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公开(公告)号：EP4100401A1
公开(公告)日：2022-12-14
申请号：EP21751452.0
申请日：2021-02-02
申请人： Merck Sharp & Dohme LLC , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , MCCAULEY, John A. , OLSEN, David B. , SLEEBS, Brad , TRIGLIA, Tony , ZHAN, Dongmei , ZHAO, Lianyun
IPC分类号： C07D401/10 , C07D403/10 , C07D417/10 , C07D471/04 , A61K31/513 , A61P33/06
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公开(公告)号：EP4013742A1
公开(公告)日：2022-06-22
申请号：EP20852190.6
申请日：2020-07-21
申请人： Merck Sharp & Dohme Corp. , THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH , MSD R&D (China) Co., Ltd.
发明人： MCCAULEY, John A. , COWMAN, Alan F. , DE LERA RUIZ, Manuel , FAVUZZA, Paola , GUO, Zhuyan , HU, Bin , KELLY III, Michael J. , LEI, Zhiyu , OLSEN, David B. , SLEEBS, Brad , THOMPSON, Jennifer K. , TRIGLIA, Tony , ZHAN, Dongmei , ZHANG, Cailing , ZHAO, Lianyun
IPC分类号： C07D239/22 , C07D405/04 , C07D405/14 , A61K31/513 , A61P33/06
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公开(公告)号：EP3116862B1
公开(公告)日：2019-04-17
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D513/08 , A61K31/554 , A61P31/18
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公开(公告)号：EP3116862A1
公开(公告)日：2017-01-18
申请号：EP15760695.5
申请日：2015-03-06
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BUNGARD, Christopher J. , BENNETT, David Jonathan , WADDELL, Sherman T. , MORRIELLO, Gregori J. , CHANG, Lehua , DWYER, Michael P. , HOLLOWAY, M. Katharine , CRESPO, Alejandro , CHU, Xin-Jie , WISCOUNT, Catherine , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , KEERTIKAR, Kartik M. , HU, Bin , ZHONG, Bin , JI, Tao
IPC分类号： C07D281/10 , C07D241/36
CPC分类号： C07D513/08 , A61K31/554 , A61K45/06
摘要： The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及式I化合物，包含其的药物组合物，以及它们在抑制HIV蛋白酶，抑制HIV复制，预防HIV感染，治疗HIV感染以及预防， 治疗和延缓艾滋病的发病或进展。
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5.发明公开
公开(公告)号：EP3027593A2
公开(公告)日：2016-06-08
申请号：EP14832049.2
申请日：2014-07-29
发明人： WILLIAMS, Peter D. , MCCAULEY, John A. , BENNETT, David J. , BUNGARD, Christopher J. , CHANG, Lehua , CHU, Xin-Jie , DWYER, Michael P. , HOLLOWAY, M. Katherine , KEERTIKAR, Kartik M. , LOUGHRAN, H. Marie , MANIKOWSKI, Jesse J. , MORRIELLO, Gregori J. , SHEN, Dong-Ming , SHERER, Edward C. , SCHULZ, Jurgen , WADDELL, Sherman Tim , WISCOUNT, Catherine M. , ZORN, Nicolas , SATYANARAYANA, Tummanapalli , VIJAYASARADHI, Sivalenka , HU, Bin , JI, Tao , ZHONG, Bin
IPC分类号： C07D295/088
CPC分类号： C07D241/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to piperazine derivatives, pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
摘要翻译： 本发明涉及哌嗪衍生物，包含它们的药物组合物及其在抑制HIV蛋白酶中的用途，HIV复制的抑制，HIV预防感染，HIV感染治疗以及预防，治疗 ，并延迟艾滋病的发病或进展。
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公开(公告)号：EP4188379A1
公开(公告)日：2023-06-07
申请号：EP21848925.0
申请日：2021-07-22
发明人： ZHANG, Yonglian , MCCAULEY, John A. , LO, Michael Man-Chu , GUO, Liangqin , ZHAO, Kake , BENNETT, Frank , KIM, Ronald M. , DEJESUS, Reynalda Keh , SHURTLEFF, Valerie W. , DE LERA RUIZ, Manuel , PLOTKIN, Michael A. , SU, Hua , FELLS, James , CROWLEY, Brendan M. , CHOBANIAN, Harry R. , EMBREY, Mark, W. , MORRIELLO, Gregori, J.
IPC分类号： A61K31/4738 , A61K31/53 , C07D253/10 , C07D471/04
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