公开(公告)号：EP1812090A1

公开(公告)日：2007-08-01

申请号：EP05814892.5

申请日：2005-10-28

申请人： Microchips, Inc.

发明人： CIMA, Michael J. ,  SANTINI JR., John T. ,  STAPLES, Mark Andrew ,  HUTCHINSON, Charles E.

IPC分类号： A61L27/54 ,  A61F2/44

CPC分类号： A61F2/30771 ,  A61B17/0642 ,  A61B17/80 ,  A61B17/86 ,  A61B17/8625 ,  A61B2017/0648 ,  A61C8/0012 ,  A61C8/0016 ,  A61C19/063 ,  A61F2/30744 ,  A61F2/30767 ,  A61F2/36 ,  A61F2/3662 ,  A61F2/367 ,  A61F2/3676 ,  A61F2/38 ,  A61F2/3804 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/40 ,  A61F2/4425 ,  A61F2/446 ,  A61F2002/2817 ,  A61F2002/30013 ,  A61F2002/30032 ,  A61F2002/30036 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30075 ,  A61F2002/30224 ,  A61F2002/30324 ,  A61F2002/30326 ,  A61F2002/30677 ,  A61F2002/3068 ,  A61F2002/30787 ,  A61F2002/30808 ,  A61F2002/3081 ,  A61F2002/30838 ,  A61F2002/30878 ,  A61F2002/30929 ,  A61F2002/30971 ,  A61F2002/3611 ,  A61F2002/3625 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2210/0004 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0024 ,  A61F2250/003 ,  A61F2250/0035 ,  A61F2250/0036 ,  A61F2250/0037 ,  A61F2250/0068 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00131 ,  A61F2310/00179 ,  A61L27/54 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/604 ,  A61N1/30

摘要： Implantable prosthetic devices are provided for controlled drug delivery, for orthopedic and dental applications. The device may include a prosthetic device body having at least one outer surface area; two or more discrete reservoirs located in spaced apart positions across at least a portion of the outer surface area, the reservoirs formed with an opening at the surface of the device body and extending into the device body; and a release system disposed in the reservoirs which comprises at least one therapeutic or prophylactic agent, wherein following implantation into a patient the therapeutic or prophylactic agent is released in a controlled manner from the reservoirs. The prosthetic device body preferably is a joint prosthesis or part thereof, such as a hip prosthesis, a knee prosthesis, a vertebral or spinal disc prosthesis, or part thereof. Optional reservoir caps may further control release kinetics.