公开(公告)号：EP3416948A1

公开(公告)日：2018-12-26

申请号：EP17705416.0

申请日：2017-02-16

申请人： The University Of Queensland ,  The Provost, Fellows, Foundation Scholars, and the other members of Board, of the College of the Holy & Undiv. Trinity of Queen Elizabeth near Dublin

发明人： O'NEILL, Luke ,  COLL, Rebecca ,  COOPER, Matthew ,  ROBERTSON, Avril ,  SCHRODER, Kate ,  MACLEOD, Angus Murray ,  MILLER, David John

IPC分类号： C07D231/18 ,  C07C307/06 ,  C07C307/08 ,  C07C307/10 ,  C07D295/26 ,  A61P29/00

CPC分类号： C07D295/26 ,  C07C307/06 ,  C07C307/10 ,  C07C2601/14 ,  C07C2602/08 ,  C07C2603/10 ,  C07D231/18

摘要： The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts, solvates and prodrugs thereof: Formula (I) wherein Q is selected from O, S and Se; J is S or Se; W1 and W2, when present, are independently selected from N and C; R1 and R2 are independently selected from the group consisting of hydrogen, C1-C12alkyl, C2-C12alkenyl, C2-C12alkynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, cycloalkenyl, amino, amido, alkylthio, acyl, arylalkyl and acylamido, all of which may be optionally substituted; and wherein at least one of W1 and W2 is present and is a nitrogen atom and when R1 and R2 are cyclic then the respective W1 or W2 may form part of the ring structure. The present invention also relates to pharmaceutical compositions including such compounds, to methods of treatment using such compounds, in particular in relation to NLRP3 inflammasome mediated disorders, and to associated diagnostic uses.

公开(公告)号：EP2870129A1

公开(公告)日：2015-05-13

申请号：EP13747940.8

申请日：2013-08-06

申请人： Promerus, LLC

发明人： BELL, Andrew ,  LANGSDORF, Leah ,  BURTOVYY, Oleksandr

IPC分类号： C07C13/42 ,  C07C13/465 ,  C07C13/50 ,  C07C13/547 ,  C07C13/573 ,  C07C13/605 ,  C07C13/61 ,  C07C13/615 ,  C07C13/64 ,  C07C13/68 ,  C07C43/188 ,  C08F32/00 ,  C12P7/16 ,  C12P7/22 ,  B01D71/26

CPC分类号： C08F232/08 ,  B01D61/362 ,  B01D67/0009 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/26 ,  B01D71/44 ,  B01D71/76 ,  B01D71/82 ,  B01D2325/20 ,  C07C13/40 ,  C07C13/42 ,  C07C13/465 ,  C07C13/47 ,  C07C13/50 ,  C07C13/54 ,  C07C13/547 ,  C07C13/573 ,  C07C13/605 ,  C07C13/61 ,  C07C13/615 ,  C07C13/64 ,  C07C13/68 ,  C07C29/76 ,  C07C37/82 ,  C07C2602/42 ,  C07C2603/10 ,  C07C2603/28 ,  C07C2603/62 ,  C07C2603/64 ,  C07C2603/66 ,  C07C2603/74 ,  C07C2603/90 ,  C07C2603/91 ,  Y02E50/17 ,  C07C31/12 ,  C07C39/04

摘要： Embodiments in accordance with the present invention provide forming various polycycloalkyl polynorbornene polymers and copolymers which are useful for forming pervaporation membranes, the membranes themselves and methods of making such membranes.

公开(公告)号：EP1819749B1

公开(公告)日：2010-10-27

申请号：EP05817915.1

申请日：2005-12-06

申请人： Merck Patent GmbH

发明人： HEUN, Susanne ,  PARHAM, Amir ,  LUDEMANN, Aurelie

IPC分类号： C08G61/10 ,  C08G61/02 ,  C07C43/225 ,  C07C211/56 ,  C07C25/22

CPC分类号： C08G61/10 ,  C07C25/22 ,  C07C43/225 ,  C07C211/56 ,  C07C2603/10 ,  C08G61/02 ,  C09B23/14 ,  C09B57/00 ,  C09B57/008 ,  C09B69/105 ,  C09B69/109

公开(公告)号：EP2213639A1

公开(公告)日：2010-08-04

申请号：EP08852665.2

申请日：2008-11-13

申请人： Idemitsu Kosan Co., Ltd.

