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公开(公告)号：EP2016072B1
公开(公告)日：2014-07-16
申请号：EP07761905.4
申请日：2007-05-04
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/4178 , A61P9/00
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
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公开(公告)号：EP1216228A2
公开(公告)日：2002-06-26
申请号：EP00963452.8
申请日：2000-09-15
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Eric , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D417/12 , A61K31/18 , A61K31/33 , A61P7/02
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP1216231A2
公开(公告)日：2002-06-26
申请号：EP00963451.0
申请日：2000-09-15
发明人： ZHU, Bing-Yan , JIA, Zhaozhong, Jon , HUANG, Wenrong , SONG, Yonghong , KANTER, James , SCARBOROUGH, Robert, M.
IPC分类号： C07D231/14 , C07D277/56 , C07D401/12 , C07D417/04 , A61K31/33 , A61P7/04
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of formula A Q D E G J X in which D is a direct link, a substituted or unsubsituted phenyl or naphtyl gourp or a heterocyclic ring system; G is substituted or unsubstituted phenyl or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphtyl group or a heterocyclic ring system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed, The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP2114928A2
公开(公告)日：2009-11-11
申请号：EP08705691.7
申请日：2008-01-04
发明人： ZHU, Bing-yan , BAUER, Shawn M. , JIA, Zhaozhong J. , SONG, Yonghong , PROBST, Gary D. , ZHANG, Yanchen , SCARBOROUGH, Carroll
IPC分类号： C07D409/12 , C07D409/14 , C07D413/14 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/421 , A61P9/00
CPC分类号： C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：EP2016072A1
公开(公告)日：2009-01-21
申请号：EP07761905.4
申请日：2007-05-04
IPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K31/4178 , A61P9/00
CPC分类号： C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such a compound, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译： 本发明涉及作为因子Xa抑制剂的式（I）化合物及其药学上可接受的盐，酯和前药。 本发明还涉及用于制备这样的化合物的中间体，含有该化合物的药物组合物，预防或治疗许多以不希望的血栓形成为特征的病症的方法和抑制血液样品凝固的方法。
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公开(公告)号：EP1322610A2
公开(公告)日：2003-07-02
申请号：EP01975505.7
申请日：2001-10-01
发明人： ZHU, Bing-Yan , JIA, Zhaozhong, Jon , ZHANG, Penglie , HUANG, Wenrong , WU, Yanhong , ZUCKETT, Jingmei, Fan , GOLDMAN, Erik, A. , WANG, Lingyan , SONG, Yonghong , SCARBOROUGH, Robert, M.
IPC分类号： C07D209/30
CPC分类号： C07D239/06 , C07D205/04 , C07D209/30 , C07D233/06 , C07D295/26 , C07D333/62 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14
摘要： Novel compounds of the general formulae (I) or (II), including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and the compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
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公开(公告)号：EP2114930A2
公开(公告)日：2009-11-11
申请号：EP08713578.6
申请日：2008-01-04
IPC分类号： C07D409/14
CPC分类号： C07D409/14 , C07D413/14 , C07D417/14
摘要： The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat certain conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号：EP1216228B1
公开(公告)日：2008-10-29
申请号：EP00963452.8
申请日：2000-09-15
发明人： ZHU, Bing-Yan , ZHAN, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Eric , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14 , C07D417/12 , A61K31/18 , A61K31/33 , A61P7/02
CPC分类号： C07D213/75 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/56 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： Compounds of the formula A - Q - D - E - G - J - X in which D is a direct link, a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic ring system; X is a substituted or unsubstituted phenyl or naphthyl group or a heterocyclic system; and the other variables are as defined in the claims, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
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公开(公告)号：EP1259485B1
公开(公告)日：2005-11-30
申请号：EP01918257.5
申请日：2001-02-28
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Erick , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07D213/75 , C07D401/12 , A61K31/44 , A61P7/02
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described Compositions containing such compounds are also described The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders
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公开(公告)号：EP1259485A2
公开(公告)日：2002-11-27
申请号：EP01918257.5
申请日：2001-02-28
发明人： ZHU, Bing-Yan , ZHANG, Penglie , WANG, Lingyan , HUANG, Wenrong , GOLDMAN, Erick , LI, Wenhao , ZUCKETT, Jingmei , SONG, Yonghong , SCARBOROUGH, Robert
IPC分类号： C07D213/75 , C07D401/12 , A61K31/44 , A61P7/02
CPC分类号： A61K31/44 , A61K9/20 , A61K9/2013 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/616 , A61K45/06 , A61K2201/094 , C07C237/42 , C07C255/60 , C07C257/18 , C07C259/18 , C07C311/16 , C07C311/46 , C07C317/40 , C07C317/44 , C07D213/75 , C07D213/81 , C07D213/82 , C07D217/22 , C07D231/12 , C07D233/56 , C07D233/64 , C07D249/08 , C07D295/125 , C07D333/38 , C07D401/12 , C07D409/12 , C07D409/14
摘要： Novel benzamide compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described Compositions containing such compounds are also described The compounds and compositions are useful in vitro or in vivo for preventing or treating coagulation disorders
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