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公开(公告)号：EP2690084B1
公开(公告)日：2017-04-19
申请号：EP12763641.3
申请日：2012-03-23
申请人： NOF Corporation
IPC分类号： C07C41/58 , C07C43/315
CPC分类号： C07C41/58 , C07C43/315
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公开(公告)号：EP1564236B1
公开(公告)日：2008-03-05
申请号：EP03811545.7
申请日：2003-11-20
申请人： NOF CORPORATION
发明人： NAKAMOTO, Ken-ichiro , OHHASHI, Shunsuke , YAMAMOTO, Yuji , SAKANOUE, Kenji , ITOH, Chika , YASUKOHCHI, Tohru
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified biological substance having, per molecule, at least one polyalkylene glycoloxy group represented by the following formula (1): (1) wherein R is a C1-24 hydrocarbon group and OA1 and OA2 each is C2-4 oxyalkylene, provided that R and OA2 in the same molecule are the same or different; and n and m, which indicate the average number of moles of the oxyalkylene added, are 0 to 1,000 and 10 to 1,000, respectively.
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3.发明公开MODIFIED BIOLOGICAL SUBSTANCE, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATE 有权POLYALKYLINGLYKOL DERIVAT
公开(公告)号：EP1564236A1
公开(公告)日：2005-08-17
申请号：EP03811545.7
申请日：2003-11-20
申请人： NOF Corporation
发明人： NAKAMOTO, Ken-ichiro , OHHASHI, Shunsuke , YAMAMOTO, Yuji , SAKANOUE, Kenji , ITOH, Chika , YASUKOHCHI, Tohru
CPC分类号： C08G65/329 , A61K47/60 , C08G65/2609
摘要： A modified bio-related substance, wherein at least one poly(alkylene glycol)oxy group represented by the following formula (1) is combined in a molecule:
wherein R is a hydrocarbon group having 1 to 24 carbon atoms, OA 1 and OA 2 are each an oxyalkylene group having 2 to 4 carbon atoms, R and OA 2 are the same or different from each other in one molecule, n and m are each average number of moles of the oxyalkylene group added, n represents 0 to 1000, and m represents 10 to 1000.摘要翻译： 一种改性的生物相关物质，其中至少一种由下式（1）表示的聚（亚烷基二醇）氧基在分子中组合：
其中R是具有1至24个碳原子的烃基， 1和OA 2各自为具有2〜4个碳原子的氧化烯基，R 1和OA 2在一个分子中彼此相同或不同，n和m各自是氧化烯基的平均摩尔数 n表示0〜1000，m表示10〜1000。 -
4.发明公开
公开(公告)号：EP3355946A1
公开(公告)日：2018-08-08
申请号：EP16787588.9
申请日：2016-09-30
发明人： EDELMAN, Elazer , ARTZI, Natalie , SONG, Hyun Seok , YAMAMOTO, Yuji , YOSHIOKA, Hiroki , NAKAMOTO, Ken-ichiro
CPC分类号： C08J3/246 , A61K9/0024 , A61L27/18 , A61L27/20 , A61L27/38 , A61L27/3834 , A61L27/52 , A61L27/54 , A61L2400/06 , C08J2305/02 , C08J2343/02 , C08J2371/02 , C08L71/02
摘要： Provided herein are narrowly distributed multi-armed polyethylene glycol compounds, and hydrogels containing the same. Also provided are methods for treating, adhering, or sealing a biological tissue with hydrogels, and kits for making a hydrogel. Drug releasing compositions also are provided that include a narrowly distributed multi-armed polyethylene glycol compound.
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