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公开(公告)号：EP2532643A1
公开(公告)日：2012-12-12
申请号：EP12171202.0
申请日：2008-06-09
申请人： MannKind Corporation
发明人： Patterson, John Bruce , Lonergan, David Gregory , Flynn, Gary A. , Zeng, Qingping , Pallai, Peter V.
IPC分类号： C07C47/54 , C07C47/548 , C07D213/24 , C07D215/12 , C07D217/14 , C07D295/00 , C07D333/10 , C07D275/03 , A61K31/33 , C07C47/55 , C07C47/565 , C07C47/575 , C07D213/48 , C07D213/69 , C07D213/74 , C07D217/02 , C07D217/16 , C07D213/12 , C07D239/54
CPC分类号： C07C65/21 , A61K31/11 , A61K31/135 , A61K31/166 , A61K31/192 , A61K31/357 , A61K31/381 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C47/55 , C07C47/565 , C07C47/575 , C07C65/11 , C07C65/26 , C07C65/30 , C07C205/44 , C07C205/61 , C07C223/02 , C07C233/65 , C07C235/42 , C07C235/84 , C07C251/24 , C07C317/24 , C07C321/04 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/48 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D217/16 , C07D231/12 , C07D235/08 , C07D239/26 , C07D239/54 , C07D241/18 , C07D249/18 , C07D261/08 , C07D277/34 , C07D295/125 , C07D295/15 , C07D295/192 , C07D307/80 , C07D317/54 , C07D319/08 , C07D319/18 , C07D321/10 , C07D333/22 , C07D333/58 , C07D401/12 , C07D403/12 , C07D417/10 , Y02A50/389 , Y02A50/393
摘要： Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1α activity are provided.
摘要翻译： 提供了治疗与未折叠蛋白质应答有关的疾病的方法和抑制IRE-1α活性的方法。
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公开(公告)号：EP2520561B1
公开(公告)日：2016-02-10
申请号：EP12171206.1
申请日：2008-06-09
申请人： MannKind Corporation
发明人： Patterson, John Bruce , Lonergan, David Gregory , Flynn, Gary A. , Zeng, Qingping , Pallai, Peter V.
IPC分类号： C07C47/575 , C07D217/16 , C07D231/12 , C07D239/54 , C07D261/08 , C07D277/34 , C07D307/80 , C07D317/54 , C07D319/18 , C07D321/10 , C07D333/58 , C07D417/10 , C07D295/192 , A61K31/33 , C07C47/548 , C07D215/12 , C07D295/00 , C07D333/10 , C07D275/03
CPC分类号： C07C65/21 , A61K31/11 , A61K31/135 , A61K31/166 , A61K31/192 , A61K31/357 , A61K31/381 , A61K31/505 , A61K31/5375 , A61K31/5377 , C07C47/55 , C07C47/565 , C07C47/575 , C07C65/11 , C07C65/26 , C07C65/30 , C07C205/44 , C07C205/61 , C07C223/02 , C07C233/65 , C07C235/42 , C07C235/84 , C07C251/24 , C07C317/24 , C07C321/04 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/48 , C07D213/64 , C07D213/69 , C07D213/74 , C07D215/14 , C07D217/16 , C07D231/12 , C07D235/08 , C07D239/26 , C07D239/54 , C07D241/18 , C07D249/18 , C07D261/08 , C07D277/34 , C07D295/125 , C07D295/15 , C07D295/192 , C07D307/80 , C07D317/54 , C07D319/08 , C07D319/18 , C07D321/10 , C07D333/22 , C07D333/58 , C07D401/12 , C07D403/12 , C07D417/10 , Y02A50/389 , Y02A50/393
摘要： Methods of treating disorders associated with unfolded protein response and methods of inhibiting IRE-1± activity are provided.
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