发明人： KAWAMURA, Masahiro

IPC分类号： C07C15/20 ,  C07C13/567 ,  C09K11/06 ,  H01L51/50

CPC分类号： H01L51/0055 ,  C07C13/567 ,  C07C15/20 ,  C07C2603/10 ,  C07C2603/18 ,  C07C2603/26 ,  C07C2603/50 ,  C07C2603/52 ,  C07D307/91 ,  C07D333/08 ,  C07D333/76 ,  C09B1/00 ,  C09B57/00 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1088 ,  C09K2211/1092 ,  H01L51/0052 ,  H01L51/0054 ,  H01L51/0058 ,  H01L51/0059 ,  H01L51/0071 ,  H01L51/0085 ,  H01L51/0087 ,  H01L51/5012 ,  H05B33/14 ,  Y10S428/917

摘要： A monobenzochrysene derivative shown by the following formula (1):

wherein R 1 to R 14 are independently a hydrogen atom or a substituent, and at least one of R 1 to R 14 is a substituted or unsubstituted aryl group having 6 to 50 ring carbon atoms which does not contain an anthracene skeleton and a benzo[g]chrysene skeleton or a substituted or unsubstituted heteroaryl group having 5 to 50 ring carbon atoms which does not contain an anthracene skeleton and a benzo[g]chrysene skeleton, excluding the case where R 8 and R 9 are unsubstituted phenyl groups and R 1 to R 7 and R 10 to R 14 are hydrogen atoms and the case where R 9 is an unsubstituted phenyl group and R 1 to R 8 and T 10 to R 14 are hydrogen atoms.

公开(公告)号：EP1904470B1

公开(公告)日：2009-08-26

申请号：EP06762522.8

申请日：2006-07-11

申请人： Merck Patent GmbH

发明人： CZANTA, Markus ,  PAULUTH, Detlef ,  LIETZAU, Lars

IPC分类号： C07D317/70 ,  C07C22/00 ,  C09K19/32 ,  C09K19/34

CPC分类号： C09K19/32 ,  C07C22/08 ,  C07C23/38 ,  C07C2601/14 ,  C07C2603/10 ,  C07D317/70 ,  C09K2019/327 ,  C09K2019/3408 ,  C09K2019/3422 ,  Y10T428/10

摘要： The invention relates to 1,2,3,6,7,8-hexahydro-s-indacene-derivatives and 6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-derivatives of formula (I), wherein R1, A1, Z1, n, X and Y have the meaning defined in the claims. The invention also relates to the use thereof as component(s) in liquid-crystal substances. The invention further relates to liquid-crystal and electro-optical display elements which contain the inventive liquid-crystal substances.

摘要翻译： 本发明涉及1,2,3,6,7,8-六氢 - 均不对称引达省衍生物和6,7-二氢-5H-茚并[5,6-d] -1,3-二恶茂衍生物，以及使用 其作为液晶介质成分（S）。 此外，本发明涉及一种液晶和其含有的液晶介质gemäß发明的电光显示元件。

公开(公告)号：EP1628654A2

公开(公告)日：2006-03-01

申请号：EP04776104.4

申请日：2004-05-24

申请人： United Therapeutics Corporation

发明人： PHARES, Ken ,  MOTTOLA, David

IPC分类号： A61K31/19 ,  A61K31/557

CPC分类号： C07C59/13 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/192 ,  A61K31/216 ,  A61K31/223 ,  A61K31/235 ,  C07C51/412 ,  C07C59/70 ,  C07C69/712 ,  C07C229/08 ,  C07C235/06 ,  C07C235/08 ,  C07C259/06 ,  C07C2103/10 ,  C07C2603/10 ,  C07F9/091 ,  C07F9/117

