-
公开(公告)号：EP1973889B1
公开(公告)日：2016-08-24
申请号：EP06849193.5
申请日：2006-12-29
发明人： ALI, Amjad , LU, Zhijian , SINCLAIR, Peter, J. , TAYLOR, Gayle, E. , THOMPSON, Christopher, F. , SMITH, Cameron, J. , DOWST, Adrian, A. , CHEN, Yi-heng
IPC分类号： C07D263/16 , A61K31/421
CPC分类号： C07D263/20 , C07D413/06 , C07D413/10 , C07D413/12
-
公开(公告)号：EP3188731B1
公开(公告)日：2019-04-03
申请号：EP15838154.1
申请日：2015-08-31
发明人： IMBRIGLIO, Jason , LONDON, Clare , LU, Zhijian , TATA, James , XIONG, Yusheng , YOU, Ming , YOUM, Hye Won
IPC分类号： A61K31/47 , A61P9/10 , C07D217/12
-
3.发明公开
公开(公告)号：EP3515891A1
公开(公告)日：2019-07-31
申请号：EP17853698.3
申请日：2017-09-15
发明人： IMBRIGLIO, Jason Eugene , PETRILLI, Whitney Lane , XIONG, Yusheng , FENG, Zhe , YOUM, Hyewon , CHANG, Wonsuk , LIANG, Rui , LU, Zhijian , TAYLOR, Jerry Andrew , HOYT, Scott, B.
IPC分类号： C07D217/16 , A61K31/472 , A61K31/4725 , C07D217/14
-
4.发明授权
公开(公告)号：EP3188730B1
公开(公告)日：2019-05-01
申请号：EP15837715.0
申请日：2015-08-31
发明人： IMBRIGLIO, Jason , LONDON, Clare , LU, Zhijian , TATA, James , XIONG, Yusheng , YOU, Ming , YOUM, Hye Won
IPC分类号： A61K31/47 , A61P9/10 , C07D217/06
-
5.发明公开TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 审中-公开用作二酰甘油O-乙酰转移酶2抑制剂的四氢异喹啉衍生物
公开(公告)号：EP3188730A1
公开(公告)日：2017-07-12
申请号：EP15837715.0
申请日：2015-08-31
发明人： IMBRIGLIO, Jason , LONDON, Clare , LU, Zhijian , TATA, James , XIONG, Yusheng , YOU, Ming , YOUM, Hye Won
IPC分类号： A61K31/47 , A61P9/10 , C07D217/06
CPC分类号： A61K31/47 , A61K31/16 , C07C13/04 , C07D217/06 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention relates to a compound represented by formula I:and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ("DGAT2") and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
摘要翻译： 本发明涉及由式I表示的化合物及其药学上可接受的盐。 式I化合物是二酰基甘油酯O-酰基转移酶2（“DGAT2”）的抑制剂并且可用于治疗，预防和抑制由DGAT2介导的疾病。 本发明化合物可用于治疗肝脂肪变性，糖尿病，肥胖症，高脂血症，高胆固醇血症，动脉粥样硬化，心肾疾病如慢性肾病和心力衰竭以及相关疾病和病症。
-
6.发明授权CYCLIC AMINE SUBSTITUTED OXAZOLIDINONES AS CETP INHIBITORS 有权ZYKLISCHE AMINSUBSTITUIERTE OXAZOLIDINON-VERBINDUNGEN ALS CETP-HEMMER
公开(公告)号：EP2632269B1
公开(公告)日：2017-03-15
申请号：EP11836937.0
申请日：2011-10-25
发明人： LU, Zhijian , CHEN, Yi-Heng , SMITH, Cameron , LI, Hong , THOMPSON, Christopher, F. , SWEIS, Ramzi , SINCLAIR, Peter , KALLASHI, Florida , HUNT, Julianne , ADAMSON, Samantha, E. , DONG, Guizhen , ONDEYKA, Debra, L. , QIAN, Xiaoxia , SUN, Wanying , VACHAL, Petr , ZHAO, Kake
IPC分类号： C07D413/14 , A61K31/422 , A61K31/506 , A61K31/4427 , A61P9/10 , A61P3/06
CPC分类号： C07D491/08 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/06 , C07D413/14 , C07D417/14 , A61K2300/00
-
7.发明公开ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 审中-公开可用作二酰甘油O-乙酰转移酶2抑制剂的异喹啉衍生物
公开(公告)号：EP3188731A1
公开(公告)日：2017-07-12
申请号：EP15838154.1
申请日：2015-08-31
发明人： IMBRIGLIO, Jason , LONDON, Clare , LU, Zhijian , TATA, James , XIONG, Yusheng , YOU, Ming , YOUM, Hye Won
IPC分类号： A61K31/47 , A61P9/10 , C07D217/12
CPC分类号： C07D417/12 , A61K45/06 , A61P9/10 , C07D217/02 , C07D217/12 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 ("DGAT2") and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio-renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
摘要翻译： 本发明涉及由式I表示的化合物及其药学上可接受的盐。 式I化合物是二酰基甘油酯O-酰基转移酶2（“DGAT2”）的抑制剂并且可用于治疗，预防和抑制由DGAT2介导的疾病。 本发明化合物可用于治疗肝脂肪变性，糖尿病，肥胖症，高脂血症，高胆固醇血症，动脉粥样硬化，心肾疾病如慢性肾病和心力衰竭以及相关疾病和病症。
-
公开(公告)号：EP1737811B1
公开(公告)日：2016-08-10
申请号：EP05736159.4
申请日：2005-04-08
发明人： ALI, Amjad , BOHN, Joann , DENG, Qiaolin , LU, Zhijian , SINCLAIR, Peter, J. , TAYLOR, Gayle, E. , THOMPSON, Christopher, F. , QURAISHI, Nazia
IPC分类号： C07C271/16 , C07C205/00 , C07C229/00 , C07D213/64 , A61P9/10 , A61K31/44
CPC分类号： C07C271/20 , C07C233/18 , C07C271/16 , C07C271/22 , C07C279/08 , C07C311/04 , C07C311/08 , C07C317/32 , C07D209/08 , C07D213/40 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/89 , C07D215/12 , C07D215/26 , C07D217/02 , C07D217/14 , C07D261/08 , C07D271/06 , C07D307/52 , C07D307/79 , C07D333/20 , C07D333/22 , C07D333/28
-
公开(公告)号：EP1971595B1
公开(公告)日：2013-10-16
申请号：EP06849230.5
申请日：2006-12-29
发明人： ALI, Amjad , LU, Zhijian , SINCLAIR, Peter, J. , CHEN, Yi-Heng , SMITH, Cameron, J. , LI, Hong , THOMPSON, Christopher, F.
IPC分类号： C07D403/02 , C07D263/16 , A61K31/4439 , A61K31/421
CPC分类号： C07D413/06 , C07D263/24
-
公开(公告)号：EP2632269A1
公开(公告)日：2013-09-04
申请号：EP11836937.0
申请日：2011-10-25
发明人： LU, Zhijian , CHEN, Yi-Heng , SMITH, Cameron , LI, Hong , THOMPSON, Christopher, F. , SWEIS, Ramzi , SINCLAIR, Peter , KALLASHI, Florida , HUNT, Julianne , ADAMSON, Samantha, E. , DONG, Guizhen , ONDEYKA, Debra, L. , QIAN, Xiaoxia , SUN, Wanying , VACHAL, Petr , ZHAO, Kake
CPC分类号： C07D491/08 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/06 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： CCompounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A
3 is a substitiuted phenyl group or indanyl group.Formula (I).
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.02 秒)
