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公开(公告)号：EP1461026A2
公开(公告)日：2004-09-29
申请号：EP02784630.2
申请日：2002-11-27
发明人： OGIDIGBEN, Miller, J. , YOUNG, Robert, N. , METTERS, Kathleen, M. , SLIPETZ, Deborah, M. , BILLOT, Xavier
IPC分类号： A61K31/16 , A61K31/40 , A61K31/41 , A61K31/215
CPC分类号： A61K45/06 , A61K9/0048 , A61K31/4015 , A61K31/557 , A61K31/5575 , A61K31/559 , A61K2300/00
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions that are related to elevated intraocular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.
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公开(公告)号：EP1148877A1
公开(公告)日：2001-10-31
申请号：EP99970321.8
申请日：1999-10-12
发明人： HARADA, Shun-Ichi , MACHWATE, Mohamed , RODAN, Gideon, A. , LABELLE, Marc , METTERS, Kathleen , YOUNG, Robert, N.
IPC分类号： A61K31/41 , A61K31/66 , A61K31/415 , A61K31/675
CPC分类号： G01N33/88 , A61K31/00 , A61K31/4196 , A61K31/66 , A61K45/06 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： The present invention relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype antagonist.
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公开(公告)号：EP1558602A2
公开(公告)日：2005-08-03
申请号：EP03809227.6
申请日：2003-10-23
发明人： BILLOT, Xavier , BEUNARD, Jean-Luc , HAN, Yongxin , YOUNG, Robert, N. , COLUCCI, John , GIRARD, Mario , WILSON, Marie-Claire
IPC分类号： C07D403/06
CPC分类号： C07D403/06
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of Formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
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4.发明公开COMPOSITIONS FOR TREATING INFLAMMATION CONTAINING CERTAIN PROSTAGLANDINS AND A SELECTIVE CYCLOOXYGENASE-2 INHIBITOR 失效组合物治疗炎症，某些前列腺素和环氧合酶-2抑制剂含
公开(公告)号：EP0853481A1
公开(公告)日：1998-07-22
申请号：EP96930930.0
申请日：1996-09-24
CPC分类号： A61K45/06 , A61K31/557 , A61K31/34 , A61K31/19 , A61K2300/00
摘要： A method of treating cyclooxygenase mediated disease while promoting the healing of certain lesions including gastric ulcers comprising the co-administration of certain prostaglandins and a selective cyclooxygenase-2 inhibitor, or the co-administration of an anti-ulcer agent and a selective cyclooxygenase-2 inhibitor as defined herein.
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公开(公告)号：EP0737196A1
公开(公告)日：1996-10-16
申请号：EP95904990.0
申请日：1994-12-22
发明人： YOUNG, Robert, N. , LABELLE, Marc , LEBLANC, Yves , LAU, Cheuk, K. , DUFRESNE, Claude , GAREAU, Yves , XIANG, Yi, Bin
CPC分类号： C07D491/04 , C07D495/04 , C07D513/04
摘要： Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.
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6.发明公开1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA 有权1.5二取代吡咯-2-酮衍生物FOR USE AS EP4受体激动剂等眼疾病治疗AS 青光眼
公开(公告)号：EP1513589A1
公开(公告)日：2005-03-16
申请号：EP03727099.8
申请日：2003-06-02
发明人： BILLOT, Xavier , YOUNG, Robert, N. , HAN, Yongxin
IPC分类号： A61P27/06 , A61K31/4015 , A61K31/41 , C07D403/12
CPC分类号： A61K31/41 , A61K31/4015 , A61K45/06 , C07D403/12 , A61K2300/00
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors of formula (I), their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of the patient.
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公开(公告)号：EP1021429A1
公开(公告)日：2000-07-26
申请号：EP98947246.9
申请日：1998-10-01
发明人： PERRIER, Helene , HAN, Yongxin , BAYLY, Christopher , MacDONALD, Dwight , GIROUX, Andre , YOUNG, Robert, N.
IPC分类号： C07D307/42 , A61K31/34 , C07D307/38 , C07D307/46 , C07D307/54 , C07D307/56 , C07D307/64 , C07D307/66 , C07D473/38 , C07D405/04 , C07D405/12 , C07D417/12 , C07D413/12 , C07D405/06 , C07F7/08
CPC分类号： C07D307/42 , C07D307/46 , C07D307/54 , C07D405/04 , C07D405/12 , C07D413/12 , C07D417/12 , C07F7/0814
摘要： The invention encompasses the novel compound of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'-monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).
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公开(公告)号：EP1121133A1
公开(公告)日：2001-08-08
申请号：EP99951948.1
申请日：1999-10-12
发明人： HARADA, Shun-Ichi , MACHWATE, Mohamed , RODAN, Gideon, A. , WEINREB, Miron , LABELLE, Marc , METTERS, Kathleen , YOUNG, Robert, N.
CPC分类号： A61K31/663 , A61K31/00 , A61K31/192 , A61K31/20 , A61K31/557 , A61K31/5575 , A61K45/06 , G01N33/88 , A61K2300/00
摘要： The present invention relates to methods for stimulating bone formation in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of an EP4 receptor subtype agonist.
摘要翻译： 本发明涉及用于刺激哺乳动物骨形成的方法，包括向有需要的哺乳动物施用治疗有效量的EP> 4受体亚型激动剂。
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公开(公告)号：EP1453503A2
公开(公告)日：2004-09-08
申请号：EP02784629.4
申请日：2002-11-27
发明人： OGIDIGBEN, Miller, J. , YOUNG, Robert, N. , BILLOT, Xavier , METTERS, Kathleen, M. , SLIPETZ, Deborah, M.
IPC分类号： A61K31/4015
CPC分类号： C07D403/12
摘要： This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.
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