摘要： This invention pertains generally to prostacyclin analogs and methods for their use in promoting vasodilation, inhibiting platelet aggregation and thrombus formation, stimulating thrombolysis, inhibiting cell proliferation (including vascular remodeling), providing cytoprotection, preventing atherogenesis and inducing angiogenesis. Generally, the compounds and methods of the present invention increase the oral bioavailability and circulating concentrations of treprostinil when administered orally. Compounds of the present invention have formula (I).

公开(公告)号：EP0388977A2

公开(公告)日：1990-09-26

申请号：EP90105572.3

申请日：1990-03-23

申请人： WARNER-LAMBERT COMPANY

发明人： Bigge, Christopher Franklin ,  Hays, Sheryl Jeanne ,  Johnson, Graham ,  Novak, Perry Michael ,  Ortwine, Daniel Fred

IPC分类号： C07C211/42 ,  A61K31/13 ,  C07D311/80 ,  C07D333/76 ,  C07D333/74 ,  A61K31/35 ,  A61K31/38 ,  C07D221/16 ,  A61K31/435

CPC分类号： C07D209/48 ,  C07C45/511 ,  C07C45/562 ,  C07C45/59 ,  C07C45/68 ,  C07C49/67 ,  C07C49/697 ,  C07C49/753 ,  C07C61/39 ,  C07C62/34 ,  C07C69/00 ,  C07C211/42 ,  C07C215/44 ,  C07C217/52 ,  C07C225/20 ,  C07C233/06 ,  C07C235/40 ,  C07C243/36 ,  C07C247/10 ,  C07C271/24 ,  C07C271/36 ,  C07C395/00 ,  C07C2601/18 ,  C07C2603/00 ,  C07C2603/10 ,  C07C2603/18 ,  C07C2603/26 ,  C07C2603/30 ,  C07D211/74 ,  C07D221/16 ,  C07D265/34 ,  C07D307/00 ,  C07D311/58 ,  C07D311/80 ,  C07D315/00 ,  C07D317/72 ,  C07D333/54 ,  C07D333/74 ,  C07D335/02 ,  C07D335/04 ,  C07D335/06 ,  C07D335/10 ,  C07F7/0812 ,  C07F7/0818

摘要： A novel series of polycyclic amine derivatives, of formula I
methods of making the compounds, novel intermediates, compositions containing them, and pharmaceutical compositions useful in the treatment and prevention of cerebrovascular disorders and useful as anesthetics or analgesics.

摘要翻译： 制备化合物，新型中间体，含有它们的组合物的式I 方法的新型系列多环胺衍生物和可用于治疗和预防脑血管障碍并用作麻醉剂或止痛剂的药物组合物。

公开(公告)号：EP2757086A1

公开(公告)日：2014-07-23

申请号：EP13198696.0

申请日：2013-12-20

申请人： Heesung Material Ltd.

发明人： Lee, Jun-A ,  Park, Geon-Yu ,  Yang, Jeong-Hoon ,  Eum, Sung-Jin ,  Lee, Joo-Dong

IPC分类号： C07C13/547 ,  H01L51/00 ,  C09K11/06 ,  C07D403/14 ,  C07D263/57 ,  C07D209/08 ,  C07D277/66 ,  C07D209/86 ,  C07C211/60 ,  C07C49/792 ,  C07C13/567 ,  C07C13/62 ,  C07C13/66 ,  C07D213/38

