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公开(公告)号：EP1060175B1
公开(公告)日：2004-11-17
申请号：EP99910192.6
申请日：1999-02-04
发明人： BODE, Wolfram , MORODER, Luis , PEREIRA, Pedro, Jose, Barbosa , BERGNER, Andreas , HUBER, Robert , SOMMERHOFF, Christian , SCHASCHKE, Norbert , BÄR, Thomas , MARTIN, Thomas , STADLWIESER, Josef , ULRICH, Wolf-Rüdiger , DOMINIK, Andreas , THIBAUT, Ulrich , BUNDSCHUH, Daniela , BEUME, Rolf , GOEBEL, Karl-Josef
IPC分类号： C07D401/12 , C07D295/192 , A61K31/44
CPC分类号： C07D213/81 , C07C279/16 , C07D211/58 , C07D213/82 , C07D295/185 , C07D295/215 , C07D401/14
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公开(公告)号：EP1267854B1
公开(公告)日：2007-11-21
申请号：EP01938022.9
申请日：2001-03-15
发明人： MAGDOLEN, Viktor , SPERL, Stefan , STÜRZEBECHER, Jörg , WILHELM, Olaf , ARROYO-DEPRADA, Nuria , MORODER, Luis , HUBER, Robert , JACOB, Uwe , BODE, Wolfram
IPC分类号： A61K31/00
CPC分类号： C07C279/18 , A61K31/155 , C07C2603/74
摘要： The invention relates to novel selective inhibitors of the urokinase plasminogen activator (uPA, EC 3.4.21.31), of the arylguanidine type.
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公开(公告)号：EP1446139A2
公开(公告)日：2004-08-18
申请号：EP02803402.3
申请日：2002-11-21
发明人： HUBER, Robert , SONDERMANN, Peter , JACOB, Uwe
IPC分类号： A61K38/00
CPC分类号： A61K38/1774
摘要： The invention relates to pharmaceutical compositions containing one of the receptors FcyR llb or FcyR III in a recombinant-produced, soluble form, and to the use of the same for the treatment of diseases or conditions which are caused by exuberant immunoreactions and the pathologically increased formation of antibodies, especially auto-antibodies. Said pharmaceutical compositions are especially useful in the fields of multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
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公开(公告)号：EP1135486B1
公开(公告)日：2005-09-28
申请号：EP99961054.6
申请日：1999-12-03
发明人： SONDERMANN, Peter , HUBER, Robert , JAKOB, Uwe
IPC分类号： C12N15/12 , C07K14/705 , C12N1/21 , C12N15/70 , G01N33/53 , G01N33/68 , A61K38/17 , C07K17/00
CPC分类号： C07K14/70535 , A61K38/00 , C07K2299/00
摘要： Recombinant soluble Fc receptors according to the present invention are characterized by the absence of transmembrane domains, signal peptides and glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to a very homogenous and pure product. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modelling of artificial molecules. A further embodiment comprises coupling the Fc receptors according to the invention to solid materials like chromatography materials that can be used to separate and/or enrich antibodies.
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5.发明公开CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
公开(公告)号：EP1390488A2
公开(公告)日：2004-02-25
申请号：EP02748701.6
申请日：2002-05-13
发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan
CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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6.发明授权
公开(公告)号：EP1709073B1
公开(公告)日：2011-08-10
申请号：EP04798098.2
申请日：2004-11-26
发明人： HUBER, Robert , SONDERMANN, Peter , JACOB, Uwe , WENDT, Kerstin , CHIARA, Cabrele , MORODER, Luis
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcϜRllb or FcϜRlla.
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7.发明公开IMPROVED IMMUNOASSAY INVOLVING MUTANT ANTIGENS TO REDUCE UNSPECIFIC BINDING 审中-公开改善的免疫试验程序突变体抗原综合非特异性结合，以减少
公开(公告)号：EP2064554A2
公开(公告)日：2009-06-03
申请号：EP07786045.0
申请日：2007-07-12
发明人： JACOB, Uwe , BREITHAUPT, Constanze , HUBER, Robert
CPC分类号： G01N33/6896 , G01N33/6854 , G01N2333/70503 , G01N2800/285
摘要： The present invention concerns in general the field of antigen-antibody-interaction-based analysis-methods and kits therefore. In particular, the present invention concerns a method for a quantitative in vitro analysis to diagnose, to categorise, to predict and/or to monitor the progression of a condition comprising contacting a sample suspected of containing anti-A-antibodies from a subject to be analysed with native and mutant antigen A, wherein the binding to mutant antigen A helps to eliminate unspecific binding to antigen A and furthermore helps to eliminate individual patient based artefacts, so that clear and unbiased data for the formation of complexes of anti-A-antibodies and antigen A are obtained. The present invention also relates to a kit for carrying out such a method. For example, the antigen is the MOG protein, and it is used as a marker for Multiple Sclerosis.
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8.发明授权
公开(公告)号：EP1446139B1
公开(公告)日：2008-09-24
申请号：EP02803402.3
申请日：2002-11-21
发明人： HUBER, Robert , SONDERMANN, Peter , JACOB, Uwe
CPC分类号： A61K38/1774
摘要： The invention relates to pharmaceutical compositions containing one of the receptors FcyR llb or FcyR III in a recombinant-produced, soluble form, and to the use of the same for the treatment of diseases or conditions which are caused by exuberant immunoreactions and the pathologically increased formation of antibodies, especially auto-antibodies. Said pharmaceutical compositions are especially useful in the fields of multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
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9.发明授权CRYSTAL STRUCTURE OF 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE 有权2-C-甲基-D-赤藓醇2,4-环二合酶的晶体结构
公开(公告)号：EP1390488B1
公开(公告)日：2007-08-29
申请号：EP02748701.6
申请日：2002-05-13
发明人： BACHER, Adelbert , HECHT, Stefan , HUBER, Robert , KAISER, Johannes , ROHDICH, Felix , STEINBACHER, Stefan
CPC分类号： C12Y406/01012 , C07K2299/00 , C12N9/88
摘要： This invention discloses the crystal structure of 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase and crystal structures of said synthase with 4-diphosphocytidyl-2C-methyl-D-erythritol, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate, cytidine monophosphate, cytidine diphosphate, cytidine and a combination of cytidine monophosphate and 2C-methyl-D-erythritol 2,4-cyclodiphosphate; with or without zinc. Further, computer-aided methods of identifying inhibitors of said synthase and inhibitors are provided.
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10.发明公开
公开(公告)号：EP1709073A2
公开(公告)日：2006-10-11
申请号：EP04798098.2
申请日：2004-11-26
发明人： HUBER, Robert , SONDERMANN, Peter , JACOB, Uwe , WENDT, Kerstin , CHIARA, Cabrele , MORODER, Luis
IPC分类号： C07K14/705 , C07K16/28 , C12N15/12 , C12N15/63 , A61K38/17 , A61K39/00 , G01N33/53 , G01N33/68
CPC分类号： C07K14/70535 , A61K2039/505 , C07K16/283 , C07K2317/34
摘要： The invention relates to novel immunogens carrying conformationally discriminating epitopes (CDEs) and to immunization methods for producing antibodies that specifically recognize proteins with very closely related homologues. In particular, the invention relates to antibodies which are specific for either FcϜRllb or FcϜRlla.
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