-
公开(公告)号：EP2842553A1
公开(公告)日：2015-03-04
申请号：EP13782289.6
申请日：2013-04-26
IPC分类号： A61K31/16 , A61K9/08 , A61K9/20 , A61K9/70 , A61K31/231 , A61K31/265 , A61K47/40 , A61P19/02 , A61P29/00
CPC分类号： A61K31/40 , A61K9/0019 , A61K9/0053 , A61K31/16 , A61K31/165 , A61K31/231 , A61K31/265 , A61K47/40 , A61K47/48969 , A61K47/6951
摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing at least one member selected from a trans-2-decenoic acid derivative represented by the formula (1) and a pharmaceutically acceptable salt thereof as an active ingredient:
(In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group). The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis).摘要翻译： 本发明的目的是提供对各种疼痛疾病的预防或治疗有效的止痛剂。 本发明提供含有选自式（1）所示的反式-2-癸烯酸衍生物及其药学上可接受的盐中的至少一种作为有效成分的止痛剂：（式中，Y为-O - ， - NR-或-S-，R为氢原子，烷基，二烷基氨基烷基等，W为取代基如二烷基氨基烷基）。 含有该化合物作为有效成分的本发明的止痛剂作为骨关节炎引起的疼痛等各种疼痛疾病（例如膝骨关节炎，髋骨关节炎）的预防或治疗剂非常有用。
-
公开(公告)号：EP2636666A1
公开(公告)日：2013-09-11
申请号：EP11838046.8
申请日：2011-11-01
IPC分类号： C07C219/20 , A61K31/16 , A61K31/165 , A61K31/231 , A61K31/255 , A61K31/40 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07C217/08 , C07C233/09 , C07C233/38 , C07C327/30
CPC分类号： C07C327/30 , A61K31/231 , C07C57/02 , C07C69/533 , C07C217/08 , C07C219/08 , C07C219/20 , C07C233/09 , C07C233/38 , C07C323/12 , C07C327/22 , C07C2601/08 , C07C2601/14 , C07D295/13
摘要： An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1):
(In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury or an alleviating agent for side effect induced by administration of anti-cancer agents.摘要翻译： 本发明的目的在于提供一种新的反式-2-癸烯酸衍生物或其药学上可接受的盐，并提供含有该化合物作为活性成分并具有高安全性的神经营养因子样活性或 缓解由于施用抗癌剂引起的副作用的作用。 作为本发明化合物的反式-2-癸烯酸衍生物或其药学上可接受的盐具体由式（1）表示：（式中，Y为-O - ， - NR-或-S- ，R为氢原子，烷基，二烷基氨基烷基等，W为二烷基氨基烷基等取代基），作为痴呆症，阿尔茨海默氏病，帕金森病等的预防或治疗剂， 抑郁症等，通过给予抗癌剂诱发的脊髓损伤的治疗或修复剂或副作用的缓解剂。
-
3.发明公开PROPHYLACTIC OR THERAPEUTIC DRUG FOR PERIPHERAL NEUROPATHY CAUSED BY ANTICANCER AGENT 审中-公开PROPHYLAKTISCHES UNDEREREUTISCHES MITTELFÜRDURCH ANTIKREBSMITTEL VERURSACHTE PERIPHERE NEUROPATHIEN
公开(公告)号：EP2671578A1
公开(公告)日：2013-12-11
申请号：EP12742127.9
申请日：2012-01-30
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , OKADA, Tomoyuki , MATSUMOTO, Tomonori , SAWADA, Kazuyoshi
IPC分类号： A61K31/201 , A61P25/02
CPC分类号： C07C69/533 , A61K9/0019 , A61K9/0095 , A61K9/10 , A61K31/23 , A61K31/231 , A61K45/06 , A61K47/6951 , B82Y5/00
摘要： An object of the present invention is to provide a drug which is effective for prophylaxis or therapy of peripheral nerve disorder occurred as a side effect of the administration of anti-cancer agents.