CPC分类号： H01L51/0052 ,  C07C13/547 ,  C07C13/567 ,  C07C13/62 ,  C07C13/66 ,  C07C211/60 ,  C07C2602/08 ,  C07C2603/10 ,  C07C2603/18 ,  C07C2603/20 ,  C07C2603/24 ,  C07C2603/26 ,  C07C2603/40 ,  C07C2603/50 ,  C07C2603/52 ,  C07C2603/54 ,  C07D403/14 ,  C09K11/06 ,  C09K2211/1011 ,  C09K2211/1029 ,  C09K2211/1033 ,  C09K2211/1037 ,  C09K2211/1059 ,  C09K2211/1088 ,  H01L51/0056 ,  H01L51/0058 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/0074 ,  H01L51/0081 ,  H01L51/5012 ,  H01L2251/308

摘要： The present invention relates to a hydrocarbon-based fused ring compound and an organic light emitting device including the same.

摘要翻译： 本发明涉及一种基于烃的稠环化合物和有机发光器件，包括相同的。

公开(公告)号：EP2185496A1

公开(公告)日：2010-05-19

申请号：EP08794934.3

申请日：2008-07-31

申请人： Northwestern University

发明人： MARKS, Tobin, J. ,  FACCHETTI, Antonio ,  USTA, Hakan

IPC分类号： C07C49/665 ,  C07C49/697 ,  C07C255/34 ,  C07C255/35 ,  C07D333/22 ,  C07D333/24 ,  C07D333/28 ,  C08G61/00 ,  C08G61/02 ,  C08G61/10 ,  C08G61/12 ,  H01L51/00

CPC分类号： C07C49/697 ,  C07C17/12 ,  C07C45/46 ,  C07C45/63 ,  C07C45/65 ,  C07C49/665 ,  C07C255/34 ,  C07C255/35 ,  C07C2603/10 ,  C07C2603/52 ,  C07D333/22 ,  C07D333/24 ,  C07D333/28 ,  C08G61/02 ,  C08G61/12 ,  C08G61/123 ,  C08G61/126 ,  H01L51/0036 ,  H01L51/0043 ,  H01L51/0051 ,  H01L51/0055 ,  H01L51/0068 ,  H01L51/0545 ,  Y02E10/549 ,  C07C25/02

摘要： Disclosed are new conjugated compounds (e.g., monomers and polymers) that include ladder-type moieties which can be used for preparing semiconducting materials. Such conjugated compounds can exhibit high n-type carrier mobility and/or good current modulation characteristics. Compounds of the present teachings also can exhibit ambipolar semiconducting activity. In addition, the compounds of the present teachings can possess certain processing advantages such as solution- processability and/or good stability in ambient conditions.

摘要翻译： 本发明公开了新的共轭化合物（例如，单体和聚合物）确实包括阶梯型部分，其可用于制备半导体材料。 搜索共轭系化合物可表现出高的n型载流子迁移率和/或良好的电流调制特性。 本发明教导的化合物如此可表现出双极性半导体活性。 此外，本发明教导的化合物可以具有某些加工优势：例如溶液加工性和/或良好的稳定性在环境条件下。

公开(公告)号：EP1904470A1

公开(公告)日：2008-04-02

申请号：EP06762522.8

申请日：2006-07-11

申请人： Merck Patent GmbH

发明人： CZANTA, Markus ,  PAULUTH, Detlef ,  LIETZAU, Lars

IPC分类号： C07D317/70 ,  C07C22/00 ,  C09K19/32 ,  C09K19/34

CPC分类号： C09K19/32 ,  C07C22/08 ,  C07C23/38 ,  C07C2601/14 ,  C07C2603/10 ,  C07D317/70 ,  C09K2019/327 ,  C09K2019/3408 ,  C09K2019/3422 ,  Y10T428/10

摘要： The invention relates to 1,2,3,6,7,8-hexahydro-s-indacene-derivatives and 6,7-dihydro-5H-indeno[5,6-d][1,3]dioxol-derivatives of formula (I), wherein R1, A1, Z1, n, X and Y have the meaning defined in the claims. The invention also relates to the use thereof as component(s) in liquid-crystal substances. The invention further relates to liquid-crystal and electro-optical display elements which contain the inventive liquid-crystal substances.