滤来制备。 硒 - 乳铁蛋白gemäß到本发明具有对角膜结膜疾病优异的治疗效果，并且是适合于在工业规模上批量生产。