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    REFINING METHOD FOR POLYETHYLENE GLYCOL WITH ONE CARBOXYL GROUP
    2.
    发明公开
    REFINING METHOD FOR POLYETHYLENE GLYCOL WITH ONE CARBOXYL GROUP 审中-公开

    公开(公告)号：EP3604382A1

    公开(公告)日：2020-02-05

    申请号：EP18776926.0

    申请日：2018-03-22

    申请人： NOF Corporation

    发明人： HIRAI, Midori ,  YOSHIOKA, Hiroki

    IPC分类号： C08G65/30

    摘要： To provide a purification method of a polyethylene glycol compound having one carboxyl group, which can purify the polyethylene glycol compound efficiently and in a good purity, which does not generate a waste, for example, an adsorbent or an ion-exchange resin, and which is industrially feasible. An aqueous solution of the polyethylene glycol compound having a pH of 8 to 11 is prepared. The aqueous solution and a mixed organic solvent are mixed at a temperature of 15°C or more and 50°C or less and the mixture is separated into an organic layer and an aqueous layer. In the mixed organic solvent, a ratio of an organic solvent I is from 25 to 60% by mass, and a ratio of an organic solvent II is from 75 to 40% by mass. The organic solvent I is a hydrocarbon solvent selected from toluene, xylene, and the like, the organic solvent II is a halogenated hydrocarbon solvent selected from chloroform, and the like, and a mixing ratio Y of the organic solvent I to the organic solvent II (organic solvent I/organic solvent II), a temperature T (°C) at the time of the mixing and a weight average molecular weight M of the polyethylene glycol compound satisfy the relationship of 3.11 × 10 -6 M + 0.084 ≤ Y - 0.0135T ≤ -1.77 × 10 -6 M + 0.404.

    METHOD FOR PRODUCING MULTI-ARM TYPE POLYETHYLENE GLYCOL DERIVATIVE
    4.
    发明公开
    METHOD FOR PRODUCING MULTI-ARM TYPE POLYETHYLENE GLYCOL DERIVATIVE 审中-公开

    公开(公告)号：EP3778704A1

    公开(公告)日：2021-02-17

    申请号：EP19776510.0

    申请日：2019-03-27

    申请人： NOF Corporation

    发明人： ONOZAWA, Akihide ,  YOSHIOKA, Hiroki ,  KAMIYA, Masaki

    IPC分类号： C08G65/329

    摘要： A method for producing a multi-arm type polyethylene glycol derivative, wherein the following steps are carried out in this order: Step (A): a step of protecting an even number of hydroxyl groups, while leaving only the hydroxyl group at the 1-position of a polyhydric alcohol having an odd number of hydroxyl groups, other than the hydroxyl group at the 1-position by cyclic benzylidene acetalization, Step (B): a step of linking two molecules of the compound obtained in the step (A) to a compound for introducing a specific linker by an etherification reaction, Step (C): a step of deprotecting the cyclic benzylidene acetal structure at the terminal of the compound obtained in the step (B), Step (D): a step of polymerizing 3 to 600 mol of ethylene oxide to each hydroxyl group of the compound obtained in the step (C) to obtain a multi-arm type polyethylene glycol derivative, and Step (E): a step of functionalizing the hydroxyl group at the terminal of the multi-arm type polyethylene glycol derivative obtained in the step (D).

    NOVEL CATIONIC LIPID EXHIBITING IMPROVED INTRACELLULAR DYNAMICS
    5.
    发明公开
    NOVEL CATIONIC LIPID EXHIBITING IMPROVED INTRACELLULAR DYNAMICS 审中-公开

    公开(公告)号：EP3778572A1

    公开(公告)日：2021-02-17

    申请号：EP19778026.5

    申请日：2019-03-25

    申请人： NOF Corporation ,  National University Corporation Chiba University

    发明人： NAKAI, Yuta ,  TANGE, Kota ,  YOSHIOKA, Hiroki ,  TAMAGAWA, Shinya ,  AKITA, Hidetaka ,  TANAKA, Hiroki ,  TAKATA, Nae ,  KONISHI, Manami ,  TAKAHASHI, Tatsunari

    IPC分类号： C07D211/22 ,  A61K47/22 ,  A61K48/00 ,  C07D405/14

    摘要： Provided are a cationic lipid having improved intracellular kinetics, a lipid membrane structure containing same, and use thereof.
    A cationic lipid represented by the formula (1)

    (in the formula (1),
    R 1a and R 1b are each independently an alkylene group having 1 - 6 carbon atoms,
    X a and X b are each independently a non-cyclic alkyl tertiary amino group having 1 - 6 carbon atoms and one tertiary amino group, or a cyclic alkylene tertiary amino group having 2 - 5 carbon atoms and 1 - 2 tertiary amino groups,
    R 2a and R 2b are each independently an alkylene group or an oxydialkylene group each having not more than 8 carbon atoms,
    Y a and Y b are each independently an ester bond, an amide bond, a carbamate bond, an ether bond or a urea bond,
    Z a and Z b are each independently a divalent group derived from an aromatic compound having 3 - 16 carbon atoms and at least one aromatic ring, and optionally having a hetero atom, and
    R 3a and R 3b are each independently a residue derived from a reaction product of a liposoluble vitamin having a hydroxyl group, and succinic anhydride or glutaric anhydride, or a residue derived from a reaction product of a sterol derivative having a hydroxyl group, and succinic anhydride or glutaric anhydride, or an aliphatic hydrocarbon group having 12 - 22 carbon atoms).