The present invention is to provide a drug containing an ester of C 10 fatty acid as an active ingredient for prophylaxis or therapy of peripheral nerve disorder induced by administration of a drug containing at least one of anti-cancer agents. The drug of the present invention containing the compound as an active ingredient is highly useful as a drug for prophylaxis or therapy of peripheral nerve disorder induced by administration of anti-cancer agents.摘要翻译： 本发明的目的是提供一种对预防或治疗作为施用抗癌剂的副作用发生的周围神经障碍有效的药物。 本发明提供一种含有C 10脂肪酸的酯作为活性成分的药物，用于预防或治疗通过施用含有至少一种抗癌剂的药物而引起的周围神经障碍。 含有该化合物作为活性成分的本发明药物作为用于预防或治疗通过施用抗癌剂诱发的周围神经障碍的药物是非常有用的。
-
公开(公告)号：EP2636666B1
公开(公告)日：2018-01-10
申请号：EP11838046.8
申请日：2011-11-01
IPC分类号： C07C219/20 , A61K31/165 , A61K31/231 , A61K31/255 , A61K31/40 , A61P25/02 , A61P25/14 , A61P25/28 , A61P43/00 , C07C217/08 , C07C233/09 , C07C233/38 , C07C327/30 , C07C327/22 , C07D295/13 , C07C69/533 , C07C323/12
CPC分类号： C07C327/30 , A61K31/231 , C07C57/02 , C07C69/533 , C07C217/08 , C07C219/08 , C07C219/20 , C07C233/09 , C07C233/38 , C07C323/12 , C07C327/22 , C07C2601/08 , C07C2601/14 , C07D295/13
摘要： An object of the present invention is to provide a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof and to provide a pharmaceutical agent which contains said compound as an active ingredient and has a highly safe neurotrophic factor-like activity or an alleviating action for side effect induced by administration of anti-cancer agents. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof which is the compound of the present invention is specifically represented by the formula (1): (In the formula, Y is -O-, -NR- or -S-, R is hydrogen atom, alkyl group, dialkylaminoalkyl group or the like and W is a substituent such as dialkylaminoalkyl group) and has a quite high usefulness as a pharmaceutical agent such as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression, etc., a treating or repairing agent for spinal cord injury or an alleviating agent for side effect induced by administration of anti-cancer agents.
-
公开(公告)号：EP2695613A1
公开(公告)日：2014-02-12
申请号：EP12742101.4
申请日：2012-01-30
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , OKADA, Tomoyuki , MATSUMOTO, Tomonori , SAWADA, Kazuyoshi
IPC分类号： A61K31/201 , A61P29/00
CPC分类号： A61K31/23 , A61K31/231
摘要： An object of the present invention is to provide an analgesic effective in a prophylactic or a therapy for various pain diseases. The present invention is to provide an analgesic containing an ester of C 10 fatty acid as an active ingredient. The analgesic of the present invention containing the compound as an active ingredient is highly useful as a prophylactic or therapeutic agent for various pain diseases such as the pain caused by osteoarthritis (e.g., knee osteoarthritis and hip osteoarthritis) or by demyelinating diseases such as multiple sclerosis or Guillain-Bareé syndrome.
摘要翻译： 本发明的目的是提供对各种疼痛疾病的预防或治疗有效的止痛剂。 本发明提供含有C10脂肪酸酯作为有效成分的镇痛剂。 含有该化合物作为有效成分的本发明的镇痛剂作为各种疼痛疾病的预防或治疗剂非常有用，所述疼痛疾病诸如由骨关节炎（例如膝骨关节炎和髋关节骨关节炎）引起的疼痛或通过脱髓鞘疾病如多发性硬化症 或格林 - 巴利综合征。
-
公开(公告)号：EP2842942B1
公开(公告)日：2016-12-07
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.
-
公开(公告)号：EP2842942A1
公开(公告)日：2015-03-04
申请号：EP13781244.2
申请日：2013-04-26
发明人： IINUMA, Munekazu , FURUKAWA, Shoei , NAIKI, Mitsuru , MATSUMOTO, Tomonori , HIGASHIURA, Kunihiko
IPC分类号： C07D207/16 , A61K9/70 , A61K31/40 , A61K31/401 , A61K31/426 , A61K31/445 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K31/55 , A61K31/551 , A61K47/40 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/22
CPC分类号： C07D295/185 , C07D207/08 , C07D207/16 , C07D211/16 , C07D211/18 , C07D211/26 , C07D211/30 , C07D211/44 , C07D211/46 , C07D211/48 , C07D211/58 , C07D211/62 , C07D211/74 , C07D213/74 , C07D239/42 , C07D243/08 , C07D277/04 , C07D295/18
摘要： The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I):
wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.摘要翻译： 本发明涉及新型反式-2-癸烯酸衍生物或其药学上可接受的盐以及含有该化合物作为活性成分的药剂。 作为本发明化合物的反式-2-癸烯酸衍生物或其药学上可接受的盐具体由通式（I）表示：其中X是取代基，例如1-吡咯烷基，3-噻唑基 或哌啶子基，该化合物作为抗癌剂的给药诱导的周围神经障碍的预防或治疗剂，神经变性疾病的预防或治疗剂或痴呆等精神疾病的药剂非常有用 ，阿尔茨海默氏病，帕金森病，糖尿病性神经病，抑郁症，青光眼或自闭症谱，脊髓损伤的治疗剂或修复剂，针对各种疼痛疾病的镇痛剂等。
-
公开(公告)号：EP3421989A1
公开(公告)日：2019-01-02
申请号：EP17756664.3
申请日：2017-02-24
摘要： The object of the present invention is to provide a test method using a novel administration method of an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract.
It has been demonstrated that by sustainedly administering an extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract by using a continuous administration device according to the present invention, a comparable effect is exerted at a very low dose compared with conventional administration methods such as oral administration. Therefore, the present invention can provide a test method using animals requiring less burden on a researcher, a treatment of patient at a low dose, and the like.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.016 秒)
