-
1.发明公开2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开-2'-甲基 - 核苷取代和方法中使用的病毒疾病治疗
公开(公告)号：EP2909221A1
公开(公告)日：2015-08-26
申请号：EP13818854.5
申请日：2013-10-15
发明人： GIRIJAVALLABHAN, Vinay , BOGEN, Stephane , TRUONG, Quang, T. , CHEN, Ping , KEREKES, Angela , BENNETT, Frank , ESPOSITE, Sara , HONG, Qingmei , DAVIES, Ian
IPC分类号： C07H19/067 , C07H19/073 , C07H19/10 , A61K31/7068 , A61K31/7072 , A61P31/14 , C07H19/06
CPC分类号： C07H19/06 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/067 , C07H19/073 , C07H19/10
摘要： The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R
1 , R
2 and R
3 , are as defined herein. The present invention also relates to compositions comprising at least one 2'-Methyl Substituted Nucleoside Derivative, and methods of using the 2'-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.-
2.发明授权2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权2'-氰基取代的核苷衍生物及其用于治疗病毒疾病的方法
公开(公告)号：EP2696679B1
公开(公告)日：2017-08-02
申请号：EP12770821.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , KEREKES, Angela , BENNETT, Frank , HUANG, Ying , NAIR, Latha , PISSARNITZKI, Dimitri , VERMA, Vishal , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA, Joseph, P.
IPC分类号： C07H19/10 , C07H19/20 , A61K31/7056 , A61K31/7068 , A61P31/12
CPC分类号： C07H19/16 , A61K31/7056 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/20 , C07H19/207 , C07H19/213 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395
摘要： The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-氰基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-氰基取代的核苷衍生物的组合物，以及使用2'-氰基取代的核苷衍生物治疗或预防患者HCV感染的方法。
-
公开(公告)号：EP3169672A1
公开(公告)日：2017-05-24
申请号：EP15821391.8
申请日：2015-07-09
发明人： PASTERNAK, Alexander , DAVIES, Ian , DING, Fa-Xiang , JIANG, Jinlong , DONG, Shuzhi , GU, Xin , SUZUKI, Takao , VACCA, Joseph P. , PU, Zhifa , XU, Shouning
IPC分类号： C07D401/00
CPC分类号： C07D519/00 , A61K31/435 , A61K31/4375 , A61K31/4745 , A61K45/06
摘要： The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
摘要翻译： 本发明提供了式（I）化合物及其药学上可接受的盐，它们是ROMK（Kir1.1）通道的抑制剂。 这些化合物可以用作利尿剂和/或利尿钠剂，并用于治疗和预防医学病症，包括心血管疾病如高血压，心力衰竭和慢性肾病以及与过量的盐和水潴留有关的病症。
-
4.发明公开2'-AZIDO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 审中-公开2'-叠氮取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2697242A1
公开(公告)日：2014-02-19
申请号：EP12771707.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , BENNETT, Frank , VERMA, Vishal , ARASAPPAN, Ashok , CHEN, Kevin , HUANG, Ying , KEREKES, Angela , NAIR, Latha , PISSARNITSKI, Dmitri , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA, Joseph, P.
