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公开(公告)号：EP2591334A1
公开(公告)日：2013-05-15
申请号：EP11743635.2
申请日：2011-07-05
发明人： SCHLEIPEN, Johannes Joseph Hubertina Barbara , IMMINK, Albert Hendrik Jan , PRINS, Menno Willem Jose , KLUNDER, Derk Jan Wilfred
CPC分类号： G01N21/01 , A61B5/0059 , B01L3/508 , B01L2300/044 , B01L2300/0654 , B01L2300/0822 , B01L2300/0887 , B01L2400/043 , G01N21/552 , G01N21/648 , G01N21/7703
摘要： The invention relates to a cartridge (110) and an examination apparatus (100) for optical examinations of a sample. The cartridge (110) comprises a transparent bottom layer (113) that is of substantially uniform thickness and a top layer (111, 112) comprising a sample chamber (SC). The bottom layer and the top layer are preferably laminated onto each other, for example in a roll-to-roll process. The bottom layer (113) is provided with structures like gratings (115) that allow the incoupling or outcoupling of light.
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2.发明公开A SYSTEM FOR APPLYING MAGNETIC FORCES TO A BIOSENSOR SURFACE BY MECHANICALLY MOVING AT LEAST ONE MAGNET 审中-公开磁系统用于生物传感器和BIOSYSTEM
公开(公告)号：EP2102664A2
公开(公告)日：2009-09-23
申请号：EP07849375.6
申请日：2007-12-07
发明人： KAHLMANN, Josephus Arnoldus Henricus Maria , IMMINK, Albert Hendrik Jan , NIEUWENHUIS, Jeroen Hans , VAN DER WIJK, Thea , DE THEIJE, Femke Karina
IPC分类号： G01N35/00 , G01N33/543 , H01F7/00
CPC分类号： G01N27/745 , G01N33/54333 , G01N35/0098 , H01F7/0273
摘要： A magnetic system for biosensors or a biosystem, wherein magnetic particles that interact with molecules are brought into a magnetic field, in order to be influenced via magnetic attraction or repulsion forces. The external magnetic field is varied by mechanically moving the magnetic poles of at least one magnetic relative to the sensor or at least its surface to allow the magnetic force to be switched between effective attraction towards the sensor surface and effective repulsion away from the sensor surface.
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公开(公告)号：EP1926994A1
公开(公告)日：2008-06-04
申请号：EP06795938.7
申请日：2006-09-07
发明人： KAHLMANN, Josephus Arnoldus Henricus , DE BOER, Bart Michiel , IMMINK, Albert Hendrik Jan , NIEUWENHUIS, Jeroen
IPC分类号： G01N33/543 , G01N27/72
CPC分类号： G01N33/54326 , G01N27/745
摘要： The invention relates to a microsensor device like a magnetic biosensor (100). The microsensor device comprises an array of probe-sensors (10.1, 10.2, 10.3) for the measurement of a physical quantity, for example the concentration of molecules labeled with magnetic beads in a sample chamber. The array further comprises a reference-sensor ( 10.4) that is disposed close to the probe-sensors (10.1, 10.2, 10.3) but shielded from the physical quantity to be measured. The measuring signal of the reference-sensor (10.4) reflects the influence of environmental conditions like temperature and can therefore be used to correct the measuring signals of the probe-sensors (10.1, 10.2, 10.3). The sensors (10.1, 10.2, 10.3, 10.4) are connected via a multiplexer to the same detector unit for further processing in order to minimize variations and to reduce hardware complexity.
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公开(公告)号：EP1999452A2
公开(公告)日：2008-12-10
申请号：EP07713208.2
申请日：2007-03-06
发明人： KAHLMAN, Josephus Arnoldus Henricus Maria , IMMINK, Albert Hendrik Jan , DURIC, Haris , VAN TUIJL, Adrianus Johannes Maria , CANTATORE, Eugenio , BERGVELD, Hendrik Johannes
IPC分类号： G01N15/06 , G01N33/543 , G01N35/00 , G01R33/09 , G01R33/12
CPC分类号： G01N33/54333 , B82Y25/00 , G01N27/745 , G01N2446/00 , G01R33/09 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to a magnetic sensor device comprising excitation wires (11, 13) for generating a magnetic excitation field and a magnetic sensor element, particularly a GMR sensor (12), for sensing magnetic fields generated by labeling particles in reaction to the excitation field. The magnetic excitation fields are generated with non-sinusoidal forms, particularly as square-waves, such that their spectral range comprises a plurality of frequency components. Magnetic particles with different magnetic response characteristics can then be differentiated according to their reactions to the different frequency components of the excitation fields. The magnetic excitation field and the sensing current driving the GMR sensor (12) are preferably generated with the help of ring modulators (22, 24). Moreover, ring modulators (27, 29) may be used for the demodulation of the sensor signal.
