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1.发明公开MICROBIAL ENGINEERING FOR THE PRODUCTION OF CHEMICAL AND PHARMACEUTICAL PRODUCTS FROM THE ISOPRENOID PATHWAY 审中-公开微生物工程FOR化学从异戊二烯信号生产和医药产品
公开(公告)号：EP2499257A1
公开(公告)日：2012-09-19
申请号：EP10779184.0
申请日：2010-11-10
IPC分类号： C12P23/00
摘要： The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGGPS) enzyme in cells and the production of terpenoids.
摘要翻译： 本发明涉及一个紫杉二烯合酶和在细胞中的香叶基香叶基二磷酸合酶（GGGPS）酶和生产萜类的的重组表达。
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公开(公告)号：EP2768954A1
公开(公告)日：2014-08-27
申请号：EP12840947.1
申请日：2012-10-19
CPC分类号： C12P7/649 , C12N1/16 , C12N9/0083 , C12N9/0097 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815 , C12P7/64 , C12P7/6463 , C12Y114/19001 , C12Y203/03008 , C12Y604/01002
摘要： Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
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3.发明公开MICROBIAL ENGINEERING FOR THE PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES 审中-公开MIKROBIELLES工程师FÜRDIE HERSTELLUNG VONFETTSÄURENUNDFETTSÄUREDERIVATEN
公开(公告)号：EP2542671A2
公开(公告)日：2013-01-09
申请号：EP11713397.5
申请日：2011-03-02
CPC分类号： C12P7/6409 , C12N9/001 , C12N9/0071 , C12N15/815 , C12P7/6463
摘要： Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
摘要翻译： 本发明的一些方面涉及使用工程微生物将碳源转化为生物燃料或生物燃料前体的方法。 本发明的一些方面涉及在微生物中发现脂质代谢的关键调节剂。 本发明的一些方面涉及用于生物燃料或生物燃料前体生产的工程微生物。
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公开(公告)号：EP1981992A2
公开(公告)日：2008-10-22
申请号：EP07717692.3
申请日：2007-01-03
CPC分类号： C12N15/81
摘要： The present invention relates to expression vectors, wherein each vector comprises at least one gene of interest and a promoter operatively linked thereto wherein each promoter comprises a nucleic acid, whose sequence is randomly mutated with respect to that of the wild-type promoter and cells comprising the same. Methods utilizing either the vectors or cells of this invention, in optimizing regulation of gene expression, protein expression, or optimized gene or protein delivery are described.
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公开(公告)号：EP3388516A1
公开(公告)日：2018-10-17
申请号：EP18161442.1
申请日：2012-10-19
CPC分类号： C12P7/649 , C12N1/16 , C12N9/0083 , C12N9/0097 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815 , C12P7/64 , C12P7/6463 , C12Y114/19001 , C12Y203/03008 , C12Y604/01002
摘要： Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
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6.发明授权
公开(公告)号：EP2645847B1
公开(公告)日：2018-01-17
申请号：EP11793960.3
申请日：2011-11-29
CPC分类号： C12N15/8243 , A01H5/00 , A01H13/00 , A23L2/60 , A23L27/36 , C12N9/0042 , C12N9/0073 , C12N9/0085 , C12N9/1085 , C12N9/1288 , C12N9/88 , C12N9/90 , C12N15/70 , C12P7/42 , C12P15/00 , C12P17/02 , C12Y106/02004 , C12Y114/13 , C12Y114/13076 , C12Y114/13078 , C12Y114/99009 , C12Y205/01029 , C12Y402/03019 , C12Y505/01012 , C12Y505/01013 , Y02P20/52
摘要： The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides.
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7.发明公开MICROBIAL PRODUCTION OF NATURAL SWEETENERS, DITERPENOID STEVIOL GLYCOSIDES 有权ITE EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN EN
公开(公告)号：EP2645847A1
公开(公告)日：2013-10-09
申请号：EP11793960.3
申请日：2011-11-29
CPC分类号： C12N15/8243 , A01H5/00 , A01H13/00 , A23L2/60 , A23L27/36 , C12N9/0042 , C12N9/0073 , C12N9/0085 , C12N9/1085 , C12N9/1288 , C12N9/88 , C12N9/90 , C12N15/70 , C12P7/42 , C12P15/00 , C12P17/02 , C12Y106/02004 , C12Y114/13 , C12Y114/13076 , C12Y114/13078 , C12Y114/99009 , C12Y205/01029 , C12Y402/03019 , C12Y505/01012 , C12Y505/01013 , Y02P20/52
摘要： The invention relates to recombinant expression of a steviol or steviol glycosides biosynthetic pathway enzymes in cells and the production of steviol or steviol glycosides.
摘要翻译： 本发明涉及细胞中甜菊醇或甜菊糖苷生物合成途径酶的重组表达以及甜菊醇或甜菊糖苷的生产。
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公开(公告)号：EP2768954B1
公开(公告)日：2018-12-05
申请号：EP12840947.1
申请日：2012-10-19
CPC分类号： C12P7/649 , C12N1/16 , C12N9/0083 , C12N9/0097 , C12N9/1025 , C12N9/1029 , C12N9/88 , C12N9/93 , C12N15/815 , C12P7/64 , C12P7/6463 , C12Y114/19001 , C12Y203/03008 , C12Y604/01002
摘要： Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments, microbes are provided that are engineered to modulate a combination of rate-controlling steps of lipid synthesis, for example, a combination of a step generating metabolites, acetyl-CoA, ATP or NADPH for lipid synthesis (a push step), and a step sequestering a product or an intermediate of a lipid synthesis pathway that mediates feedback inhibition of lipid synthesis (a pull step). Such push-and-pull engineered microbes exhibit greatly enhanced conversion yields and TAG synthesis and storage properties.
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9.发明公开MICROBIAL ENGINEERING FOR THE PRODUCTION OF FATTY ACIDS AND FATTY ACID DERIVATIVES 审中-公开生产脂肪酸和脂肪酸衍生物的微生物工程
公开(公告)号：EP3312271A1
公开(公告)日：2018-04-25
申请号：EP17193531.5
申请日：2011-03-02
CPC分类号： C12P7/6409 , C12N9/001 , C12N9/0071 , C12N15/815 , C12P7/6463
摘要： Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
摘要翻译： 本发明的一些方面涉及可用于使用工程微生物将碳源转化成生物燃料或生物燃料前体的方法。 本发明的一些方面涉及微生物中脂质代谢的关键调节剂的发现。 本发明的一些方面涉及用于生物燃料或生物燃料前体生产的工程微生物。
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公开(公告)号：EP2307560A2
公开(公告)日：2011-04-13
申请号：EP09770562.8
申请日：2009-06-26
CPC分类号： B01L3/502715 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/087 , B01L2400/0421
摘要： The present invention relates generally to the use of droplets to culture and/or assay cells or other species. In some cases, the cells or other species may be sorted based upon the results of the culture and/or assay. In some embodiments, cells other species can be encapsulated in droplets and exposed to one or more agents (e.g., a sugar, an indicator dye, etc.). For instance, in some cases, exposure of cells to the agents may result in the production of metabolites or other compounds (e.g., amino acids, proteins, organic acids, etc.) which may be, for example, assayed or otherwise determined. In some embodiments, the reaction of an agent with cells and/or other species within a droplet may reveal a property of the cells or other species (e.g., sugar consumption, growth rate, ability to withstand exposure to the agent, etc.). As an example, cells that produce desired metabolites or exhibit certain properties may be separated from the other cells via sorting techniques. Other aspects of the invention relate to devices or kits for implementing such sorts, methods of promoting such techniques, or the like.
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