IPC分类号： C07H21/02
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
-
5.发明公开2'-DISUBSTITUTED SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES 审中-公开2'-核苷二取代AND METHOD FOR其用于病毒病的治疗
公开(公告)号：EP2909210A1
公开(公告)日：2015-08-26
申请号：EP13847502.5
申请日：2013-10-11
IPC分类号： C07D487/04 , A61K31/5025 , A61P31/12
CPC分类号： A61K31/706 , A61K31/7056 , A61K38/21 , A61K45/06 , C07D487/04 , C07H7/06 , A61K2300/00
摘要： 2'-disubstituted substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof are disclosed:(1), wherein A is N
3 or NH
2 and X, Y, R
1 , R
2 , R
3 , R
4 ,R
5 and R
18 are as defined herein. Compositions comprising at least one 2'-disubstituted nucleoside derivative, and methods of using the 2'-disubstituted nucleoside derivatives for treating or preventing HCV infection in a patient are disclosed.-
6.发明授权CYCLIC PHOSPHONATE SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权环磷酸酯取代的核苷衍生物及其用于治疗病毒疾病的方法
公开(公告)号：EP3010512B1
公开(公告)日：2017-12-27
申请号：EP14814201.1
申请日：2014-06-16
发明人： BOGEN, Stephane , GIRIJAVALLABHAN, Vinay , TRUONG, Quang , CHEN, Ping , BENNETT, Frank , KEREKES, Angela , DANG, Qun , OLSEN, David, B. , DAVIES, Ian
IPC分类号： C07H19/10 , C07H19/11 , A61K31/66 , A61K31/712 , A61K31/7105 , A61P31/12
CPC分类号： C07H19/10 , A61K31/661 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07F9/65586 , C07F9/65744 , C07H19/11 , A61K2300/00
摘要： The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein, as well as to compositions and methods of using the Cyclic Phosphonate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
-
公开(公告)号：EP3169673A1
公开(公告)日：2017-05-24
申请号：EP15821775.2
申请日：2015-07-09
发明人： PASTERNAK, Alexander , DAVIES, Ian , DING, Fa-Xiang , DONG, Shuzhi , JIANG, Jinlong , GU, Xin
IPC分类号： C07D401/00
CPC分类号： C07D471/10 , A61K31/438 , A61K31/444 , A61K45/06
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
-
8.发明公开CYCLIC PHOSPHONATE SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权环磷酸酯取代的核苷衍生物及其用于治疗病毒疾病的方法
公开(公告)号：EP3010512A1
公开(公告)日：2016-04-27
申请号：EP14814201.1
申请日：2014-06-16
发明人： BOGEN, Stephane , GIRIJAVALLABHAN, Vinay , TRUONG, Quang , CHEN, Ping , BENNETT, Frank , KEREKES, Angela , DANG, Qun , OLSEN, David, B. , DAVIES, Ian
IPC分类号： A61K31/66 , A61K31/712 , A61K31/7105
CPC分类号： C07H19/10 , A61K31/661 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07F9/65586 , C07F9/65744 , C07H19/11 , A61K2300/00
摘要： The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein, as well as to compositions and methods of using the Cyclic Phosphonate Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的环状膦酸酯取代的核苷衍生物：（结构式）及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义，以及组合物和使用 用于治疗或预防患者HCV感染的环状膦酸酯取代的核苷衍生物。
-
9.发明公开2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权2'-氰基取代的核苷及使用方法进行病毒疾病治疗
公开(公告)号：EP2696679A2
公开(公告)日：2014-02-19
申请号：EP12770821.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , KEREKES, Angela , BENNETT, Frank , HUANG, Ying , NAIR, Latha , PISSARNITZKI, Dimitri , VERMA, Vishal , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA; Joseph, P.
CPC分类号： C07H19/16 , A61K31/7056 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/20 , C07H19/207 , C07H19/213 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395
摘要： The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
-
10.发明授权
公开(公告)号：EP2697242B1
公开(公告)日：2018-10-03
申请号：EP12771707.2
申请日：2012-04-11
发明人： GIRIJAVALLABHAN, Vinay , NJOROGE, F. George , BOGEN, Stephane , BENNETT, Frank , VERMA, Vishal , ARASAPPAN, Ashok , CHEN, Kevin , HUANG, Ying , KEREKES, Angela , NAIR, Latha , PISSARNITSKI, Dmitri , DANG, Qun , DAVIES, Ian , OLSEN, David, B. , STAMFORD, Andrew , VACCA, Joseph, P.
IPC分类号： C07H21/02 , C07H19/10 , C07H19/06 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213 , A61K45/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7072 , A61K31/708 , A61K31/7068 , A61P31/14
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.021 秒)