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公开(公告)号：EP1971845A1
公开(公告)日：2008-09-24
申请号：EP06809701.3
申请日：2006-10-25
发明人： JOHNSON, Mark Thomas , IMMINK, Albert Hendrik Jan , PONJEE, Marc Wilhelmus Gijsbert , REIJME, Mirielle Ann , KAHLMAN, Josephus Arnoldus Henricus Maria , NIEUWENHUIS, Jeroen Hans , DE BOER, Bart Michiel
IPC分类号： G01N15/06 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2400/0415 , B01L2400/043 , G01N27/745 , G01N33/5438
摘要： The invention relates to a microelectronic device (200), particularly a magnetic biosensor, comprising B/E-electrodes (21) that can generate a magnetic field (B) in a sample chamber (10). The device further comprises E-electrodes (23, 24) that can generate an electrical field (E) in the sample chamber (10) in cooperation with the B/E-electrodes (21). Thus the B/E-electrodes are used for two purposes. Electrical fields (E) in the sample chamber (10) may particularly be used for pumping and/or mixing of a fluid sample or for a stringency test of particle bindings.
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公开(公告)号：EP1581934A2
公开(公告)日：2005-10-05
申请号：EP03813960.6
申请日：2003-12-17
发明人： DE BOER, Bart Michiel,c/o Société Civile SPID , VAN DEN HOMBERG, Johannes Aldegonda Theodora Maria , IMMINK, Albert Hendrik Jan , VAN ROMPAEY, Bart,c/o Société Civile SPID , TER MEULEN, Jan Matthijs,c/o Société Civile SPID
IPC分类号： G11B7/00
CPC分类号： G11B7/0062 , G11B7/126 , G11B2220/2591
摘要： The invention relates to an information recording apparatus intended to record information on an optical medium by forming series of recorded marks whose length between leading edge and trailing edge corresponds to a binary value by irradiation means with a beam of light. According to the invention, said irradiation means are sequentially pulsed to at least a high laser current write level from a low laser current level LL close to zero during the writing of a recorded mark.The invention enables to lower the average laser current during writing and also erasing. As a consequence the power dissipation is lowered.Application: Information recording apparatus, especially for SFFO, BluRay standards.
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公开(公告)号：EP2480332A2
公开(公告)日：2012-08-01
申请号：EP10763017.0
申请日：2010-09-09
CPC分类号： B01L3/502715 , A61B10/0045 , A61B10/0051 , A61B10/0096 , B01L3/5029 , B01L2200/022 , B01L2200/025 , B01L2200/027
摘要： Disclosed is a disposable cartridge (10) for insertion into a sample analyzer (50), the disposable cartridge comprising a housing (16) including a sample analysis unit (18) for engaging with the sample analyzer and a sample extraction unit (14) for extracting a sample from a sample collection unit (12) and transferring said sample to the sample analysis unit, the sample extraction unit being coupled to the sample analysis unit by a flexible connection (30), wherein one of the sample analysis unit and the sample extraction unit is flexibly connected to the housing. A sample analyzer (50) for receiving such a disposable cartridge (10) is also disclosed.
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公开(公告)号：EP2122341A1
公开(公告)日：2009-11-25
申请号：EP08719517.8
申请日：2008-02-29
发明人： VAN LANKVELT, Petrus Johannes Wilhelmus , PRINS, Menno Willem Jose , IMMINK, Albert Hendrik Jan
CPC分类号： G01N27/745 , B82Y25/00 , G01R33/0213 , G01R33/093 , G01R33/12 , G01R33/1269
摘要： The invention relates to an electromagnetic system for biosensors, in which the system can switch quickly between high magnetic gradients, without the need of movement of mechanical elements. This is realized by two independent electromagnetic units (1,1' 2, 2') which are separated in the region of the pole shoes over a gap, in which a sample volume is arranged by a cartridge (3), and in which the sensor surfaces of the biosensor are located at one or more inner surfaces of the cartridge (3).
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公开(公告)号：EP2115468B1
公开(公告)日：2010-06-16
申请号：EP07805038.2
申请日：2007-06-25
发明人： VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
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公开(公告)号：EP2115468A1
公开(公告)日：2009-11-11
申请号：EP07805038.2
申请日：2007-06-25
发明人： VAN LANKVELT, Petrus Johannes Wilhelmus , NIEUWENHUIS, Jeroen Hans , IMMINK, Albert Hendrik Jan , KAHLMAN, Josephus Arnoldus Henricus Maria
IPC分类号： G01N33/543 , G01R33/06
CPC分类号： G01N33/54373 , B82Y25/00 , G01N27/745 , G01N33/54326 , G01R33/07 , G01R33/093 , G01R33/12 , G01R33/1269 , G01R33/1276
摘要： A sensor device (50) for sensing magnetic particles (15), the sensor device (50) comprising a substrate (25) and a sensing unit (11, 20) provided on and/or in and/or near the substrate (25) and being adapted for sensing a detection signal indicative of the presence of the magnetic particles (15), and a magnetic field control unit (30 to 34) provided off the substrate (25) and being adapted for generating a time-dependent magnetic field for interaction with the magnetic particles (15).
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